Clinical Snippets

The opportunistic skin bacterium Propionibacterium acnes has been linked to acne vulgaris, a condition that affects more than 40 million people in the United States and has mostly inadequate or intolerable therapies. Following prior studies indicating that the P. acnes secretory virulence factor Christie-Atkins-Munch-Peterson (CAMP) factor is the main source of inflammation in acne vulgaris, Wang and colleagues demonstrated that a vaccination strategy targeting CAMP factor reduced the growth of P. acnes, diminished associated erythema, and limited production of proinflammatory cytokines in mice.