P-257Improvement of metastatic colorectal cancer patient survival: Single institution experience

Introduction: The outcome of patients with metastatic colorectal cancer (mCRC) has significantly improved over the last two decades, reaching a median overall survival (mOS) of around 30 months, more than double that 20 years ago. Both surgery and a more aggressive systemic approach may have contributed to this result. The aim of this study is to describe the evolution of survival of mCRC patients followed at a single institution over the past 17 years, investigating the possible influence of tumour characteristics, as well as the changes in treatment practice through the years.