Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice

Humans have witnessed huge exploration and extensive utilization of heavy metal in the past few centuries. As a result, tremendous amount of heavy metal has entered the environment, in soil, water, and air, and inevitably into human bodies. In terms of millions of years of human evolution, elevation of the levels of heavy metal in the body is a quite recent event [1]. Increased body levels of heavy metal can cause many harmful effects [2]. Despite some heavy metals are essential for human body, toxic levels can cause inflammation and oxidative stress [3–6].