Comprehensive Role of SARS‐CoV‐2 Spike Glycoprotein in Regulating Host Signaling Pathway

alexandrossfakianakis shared this article with you from Inoreader Comprehensive Role of SARS‐CoV‐2 Spike Glycoprotein in Regulating Host Signaling Pathway Via Journal of Medical Virology Abstract Since the outbreak of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, global public health and the economy have suffered unprecedented damage. Based on the increasing related literatures, the characters and pathogenic mechanisms of the virus, epidemiological and clinical features of the disease are rapidly discovered. The spike glycoprotein (S protein), as a key antigen of SARS-CoV-2 for developing vaccines, antibodies, and drug targets, has been shown to play an important role in viral entry, tissue tropism, and pathogenesis. In this review, we summarize the molecular mechanisms of interaction between S protein and host factors, especially receptor-mediated viral modulation of host signaling pathways, and highlight the progression on potential therapeutic targets, prophylactic and therapeutic agents for prevention and treatment of SARS-CoV-2 infection. This article is protected by c opyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.