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Παρασκευή 30 Οκτωβρίου 2020

Immediate Intraoperative Repair of the Recurrent Laryngeal Nerve in Thyroid Surgery

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Objectives

Recurrent laryngeal nerve (RLN) injury is a recognized risk during thyroid and parathyroid surgery and can result in significant morbidity. The aim of this review paper is to consider the optimal approach to the immediate intraoperative repair of the RLN during thyroid surgery.

Methods

A PubMed literature search was performed from inception to June 2020 using the following search strategy: immediate repair or repair recurrent laryngeal nerve, repair or reinnervation recurrent laryngeal nerve and immediate neurorraphy or neurorraphy recurrent laryngeal nerve.

Results

Methods of immediate intraoperative repair of the RLN include direct end‐to‐end anastomosis, free nerve graft anastomosis, ansa cervicalis to RLN anastomosis, vagus to RLN anastomosis, and primary interposition graft. Techniques of nerve repair include micro‐suturing, use of fibrin glue, and nerve grafting. Direct micro‐suture is preferable when the defect can be repaired without tension. Fibrin glue has also been proposed for nerve repair but has been criticized for its toxicity, excessive slow reabsorption, and the risk of inflammatory reaction in the peripheral tissues. When the proximal stump of the RLN cannot be used, grafting could be done using transverse cervical nerve, supraclavicular nerve, vagus nerve, or ansa cervicalis.

Conclusions

Current evidence is low‐level; however, it suggests that when the RLN has been severed, avulsed, or sacrificed during thyroid surgery it should be repaired intraoperatively. The immediate repair has on balance more advantages than disadvantages and should be considered whenever possible. This should enable the maintenance of vocal cord tone, better and prompter voice recovery and avoidance of aspiration. Laryngoscope, 2020

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Evaluation of adjuvant vaginal vault brachytherapy in early stage cervical cancer patients

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Publication date: Available online 29 October 2020

Source: Cancer/Radiothérapie

Author(s): E. Bronsart, C. Petit, S. Gouy, S. Bockel, S. Espenel, T. Kumar, I. Fumagalli, A. Maulard, R. El Ayachy, C. Genestie, A. Leary, P. Pautier, P. Morice, C. Haie-Meder, C. Chargari

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Vertebral compression fracture during stereotactic body radiotherapy for spinal metastasis: A rare case of tracking failure

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Publication date: Available online 29 October 2020

Source: Cancer/Radiothérapie

Author(s): S. Godin, A.-D. Durham, L. Schiappacasse, E.-M. Ozsahin, F. Vilotte

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Postoperative radiotherapy after flap reconstructive surgery in patients with head and neck cancer: A retrospective monocentric study with flap delineation to assess toxicity and relapse

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Publication date: Available online 29 October 2020

Source: Cancer/Radiothérapie

Author(s): G. Michaël, J. Le Guevelou, N. Jacksic, J. Lequesne, V. Bastit, B. Géry, C. Jeanne, A. Batalla, J. Lacroix, E. Kammerer, A. Lasne-Cardon, J. Thariat

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AuDacity 2020 Highlight: Using the COM-B Model to Understand Hearing Aid Accessibility, Affordability

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Via Audiology

Cost and inaccessibility are often thought to be the primary factors why people with hearing loss are not getting over-the-counter hearing aids. But according to Brent Edwards, PhD, Director at the National Acoustic Laboratories in Australia, it may not be enough to only think about accessibility and affordability.

"[If] you Google affordable hearing aids or you go to Amazon and search for hearing aids, you'll find all kinds of hearing aids that are fairly affordable that can be delivered to you tomorrow," Edwards noted. There are many other factors that may explain why OTC or direct-to-consumer hearing aids are not fully adopted, he said.

Edwards proposed a different perspective during his featured presentation at AuDacity 2020, a conference organized by the Academy of Doctors of Audiology, together with the Independent Audiologists Australia (IAA) and Independent Audiologists New Zealand (IANZ). His presentation focused on using the COM-B model to identify reasons for the behavior of non-adopters of hearing aids.

COM-B model on hearing aid adoption

The COM-B model is a framework that helps health care professionals understand why people do what they do. It examines people's Capability, Opportunity, and Motivation, all of which shape their Behavior. Edwards used this tool to illustrate that OTC hearing aid adoption is not just a matter of cost and accessibility.

First, he zoomed in on a population segment that is relevant to the issue. Collectively labeled the HD-HL segment, this is composed of people who have audiometric hearing loss (as measured by an audiogram) and at the same time affirm that they experience hearing difficulty. Edwards said that about half of this segment do not own hearing aids, and this half was the focus of his COM-B analysis.

According to Edwards, the rejection of hearing aids involves "Capability" factors, such as a person's agility limitations and lack of skills to us e OTC hearing aids. This tied with recent MarkeTrak data showing that half of the people with hearing loss were uncomfortable with tasks associated with OTC devices, like assessing their own hearing loss, selecting their device solution, fitting it, and maintaining it.

Meanwhile, "Opportunity" factors include social stigma, lack of support, high cost, and inaccessibility. Finally, "Motivation" factors may include stigma, the perception that one's hearing loss is not bad enough, and the perception that getting hearing aids is not worth the effort.

"So accessibility and affordability are just two of many, many factors that are necessary to get people in this segment to choose hearing aids," Edwards emphasized.

Improving hearing aid adoption requires changes that address these COM factors. For instance, to address Capability barriers, Edwards suggested that OTC devices should be popularized in a way that people can select and fit the device themselves, and manage it e asily with an accompanying app.

Opportunity barriers can be overcome not only by making hearing aids accessible and affordable, but also by making them socially acceptable, with available support from others. And to steer people's Motivation, hearing aid stigma has to be minimized, potential users have to believe in self-treatment, and they have to be surrounded by a supportive environment.

Hearing aids for a focused population segment

Early in his presentation, Edwards explained that not all people who have auditory dysfunction may be considered for OTC hearing aid use, so some statistics on hearing aid adoption may have been overstated. He cited various industry reports stating that majority of people with hearing loss in the US are not getting the hearing aids that could help them.

"[I]f these are true, we're probably doing not the best job that we could be in treating the public with hearing loss. But I think we are," said Edwards. "And I think by the end of this talk, you'll kind of see how this can be reframed, more recently with respect to over-the-counter or direct-to-consumer hearing aids."

He segmented the hearing dysfunction market in two steps: First, the population was categorized based on whether or not they have a measurable hearing loss based on an audiogram. Then, those two groups were further classified into whether or not they say that they have difficulty hearing.

People in the HD-HL segment – those with measured hearing loss and who affirm that they experience hearing difficulty – are the ones "that really need to be considered as the viable market for hearing aids," said Edwards.

He further noted that within this segment, 50 percent already have a hearing aid, as opposed to other estimates that put that figure at only about 23 percent.

"So the number of people who need hearing aids but aren't getting them is actually a lot smaller than people think, which I think is goin g to be a little bit of a surprise for some of the new companies coming into the market waiting for OTC."

Edwards also addressed concerns that OTC hearing aids could replace audiologist-fitted devices, and that audiologists could eventually become obsolete.

"Pretty powerful questions. So what I want to convince you is that these are actually the wrong questions. These questions are actually based on a false premise, so in a sense, these are false questions."

For him, the right questions that audiologists should be asking are: "What are the unmet hearing needs of the different segments of the population?" and "Who has unmet needs that OTC hearing aids can address?"

The most viable market for OTC devices is only one fraction of Edwards's population model. The other population segments, even those that are already using hearing aids, will still need hearing care professionals.

Edwards cited surveys in the US, Sweden, and Australia which showed a strong cor relation between patients' good experience with their hearing aids, and the amount of care they received from audiology practitioners.

"So, the greater care that they got from their audiologist, the better they believe that they're doing with their hearing aid," stressed Edwards. "This is a pretty strong case for the fact that the audiologists are a critical component for success with this population."

Published: 10/26/2020 3:23:00 PM
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Singular Hearing Announces Early Release of HeardThat, an AI-powered Hearing Assistive App for iPhone

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Via Audiology

Singular Hearing, a subsidiary of Singular Software and creator of HeardThat, announced today it launched an early release of its HeardThat app for the iPhone. For those with hearing loss, noisy environments like shops and restaurant patios can make it nearly impossible to hold conversations. HeardThat turns iPhones into powerful hearing assistive devices to make voices more clear. 

 HeadThat's AI and machine learning software was built using thousands of hours of recor ded speech and noise to learn the difference between speech and ambient noise. Rather than amplifying or reducing all sound entirely, HeardThat separates speech from noise to deliver enhanced voice audio while minimizing background noise. 

Smartphones, like the iPhone, have the processing power, memory and battery life to support HeardThat's powerful algorithms, unlike small wearable hearing devices. The app works in conjunction with earphones or hearing aids when connected to the iPhone, either directly or via Bluetooth. 

"We've spent years researching, developing and fine-tuning HeardThat for those that have trouble conversing in noisy social situations," said Singular Hearing CEO Dr. Bruce Sharpe. "Nothing works quite like HeardThat does and we're thrilled to be able to deliver enhanced voice clarity to those who need it."

Editor's note: The original material was < /span>provided by Singular Hearing. The accuracy of information in this press release is the responsibility of the source, and opinions expressed are not necessarily the views of The Hearing Journal. Read more at bit.ly/Hjbreakingnews. 

Published: 10/27/2020 9:32:00 AM
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A retrospective survey of Chlamydia pneumoniae infection rates in paediatric patients from a single centre in Wuxi, China

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Journal of International Medical Research, Volume 48, Issue 10, October 2020.
ObjectiveTo provide some epidemiological data on Chlamydia pneumoniae infection rates in paediatric patients at a single centre in Wuxi, China.MethodsThis was a retrospective analysis of serum samples from paediatric patients (<12 years) with a respiratory tract infection (RTI) and who had been admitted to the Department of Paediatrics, Wuxi No.2 People's Hospital, China, from 01 January 2015 to 31 December 2016. C. pneumoniae IgM antibodies had been analysed using enzyme-linked immunosorbent assay (ELISA).ResultsOf the 3866 children (2073 boys, 1793 girls) with a RTI that provided serum samples, 19% were positive for C. pneumoniae IgM antibodies. Among these children, 56% were positive for other infections.ConclusionsChildren over 6 years of age with a RTI had a h igher C.pneumoniae infection rate than younger children and the infection rate was more common in winter months compared with other times of the year.
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Association of lower extremity function with nutritional status and number of drugs in patients with chronic heart failure

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Journal of International Medical Research, Volume 48, Issue 10, October 2020.
ObjectiveThis study was performed to investigate the physical performance parameters, including lower extremity function parameters, that may be risk factors for falls in patients with chronic heart failure.MethodsSeventy patients with stable chronic heart failure were included in this retrospective cross-sectional study. The five-repetition sit-to-stand test (5STS) time, Controlling Nutritional Status (CONUT) score, and number of drugs were assessed.ResultsSimple linear regression analysis revealed that the 5STS time was positively correlated with age, the CONUT score, and the number of drugs but was negatively associated with the handgrip force, quadriceps force, and quadriceps muscle thickness. Multiple linear regression analysis showed a significant association betw een the 5STS time and the CONUT score, quadriceps force, and number of drugs.ConclusionThe muscle strength, nutritional status, and number of drugs should be evaluated to prevent lower extremity weakness in patients with stable chronic heart failure.
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Early invasive strategy for non-ST elevation acute coronary syndrome: a meta-analysis of randomized, controlled trials

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Journal of International Medical Research, Volume 48, Issue 10, October 2020.
ObjectivePatients with non-ST elevation acute coronary syndrome (NSTE-ACS) benefit from coronary intervention, but the optimal timing for an invasive strategy is not well defined. This study aimed to determine whether an early invasive strategy (<12 hours) is superior to a delayed invasive strategy.MethodsTwelve studies of nine randomized, controlled trials of 8586 patients were included.ResultsThere were no significant differences in all-cause death (risk ratio [95% confidence interval]) (0.90, [0.77–1.06), re-myocardial infarction (re-MI) (0.95 [0.70–1.29]), major bleeding (0.97 [0.77–1.23]), and refractory ischemia (0.74 [0.53–1.05]) when we compared use of early and delayed invasive strategies. Furthermore, analysis of the effect of the chosen strategy on high-risk patients showed that the rate of composite death or re-MI was significantly decreased in patients with either a Global Registry of Acute Coronary Events (GRACE) risk score >140 or with elevated troponin levels (risk ratio 0.82 [0.72–0.92]; risk ratio 0.84 [0.76–0.93], respectively).ConclusionsThis meta-analysis shows that an early angiographic strategy does not improve clinical outcome in patients with NSTE-ACS. An early invasive strategy might reduce the rate of composite death or re-MI in high-risk patients with GRACE risk scores >140 or elevated cardiac markers.
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Therapeutic effect of concentrated growth factor preparation on skin photoaging in a mouse model

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Journal of International Medical Research, Volume 48, Issue 10, October 2020.
ObjectiveTo establish a nude mouse model of photoaging and study the therapeutic effect of a concentrated growth factor preparation (CGF) on skin photoaging.MethodsCGF was prepared from blood from Sprague–Dawley rats. A skin photoaging nude mouse model was developed using UV irradiation combined with the photosensitizer, 8-methoxypsoralen. Mice were divided randomly into seven groups (n = 6 per group): normal control, photoaging, mock treatment, saline treatment, CGF treatment, Filoca 135HA treatment, and plasma skin regeneration system irradiation (the latter two were positive controls). Body weight and skin appearance were observed and pathological changes were determined by hematoxylin and eosin staining. Fiber elasticity was evaluated by Weigert staining. Expr ession levels of proliferating cell nuclear antigen (PCNA) and matrix metalloproteinase 1 (MMP1) were determined by immunohistochemistry.ResultsA mouse model with typical features of photoaging skin was successfully developed. CGF significantly improved the skin appearance, wrinkle scores, pathological changes, and fiber elasticity, and increased PCNA and decreased MMP1 expression levels in photoaging mice, comparable to the two positive controls.ConclusionCGF can improve the symptoms of skin photoaging in mice, suggesting that it may have applications in the treatment of skin aging in humans.
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Opioid-free anesthesia with a mixture of dexmedetomidine, ketamine, and lidocaine in one syringe for surgery in obese patients

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Journal of International Medical Research, Volume 48, Issue 10, October 2020.
Recently, there has been a trend toward minimizing opioid use in obese patients to prevent opioid-related postoperative complications. Moreover, the use of opioid-free anesthesia has received growing interest. This case series reports the use of simple opioid-free anesthesia consisting of a mixture of dexmedetomidine, ketamine, and lidocaine in an obese male patient undergoing laparoscopic bariatric surgery and an obese pregnant woman undergoing cesarean section. These cases indicate that opioid-free anesthesia can be safely administered to obese patients and provides effective pain control without any postoperative adverse outcomes.
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Healing effects of a protein scaffold loaded with adipose-derived mesenchymal stem cells on radiation-induced vaginal injury in rats

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Journal of International Medical Research, Volume 48, Issue 10, October 2020.
ObjectivesCervical cancer, the most common female cancer after breast cancer, is typically treated using radiotherapy. However, pelvic radiotherapy can cause irreversible damage to the vagina, seriously affecting patients' quality of life. In this study, protein scaffolds loaded with rat adipose-derived mesenchymal stem cells (ADSCs) were implanted into irradiated tissue to assess their healing potential.MethodsWe established a rat model of radiation-induced vaginal injury. Complexes (consisting of protein scaffolds loaded with ADSCs) were implanted into injury sites. Histological analysis were used to assess regeneration of the vaginal epithelium. RNA sequencing was used to study the therapeutic mechanism of the complexes.ResultsThe complexes promoted vaginal epithel ial cell regeneration, vaginal tissue repair and improved vaginal stenosis and contracture. Compared with rats transplanted with ADSCs, rats transplanted with complexes achieved better therapeutic effects.ConclusionsProtein scaffold-ADSC complexes had a beneficial therapeutic effect on radiation-induced vaginal injury in rats and may serve as the basis of a novel therapeutic approach for radiation dermatitis.
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