Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta‐analysis

xlomafota13 shared this article with you from Inoreader Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta‐analysis Via Head & Neck Abstract The present study aims to estimate a pooled hazard ratio (HR) comparing overall survival (OS) for salvage surgery compared to nonsurgical management of recurrent head and neck squamous cell carcinoma (HNSCC). PubMed/MEDLINE and Embase-Ovid were searched on March 5, 2020, for English-language articles reporting survival for salvage surgery and nonsurgical management of recurrent HNSCC. Meta-analysis of HR estimates using random effects model was performed. Fifteen studies reported survival for salvage surgery and nonsurgical management of recurrence. Five-year OS ranged from 26% to 67% for the salvage surgery groups, compared to 0% to 32% for the nonsurgical management groups. Six studies reported HRs comparing salvage surgery to nonsurgical management; the pooled HR was 0.25 (95% CI [0.16, 0.38]; p < 0.0001). Selection for salvage surgery was associated with one quarter of the mortality rate associated with nonsurgical management in light of confounding facto rs including subsite and treatment intent. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.