A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity

Skin primarily consists of three different cell types: keratinocytes, fibroblasts, and melanocytes. Melanocytes are specialized cells that synthesize pigment, which is also known as melanin. Melanin is a heterogeneous biopolymer that is produced in melanosomes, which are organelles that synthesize, store, and transport melanin through a series of enzymatic reactions known as melanogenesis. Melanogenesis involves the catalysis of tyrosine by TYR-family proteins, including TYR and TYR-related protein 1/2 (TRP-1/2) [1,2].