Autoinflammatory keratinization diseases: an emerging concept encompassing various inflammatory keratinization disorders of the skin

Among the myriad diseases affecting the skin are a subset of disorders whose main pathobiology is inflammation, predominantly in the epidermis and the superficial dermis, that leads to hyperkeratosis, manifesting clinically as thickened scaly skin. These are designated as "inflammatory keratinization disorders". The category includes many conditions that are poorly defined, although some, including psoriasis and lichen planus, are better categorized.