Skin Microbiome Alterations in Seborrheic Dermatitis and Dandruff: A Systematic Review

xlomafota13 shared this article with you from Inoreader Skin Microbiome Alterations in Seborrheic Dermatitis and Dandruff: A Systematic Review Via Experimental Dermatology Abstract Seborrheic dermatitis (SD) and dandruff (DF) are common chronic inflammatory skin diseases characterized by recurrent greasy scales, sometimes with erythema and itchiness. Although the exact pathophysiology of the disease is still unclear, current theories highlight the role of microbes on the skin surface in the pathogenesis of SD. Here, we conducted a systematic review to investigate the skin microbiome alterations in patients with SD/DF. We searched Medline/PubMed, Embase and Web of Science for research studies published in English between January 1st, 2000 and December 31st, 2020. A total of 12 studies with 706 SD/DF samples and 379 healthy samples were included in this study. The scalp and face were predominated by the fungi of Ascomycota and Basidiomycota and the bacteria of Actinobacteria and Firmicutes. In general, the included studies demonstrated an increased M. restricta/M. globosa ratio and a reduction in the Cutibaterium/S taphylococcus ratio in the setting of SD/DF. Staphylococcus was associated with epidermal barrier damage, including elevated levels of trans-epidermal water loss and pH, while Cutibacterium had a positive correlation with water content. Malassezia was also found to be related to an increased itching score and disease severity. Further studies focusing on the interactions between various microbes and the host and microbes can help us to better understand the pathogenesis of SD/DF. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.