One-year outcomes in children with eosinophilic esophagitis

Abstract

Background and aims

Despite rising incidence of eosinophilic esophagitis (EoE), data on the follow-up and treatment outcomes in pediatric patients are scarce. Therefore, the aim of this study was to present data on the treatment outcomes in children diagnosed with EoE who were treated in a tertiary medical center.

Patients and methods

A retrospective study involving patients younger than 18 years who were diagnosed with EoE in our center between January 2011 and June 2017.

Results

Thirty-two patients met inclusion criteria and were followed up for a mean of 3 years (range 0.5–6.8). Six months after the diagnosis, 28 (87.5%) children were still followed up; 21 (75%) were in clinical remission, including 10 (36%) who were in histological remission. After 12 months, 27 patients were still followed up; 21 (78%) achieved clinical remission, including 10 (37%) with histological remission. During follow-up, three patients developed gastroesophageal reflux disease (GERD). There was no difference in body mass index (BMI) Z score between baseline and 12 months follow-up (median − 0.3 vs − 0.3 SD, p = 0.862).

Conclusions

Absence of symptoms does not indicate mucosal healing; therefore, patients should be followed up endoscopically. Additionally, despite restricted diet, nutritional status remains unaffected. Finally, patients with EoE can develop significant GERD even years after the EoE diagnosis.