Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio)propanoate suppresses melanogenesis through ERK signaling pathway mediated MITF proteasomal degradation

Melanin is synthesized for protecting the skin against extensive environmental stimuli a deficiency of epidermal melanin induces the increase of skin aging as wrinkle and hyperpigmentation such as hypermelanotic skin disorders such as melisma, ephelides, and solar lentigines [1,2]. Melanin production is increased in skin melanocytes following the secretion of the hormones in UV-stimulated keratinocytes [3]. During production of melanins, melanogenic enzymes such as tyrosinase (TYR), tyrosinase related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) was synthesized [1,4].