Src kinase mediates UV-induced TRPV1 trafficking into cell membrane in HaCaT keratinocytes

Abstract

The skin is constantly exposed to harmful external stimuli such as pathogen, particulate matter, and sunlight. Solar radiation consists of various types of rays, among which ultraviolet (UV), visible light, and infrared can reach the earth and thereby affect human skin (1). Especially, UV has several detrimental effects on the skin including cutaneous cancer, inflammation, and photoaging (2). When skin cells are exposed to UV, it causes nuclear factor kappa B (NF-kB) signaling pathway leading to the increases of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-8 (3).

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