The problem surrounding the management of chronic rhinosinusitis with nasal polyposis (CRSwNP) has captivated practitioners for over 2 millennia. Derived from the Greek word πωλυποζ (pôlupos), meaning many feet, like an octopus, Hippocrates was among the first physicians to describe nasal polyposis and propose remedies including topical honey, iron cauterization, and snare polypectomy in his fabled text Diseases II.1 As understanding of CRSwNP pathophysiology expanded over time, modern treatment principles revolved around topical medications including intranasal corticosteroids and saline irrigations, as well as systemic drugs such as oral corticosteroids and antimicrobials for symptomatic flares.
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