Sodium thiosulfate injection dissolves calcium hydroxylapatite particles: An animal study

Background and objective: Treatment of certain dermal filler–related serious AEs (e.g., vascular occlusion, granulomatous reactions) may include removal of the injected material. Hyaluronidase can be used to degrade hyaluronic acid fillers; however, no agents have yet been shown to fully dissolve calcium hydroxylapatite (CaHA; Merz North America) filler after placement. Sodium thiosulfate (STS) has been shown to decrease calcium mineral deposits associated with calciphylaxis, calcific uremic arteriolopathy, and kidney stones.