Activated mTORC1 signaling: The common driving force of type 2 diabetes and hidradenitis suppurativa

To the Editor: The results of the recent meta-analysis by Bui et al have confirmed that hidradenitis suppurativa (HS) is significantly associated with an increased prevalence of type 2 diabetes mellitus (T2DM).1 According to the authors, this association could be due to the fact that HS patients tend to be more obese.1 In this regard, we think that altered mechanistic target of rapamycin complex 1 (mTORC1) signaling might contribute and explain the connection between HS and T2DM. mTOR is the core constituent of the phosphatidylinositol 3-kinase–related kinase protein family that forms at least 2 multiprotein complexes known as mTORC1 and mTORC2.