Evaluation of animal models of Crohn's disease with anal fistula (Review)

xlomafota13 shared this article with you from Inoreader Evaluation of animal models of Crohn's disease with anal fistula (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Sep;22(3):974. doi: 10.3892/etm.2021.10406. Epub 2021 Jul 8. ABSTRACT Anal fistula is a common and serious complication of Crohn's disease (CD). A sufficiently suitable animal model that may be used to simulate this disease is yet to be established. The aim of the present review was to summarize the different characteristics and experimental methods of commonly used animal models of CD with anal fistula. Electronic databases were searched for studies reporting on the use of this type of animal model. A total of 234 related articles were retrieved, of which six articles met the inclusion criteria; these were used as references for the present review article. The characteristics of the animal models, the advantages and disadvantages of the modeling methods and the similarities with patients with CD and anal fistula were summarized and analyzed. The evidence suggests that a sufficiently suitable animal preclinical model requires to be established. PMID:34335916 | PMC:PMC8290422 | DOI:10.3892/etm.2021.10406 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.