A lamellar body mimetic system for the treatment of oxazolone-induced atopic dermatitis in hairless mice

Atopic dermatitis is a common skin disease characterized by inflammatory, pruritic eczema. It is a multifactorial disease which involves a complex interplay of environmental and genetic factors. Atopic dermatitis shows a Th2 cell-dominant inflammatory infiltrate, elevated serum IgE levels and impaired epidermal barrier function [1], indicated by an increased transepidermal water loss (TEWL) [2] and decreased water-holding capacity [3].