Systematic review of placebo responses in randomized clinical trials of systemic therapy for atopic dermatitis

Introduction: Atopic dermatitis (AD) is associated with a variable disease severity and symptom burden and intermittent periods of disease remittance, all of which may contribute to increased placebo responses in randomized clinical trials (RCT). However, little is known about the rates and predictors of placebo responses in RCT of systemic therapy in AD.