Cell therapy and delivery strategies for spinal cord injury

xlomafota13 shared this article with you from Inoreader Cell therapy and delivery strategies for spinal cord injury Via Cellular and Molecular Biology Histol Histopathol. 2021 Jun 10:18350. doi: 10.14670/HH-18-350. Online ahead of print. ABSTRACT Spinal cord injury (SCI) is a complex neuropathological condition that represents a major challenge for clinicians and scientists due to patient's functional dysfunction and paralysis. Several treatments have been proposed including biological factors, drugs and cells administered in various ways. Stem cells arise as good candidates to treat SCI since they are known to secrete neurotrophic factors, improving neuroregeneration, but also due to their role in modulating the inflammatory process, favoring a pro-regenerative status. There are several types of cells that have been tested to treat SCI in experimental and clinical studies, but we still face many unanswered questions; one of them is the type of cells that can offer the best benefits and, also the ideal dose and administration routes. This review aimed to summarize recent research on cell treatment, focusing on current delivery strategies for SCI therapy and their effects in tissue repair and regeneration. PMID:34109994 | DOI:10.14670/HH-18-350 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.