Analysis of Gabapentin's Efficacy in Tinnitus Treatment: A Systematic Review

xlomafota13 shared this article with you from Inoreader Analysis of Gabapentin's Efficacy in Tinnitus Treatment: A Systematic Review Via otol rhinol Ann Otol Rhinol Laryngol. 2021 May 26:34894211018921. doi: 10.1177/00034894211018921. Online ahead of print. ABSTRACT OBJECTIVES: Tinnitus can be a chronic symptom that brings disability and distress. Some studies suggested that gabapentin might be effective on tinnitus relief. The objective of the study is to perform a systematic review in order to evaluate the efficacy of oral gabapentin in patients with tinnitus. METHODS: A literature search was conducted in English and following the recommendations from PRISMA. The terms used were: ("tinnitus" OR "subjective tinnitus") AND ("gabapentin"). The study selection was performed following the eligibility criteria in accordance to the PICOS (population, intervention, comparison, outcome, study design) strategy-patients with tinnitus; oral gabapentin; placebo; reduction of tinnitus severity questionnaires scores; prospective, double-blind, randomized controlled trial, respectively. The selected studies were included in qualitative synthesis. The studies were analyzed according to Joanna Briggs Institute's critical appraisal checklist for randomized controlled trials. RESULTS: One hundred twenty-one studies were found in 9 databases and 8 studies were found in gray literature. After study selection, 6 articles were read in full. Then, 2 studies were excluded and 4 were included in qualitative synthesis. All 4 articles were analyzed according to critical evaluation checklist. CONCLUSIONS: Th ere is insufficient evidence to recommend the use of gabapentin for patients with tinnitus. PMID:34036823 | DOI:10.1177/00034894211018921 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.