Characterization of centriole duplication in human epidermis, Bowen’s disease, and squamous cell carcinoma

The centrosome is the microtubule-organizing center of animal cells. Each cell has one centrosome, comprising a pair of centrioles and the surrounding pericentriolar material (PCM) [1]. Centrosomes are involved in spindle pole assembly, cell polarity, cell migration, and maintenance of cellular stemness [2–4]. Numerical and structural centrosome abnormalities have been observed in many human carcinomas including pre-invasive carcinomas. It remains unclear whether centrosome abnormalities cause, or are a result of, tumorigenesis [5].