Is Fas‐mediated apoptosis of melanocytes indispensable in vitiligo?

xlomafota13 shared this article with you from Inoreader Is Fas‐mediated apoptosis of melanocytes indispensable in vitiligo? Via Experimental Dermatology Abstract With interest, we have read the article by Jimbo et al. in Experimental Dermatology 1. The authors reported that the Fas pathway is involved in CD8+ T-lymphocyte-dependent depigmentation in a vitiligo mouse model. Tumor necrosis factor (TNF)-α and interferon, (IFN)-γ whose expression is elevated in lesional skin of vitiligo patients, synergistically upregulated Fas expression but suppressed Fas-mediated apoptosis of human melanocytes in vitro. While there is no doubt that vitiligo results in cell death of these cells we wondered if patients with mutations of the FAS gene are resistant to develop vitiligo. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.