Polydeoxyribonucleotide (PDRN) Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers.

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Polydeoxyribonucleotide (PDRN) Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers.

Arch Plast Surg. 2017 Oct 26;:

Authors: Kim S, Kim JH, Choi J, Jeong W, Kwon S

Abstract
Background: Polydeoxyribonucleotide (PDRN) is known to have anti-inflammatory and angiogenetic effects and to accelerate wound healing. The aim of this study was to investigate whether PDRN could improve the peripheral tissue oxygenation and angiogenesis in diabetic foot ulcer patient.
Methods: This was a prospective randomized controlled clinical trial. Twenty patients with non-healing diabetic foot ulcer were randomly distributed into control group (n=10) and PDRN group (n=10). Initial surgical debridement and secondary surgical procedures such as split thickness skin graft, primary closure or local flap were performed. Between initial surgical debridement and secondary surgical procedures, 0.9% normal saline (3 mL) or PDRN was injected for 2 weeks by intramuscular (1 ampule, 3 mL, 5.625 mg, 5 days a week) and perilesional route (1 ampule, 3 mL, 5.625 mg, 2 days a week). Transcutaneous oxygen tension (TcPO2) was evaluated by Periflux System 5000 with TcPO2/CO2 unit 5040 before injection, and on day 1, day 3, day 7, day 14, and day 28. With debrided specimens, pathologic review (H&E stain) and vessel density (average number of vessel/visual field) were reviewed by a pathologist.
Results: Compared with the control group, the PDRN treated group had improvement of peripheral tissue oxygenation on day 7 (P<0.01), day 14 (P<0.001), and day 28 (P<0.001). The pathologic review of the PDRN group shows an angiogenesis effect and improvement of the inflammatory state compared with the control group. Between the control group and the PDRN group, there was no statistical difference on vessel density (p=0.094). Complete healing was achieved in every patient.
Conclusions: In this study, PDRN improved peripheral tissue oxygenation. Moreover, PDRN is thought to be effective in improving inflammation and angiogenesis of diabetic foot ulcers.

PMID: 29076318 [PubMed - as supplied by publisher]