Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non-smokers

xlomafota13 shared this article with you from Inoreader Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non-smokers Via Experimental and therapeutic medicine Exp Ther Med. 2022 Mar;23(3):234. doi: 10.3892/etm.2022.11159. Epub 2022 Jan 21. ABSTRACT During the past few years, several studies have demonstrated that head and neck carcinomas present more aggressive forms for smokers, relative to non-smokers. Our aim was to investigate the tumor aggressiveness for patients with eyelid carcinomas, in relation to tobacco consumption, as well as other demographic and clinical data. For 98 patients with eyelid carcinomas, we studied the relationship between the duration of their symptoms and their tumor stage at first diagnosis, trying to determine potential correlations with smoking status and several other clinical parameters. Our data revealed that, for the same duration of symptoms, tobacco consumers tended to have higher tumor stages, which did not correlate with other variables. For early diagnosed tumors, within the first year of symptoms, smokers presented 6.044 times higher odds to exhibit m ore advanced tumor stages, compared to non-smokers, and this value decreased to 4.501, up to 5 years of the presence of symptoms (P<0.05). We also noted that, for smokers, an increased age was associated with increased tumor stages, which was opposed to non-smokers, regardless of their symptom duration [average odds ratio (OR) 1.122, P<0.05]. Tumor aggressiveness was therefore associated with tobacco consumption, leading to an increased risk of developing more aggressive forms of eyelid carcinomas for smokers, compared to non-smokers. PMID:35222711 | PMC:PMC8815059 | DOI:10.3892/etm.2022.11159 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.