Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A > C polymorphism with Vitiligo susceptibility in Gujarat

Vitiligo is one of the most common cosmetic disfigurement disorders caused due to loss of functional melanocytes from the epidermis [1]. The disease can affect individuals of any race or sex and manifests before the age of 20 years in approximately half of the patients [2]. Worldwide prevalence of vitiligo is about 0.06–2.28% of the population [3]. The etiology of vitiligo is complex, however, certain genetic predisposition factors and a number of potential precipitating events such as oxidative stress, autoimmunity, neurological factors etc.