The effect of levamisole in the treatment of recalcitrant recurrent erythema multiforme major: An observational study

Erythema multiforme major (EMM) is an immune-mediated mucocutaneous eruption characterized by distinctive cutaneous target lesions with variable mucosal involvement. EMM is usually triggered by herpes simplex virus (HSV), Mycoplasma pneumoniae (M. pneumoniae), or other infections. Reactivation or reinfection of HSV accounts for more than 70% of cases of recurrent EMM. Although the majority of patients have a benign clinical course, more than 30% of patients suffer from frequent recurrences of EMM over years, leading to substantial morbidity [1,2].