B Vitamin Complex and Chemotherapy-Induced Peripheral Neuropathy

Abstract

Purpose of Review

The purpose of this mini review is to evaluate the literature on B vitamins and chemotherapy-induced peripheral neuropathy.

Recent Findings

One hundred and five journal articles were evaluated and nine manuscripts were included. There was one in vitro, one was an animal and seven were human studies. The in vitro study was a safety study on vitamin B₆ and oxaliplatin which was not directly related to CIPN. The animal study evaluated vitamin B₃ on paclitaxel administration with positive results. The human studies varied using a vitamin B complex, vitamin B₁₂ only and vitamin B₆.

Summary

Chemotherapy-induced peripheral neuropathy (CIPN) continues to plague patients and the medical fraternity. Currently, there are still no conclusive protective or treatment options. B vitamins have been found to play a role in CIPN prevention, but further studies are required to ascertain possible protection and treatment options.