The Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo

xlomafota13 shared this article with you from Inoreader The Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo Via ear nose throat Ear Nose Throat J. 2021 Apr 18:1455613211008561. doi: 10.1177/01455613211008561. Online ahead of print. ABSTRACT OBJECTIVE: This study aimed to evaluate the association between serum vitamin D levels and benign paroxysmal positional vertigo (BPPV). PARTICIPANTS AND METHODS: This prospective study consisted of 137 participants. There were 69 participants in the BPPV group compared with 68 healthy participants. Blood samples from both groups were collected from all parti cipants to assess serum vitamin D levels. RESULTS: No significant difference in demographic data between BPPV and control groups. The results showed that the mean serum vitamin D levels in the BPPV group was lower than that of the control group (P value = .001). Among BPPV participants, there was no statistically significant difference between mean serum vitamin D levels of participants with recurrent BPPV, and that of newly diagnosed BPPV participants (P value = .313). CONCLUSION: A statistically significant association between lower mean serum vitamin D levels in the BPPV group compared with that of the control group. Therefore, low serum vitamin D levels may be one of the risk factors for BPPV. PMID:33866868 | DOI:10.1177/01455613211008561 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Relative Humidity Affects Acute Otitis Media Visits of Preschool Children to the Emergency Department

xlomafota13 shared this article with you from Inoreader Relative Humidity Affects Acute Otitis Media Visits of Preschool Children to the Emergency Department Via ear nose throat Ear Nose Throat J. 2021 Apr 18:1455613211009151. doi: 10.1177/01455613211009151. Online ahead of print. ABSTRACT OBJECTIVE: The associations between climate variables and diseases such as respiratory infections, influenza, pediatric seizure, and gastroenteritis have been long appreciated. Infection is the main reason for acute otitis media (AOM) incidence. However, few previous studies explored the correlation between climatic parameters and AOM infections. The most importan t meteorological factors, temperature, relative humidity, and fine particulate matter (PM2.5), were included in this study. We studied the relationship between these meteorological factors and the AOM visits. MATERIALS AND METHODS: It was a retrospective cross-sectional study. A linear correlation and a linear regression model were used to explore the AOM visits and meteorological factors. RESULTS: A total of 7075 emergency department visits for AOM were identified. Relative humidity was found an independent risk factor for the AOM visits in preschool children (regression coefficient = -10.841<0, P = .039 < .05), but not in infants and school-age children. Average temperature and PM2.5 were not correlated with AOM visits. CONCLUSION: Humidity may have a significant inverse impact on the incidence of AOM in preschool-age children. PMID:33866869 | DOI:10.1177/01455613211009151 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Interpersonal functioning and body image dissatisfaction in patients referred for NHS aesthetic surgery: A mediating role between emotion regulation and perfectionism?

xlomafota13 shared this article with you from Inoreader Interpersonal functioning and body image dissatisfaction in patients referred for NHS aesthetic surgery: A mediating role between emotion regulation and perfectionism? Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Jan 31:S1748-6815(21)00046-2. doi: 10.1016/j.bjps.2021.01.003. Online ahead of print. ABSTRACT BACKGROUND: Few studies have explored psychological factors associated with body image dissatisfaction in individuals seeking aesthetic surgery on the NHS. In NHS Scotland, The Adult Exceptional Aesthetic Referral Protocol (AEARP) states that individuals are only eligible for consideration for surgery where there is significant psychological distress and physical criteria associated with perceived problem of appearance. The AEARP necessitates that individuals seeking aesthetic surgery on the NHS must have a psychological assessment. It is therefore crucial to identify psychological factors associated with body image dissatisfaction that may highlight contraindications for surgery or are amenable to psychological intervention. METHOD: A total of 311 consecutive patients seeking aesthetic surgery who we re referred for psychological assessment under the AEARP completed a series of psychometric measures as part of routine clinical practice. Multiple mediation analyses using bootstrapped method was used to explore the relationship between interpersonal functioning, emotion regulation, perfectionism, and body image dissatisfaction. RESULTS: Multiple mediation analysis indicated that emotion regulation partially mediates the relationship between interpersonal functioning and body image dissatisfaction in this clinical population. CONCLUSION: This study indicates that interpersonal functioning and emotion regulation significantly relate to body image dissatisfaction in this patient group. Psychological assessment of patient suitability for aesthetic surgery should include assessment of interpersonal functioning and emotion regulation which may be amenable to psychological intervention and be of significant benefit to patients either pre- or post-operatively or instead of sur gery. PMID:33867281 | DOI:10.1016/j.bjps.2021.01.003 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Lymph-interpositional-flap transfer (LIFT) based on lymph-axiality concept: Simultaneous soft tissue and lymphatic reconstruction without lymph node transfer or lymphatic anastomosis

xlomafota13 shared this article with you from Inoreader Lymph-interpositional-flap transfer (LIFT) based on lymph-axiality concept: Simultaneous soft tissue and lymphatic reconstruction without lymph node transfer or lymphatic anastomosis Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Mar 25:S1748-6815(21)00104-2. doi: 10.1016/j.bjps.2021.03.014. Online ahead of print. ABSTRACT BACKGROUND: Lymphatic system is important to maintain homeostasis. Lymph-axiality concept has been reported, which suggests possibility of lymphatic reconstruction using flap transfer without lymph node or supermicrosurgical lymphatic anastomosis. METHODS: Medical charts of 122 free flap reconstruction cases, either with conventional flap transfer (control) or lymph-interpositional-flap transfer (LIFT), for extremity soft tissue defects including lymphatic pathways were reviewed. Lymph vessels' stumps in a flap were placed as close to those in a recipient site as possible under indocyanine green (ICG) lymphography navigation in LIFT group. LIFT group was subdivided into LIFT(+) and LIFT(-) groups; lymph vessels' stumps could be approximated within 2 cm in LIFT(+) group, whereas those could not be in L IFT(-) group. Lymph flow restoration (LFR) and lymphedema development (LED) rates were compared between the groups on postoperative 6 months. RESULTS: No flap included lymph node. LFR was observed in 50 cases and LED in 72 cases. LFR rate in LIFT group (n = 75) was significantly higher than that in control group (n = 47) (57.3% vs. 14.9%; P < 0.001). LED rate in LIFT group was significantly lower than that in control group (20.0% vs. 48.9%; P < 0.001). Sub-group analysis showed significantly higher LFR and lower LED rates in LIFT(+) group (n = 44) than those in LIFT(-) group (n = 31; 88.6% vs. 12.9%; P < 0.001, 4.5% vs. 41.9%; P < 0.001). CONCLUSIONS: LIFT allows simultaneous soft tissue and lymphatic reconstruction without lymph node transfer or lymphatic anastomosis, which prevents development of secondary lymphedema. PMID:33867280 | DOI:10.1016/j.bjps.2021.03.014 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Traumatic rupture of a cystic parathyroid adenoma resulting in malignant hypercalcaemia

xlomafota13 shared this article with you from Inoreader Traumatic rupture of a cystic parathyroid adenoma resulting in malignant hypercalcaemia Via oto-rhino-laryngologie Eur Ann Otorhinolaryngol Head Neck Dis. 2021 Apr 15:S1879-7296(21)00063-6. doi: 10.1016/j.anorl.2021.04.001. Online ahead of print. NO ABSTRACT PMID:33867248 | DOI:10.1016/j.anorl.2021.04.001 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps (CRSwNP) in Brazil

xlomafota13 shared this article with you from Inoreader Guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps (CRSwNP) in Brazil Via Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial Braz J Otorhinolaryngol. 2021 Apr 3:S1808-8694(21)00062-8. doi: 10.1016/j.bjorl.2021.03.003. Online ahead of print. ABSTRACT INTRODUCTION: Severe uncontrolled chronic rhinosinusitis with nasal polyps has a negative impact on an individual's quality of life. Therefore, new biologics have emerged for use in specific phenotypes of chronic rhinosinusitis, changing the paradigms of its treatment. OBJECTIVE: To review the current status of biologic treatment indications in chronic rhinosinusitis. METHODS: The Brazilian Academy of Rhinology brought together different specialists to suggest a course of action, considering its particularities and aspects related to the national reality. RESULTS: Of particular interest for decision making will be the identification of subgroups of patients refractory to pre-existing treatment options and the construction of a strategy that improves their quality of life, with the best cost-bene fit ratio. CONCLUSION: The use of biologics is a valid option for treatment in more severe cases. This strategy must be better understood and improved in the future, with more studies and greater clinical experience. PMID:33867274 | DOI:10.1016/j.bjorl.2021.03.003 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A case of cavernous hemangioma of the infratemporal fossa causing recurrent secretory otitis media

xlomafota13 shared this article with you from Inoreader A case of cavernous hemangioma of the infratemporal fossa causing recurrent secretory otitis media Via Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial Braz J Otorhinolaryngol. 2021 Mar 26:S1808-8694(21)00060-4. doi: 10.1016/j.bjorl.2021.03.001. Online ahead of print. ABSTRACT Secretory otitis media causes aural fullness and hearing loss secondary to Eustachian tube obstruction or incomplete resolution of acute otitis media. Every patient with unilateral middle ear effusion should undergo nasopharyngoscopy to assess the nasopharyngeal space. Expansive lesions at the level of pterygopalatine fossa may cause Eustachian tube compression with tube dysfunction with clinical findings of recurrent unilateral secretory otitis media. In this paper, a 55 years old man presented with a history of hearing loss and fullness in the left ear. Brain MRI scan showed the presence on the left side of a solid mass in the infratemporal masticatory space and the patient underwent endoscopic transnasal resection of the lesion. At 6 months follow-up there was no evidence of disease recurrency. In our opinion , it is important to add an imaging tool to the diagnostic algorithm in all those cases of secretory otitis media lasting more than 3 months that present a negative nasopharyngoscopy evaluation. PMID:33867275 | DOI:10.1016/j.bjorl.2021.03.001 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hepatic Macrophage activation and the LPS pathway in patients with different degrees of severity and histopathological patterns of drug induced liver injury

xlomafota13 shared this article with you from Inoreader Hepatic Macrophage activation and the LPS pathway in patients with different degrees of severity and histopathological patterns of drug induced liver injury Via Cellular and Molecular Biology Histol Histopathol. 2021 Apr 15:18340. doi: 10.14670/HH-18-340. Online ahead of print. ABSTRACT BACKGROUND: Inflammatory activation of hepatic macrophages plays a primary role in drug-induced liver injury (DILI). However, the exact mechanism underlying DILI remains unclear. METHODS: A total of 328 DILI patients and 80 healthy individuals were prospectively enrolled in this study. The DILI patients were categorized into subgroups based on either disease severity or histopathological patterns. Plasma soluble CD163 (sCD163) and hepatic CD163 were examined to determine hepatic macrophage activation, and CD8, CD20, and MUM-1 were assessed to determine cellular immunity using immunohistochemistry. The lipopolysaccharide (LPS) pathway proteins [e.g. LPS, soluble CD14 (sCD14), and LPS-binding protein (LBP)] were measured using enzyme-linked immunosorbent assay. RESULTS: Plasma sCD163 levels were nine-fold higher in DILI patients th an in healthy controls at the baseline, but significantly decreased at the 4-week follow-up visit after treatment. The numbers of hepatic macrophages, B cells, and plasma cells were significantly higher in the liver tissues from DILI patients than those from healthy controls. Furthermore, the baseline levels of LPS pathway proteins in the DILI patients were significantly higher than those in the controls. Notably, these proteins significantly decreased at the 4-week follow-up visit but remained significantly higher than the levels for the controls. CONCLUSIONS: Hepatic inflammation in DILI involves the activation of hepatic macrophages and cellular immunity, in which the LPS pathway likely plays a role, at least in part. As such, this study has improved our understanding of the pathological mechanisms for DILI and may facilitate the development of better treatments for patients with DILI. PMID:33870482 | DOI:10.14670/HH-18-340 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Measuring stiffness of normal medial collateral ligament in healthy volunteers via shear wave elastography

xlomafota13 shared this article with you from Inoreader Measuring stiffness of normal medial collateral ligament in healthy volunteers via shear wave elastography Via radiol anat Surg Radiol Anat. 2021 Apr 19. doi: 10.1007/s00276-021-02749-y. Online ahead of print. ABSTRACT PURPOSE: We aim to determine a reference data set for normal medial collateral ligament (MCL) stiffness values using shear wave elastography (SWE). METHODS: Quantitative stiffness of the MCL was measured at three levels: the proximal (MCL area from the level of the medial meniscus to the level of the femoral attachment), the middle (MCL area at the level of the medial menisc us), and the distal (MCL area from the level of the medial meniscus to the level of the tibial attachment) segments of the MCL at a knee position of 0°. RESULTS: A total of 60 MCL of 30 healthy volunteers (15 female, 15 male) were examined. The mean stiffness values of the proximal, middle, and distal MCL for observer 1 were 32.25 ± 6.44, 34.25 ± 6.84, and 35.47 ± 6.98, respectively. The mean stiffness values of the proximal, middle, and distal MCL for observer 2 were 33.56 ± 6.76, 35.44 ± 6.91, and 36.32 ± 7.04, respectively. CONCLUSION: SWE has a strong potential to be a method of choice for evaluating MCL stiffness. Our study participants were healthy volunteers and the data can be used as reference data for future studies. PMID:33871710 | DOI:10.1007/s00276-021-02749-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Severe Form of Bacterial Meningitis After Spine Surgery: A Case Report and Review of the Literature

xlomafota13 shared this article with you from Inoreader Severe Form of Bacterial Meningitis After Spine Surgery: A Case Report and Review of the Literature Via leak of cerebrospinal fluid Cureus. 2021 Mar 14;13(3):e13877. doi: 10.7759/cureus.13877. ABSTRACT Meningitis after spine surgery is a rare complication. In this report, we aim to discuss the case of a male patient who developed this rare condition after undergoing cervical spine surgery with devastating outcomes. We also engage in a review of the relevant literature. A 17-year-old boy presented with post-traumatic cervical kyphotic deformity with signs of cord compression. He was operated in three stages, all conducted in a single sitting. There was an incidental cerebrospinal fluid (CSF) leak, which was primarily repaired. On the fourth postoperative day, the patient developed altered sensorium and seizures. Evaluations for clinical signs of meningitis such as neck rigidity and Kernig's sign were inconclusive. CSF analysis confirmed the diagnosis of meningitis. Thereafter, the patient developed hydrocephalus and intractable infection, for which multiple procedures were done. Finally, we succeeded in controlling the infection, but the patient developed a neurological deficit, which did not resolve even after 2.5 years of follow-up. The clinical signs and symptoms of meningitis after cervical spine surgery are not very clear or suggestive. A strong index of suspicion should be maintained for the early detection of this condition to prevent devastating complications that result from it. PMID:33868841 | PMC:PMC80432 17 | DOI:10.7759/cureus.13877 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Patterns of Care and Outcomes of Primary Adenoid Cystic Carcinoma of the Trachea

xlomafota13 shared this article with you from Inoreader Patterns of Care and Outcomes of Primary Adenoid Cystic Carcinoma of the Trachea Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Apr 19:34894211008101. doi: 10.1177/00034894211008101. Online ahead of print. ABSTRACT OBJECTIVE: Primary tracheal malignancies are relatively rare cancers, representing 0.1% to 0.4% of all malignancies. Adenoid cystic carcinoma (ACC) is the second most common histology of primary tracheal malignancy, after squamous cell carcinoma. This study aims to analyze demographic characteristics and potential influencing factors on survival of tracheal A CC (TACC). METHODS: This was a retrospective cohort study utilizing the National Cancer Database (NCDB). The NCDB was queried for all cases of TACC diagnosed from 2004 to 2016 (n = 394). Kaplan-Meier (KM) and Cox proportional-hazards models were used to determine clinicopathological and treatment factors associated with survival outcomes. RESULTS: Median age of diagnosis was 56 (IQR: 44.75-66.00). Females were affected slightly more than males (53.8% vs 46.2%). The most prevalent tumor diameter range was 20 to 39 mm (34.8%) followed by greater than 40 mm in diameter (17.8%). Median overall survival (OS) was 9.72 years with a 5- and 10-year OS of 70% and 47.5%, respectively. Localized disease was not associated with a survival benefit over invasive disease (P = .388). The most common intervention was surgery combined with radiation therapy (RT) at 46.2%, followed by surgery alone (16.8%), and standalone RT (8.9%). When adjusting for confounders, surgical resection was independently associated with improved OS (HR 0.461, 95% CI 0.225-0.946). Tumor size greater than 40 mm was independently associated with worse OS (HR 2.808; 95% CI 1.096-7.194). CONCLUSION: Our data suggests that surgical resection, possibly in conjunction with radiation therapy, is associated with improved survival, and tumor larger than 40 mm are associated with worse survival. PMID:33870720 | DOI:10.1177/00034894211008101 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.