Inhibitory gating of coincidence-dependent sensory binding in secondary auditory cortex

xlomafota13 shared this article with you from Inoreader Inhibitory gating of coincidence-dependent sensory binding in secondary auditory cortex Via cortical auditory Nat Commun. 2021 Jul 29;12(1):4610. doi: 10.1038/s41467-021-24758-6. ABSTRACT Integration of multi-frequency sounds into a unified perceptual object is critical for recognizing syllables in speech. This "feature binding" relies on the precise synchrony of each component's onset timing, but little is known regarding its neural correlates. We find that multi-frequency sounds prevalent in vocalizations, specifically harmonics, preferentially activate the mouse secondary auditory cortex (A2), whose response deteriorates with shifts in component onset timings. The temporal window for harmonics integration in A2 was broadened by inactivation of somatostatin-expressing interneurons (SOM cells), but not parvalbumin-expressing interneurons (PV cells). Importantly, A2 has functionally connected subnetworks of neurons preferentially encoding harmonic over inharmonic sounds. These subnetworks are stable across days and exist prior to experimental harmoni cs exposure, suggesting their formation during development. Furthermore, A2 inactivation impairs performance in a discrimination task for coincident harmonics. Together, we propose A2 as a locus for multi-frequency integration, which may form the circuit basis for vocal processing. PMID:34326331 | PMC:PMC8322099 | DOI:10.1038/s41467-021-24758-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.