Sweat Mechanisms and Dysfunctions in Atopic Dermatitis

Atopic dermatitis (AD) is a chronic inflammatory dermatosis that involves a complex interplay between genetic, immunologic and environmental factors [1]. Barrier abnormalities play an important role in the pathogenesis of AD, as mutations in the gene for the structural protein filaggrin (FLG) result in increased epidermal permeability, decreased SC hydration and increased pH [2,3]. SC pH provides an acidic environment for optimal antimicrobial enzyme activity and surface microbiome diversity [4].