P-189Retinoic acid-induced 2 (RAI2) is a potential tumor suppressor and RAI2 promoter methylation is a poor prognostic marker in colorectal cancer

Introduction: Retinoic acid (RA) plays an important role in development, adult hematopoiesis and cell differentiation. Retinoic acid induced 2 (RAI2) was originally discovered to be induced by retinoic acid in embryonal carcinoma cells. Low retinoic acid induced 2 (RAI2) expression was found in breast cancer as an independent poor prognostic factor, promoting early hematogenous dissemination of human breast cancer cells to bone marrow. The expression of Retinoic acid induced 2 (RAI2) was found reduced in colorectal cancer (CRC) by searching The Cancer Genome Atlas (TCGA) database. The regulation and function of RAI2 in human cancer remain unclear. In this study, we focused on the epigenetic regulation and function of RAI2 in colorectal cancer (CRC).