Objective The purpose of this study is to investigate the cortical activation during passive and active training modes under different speeds of upper extremity rehabilitation robots. Methods Twelve healthy subjects completed the active and passive training modes at various speeds (0.12, 0.18, and 0.24 m/s) for the right upper limb. The functional near-infrared spectroscopy (fNIRS) was used to measure the neural activities of the sensorimotor cortex (SMC), premotor cortex (PMC), supplementary motor area (SMA), and prefrontal cortex (PFC). Results Both the active and passive training modes can activate SMC, PMC, SMA, and PFC. The activation level of active training is higher than that of passive training. At the speed of 0.12 m/s, there is no significant difference in the intensity of the two modes. However, at the speed of 0.24 m/s, there are significant differences between the two modes in activation levels of each region of interest (ROI) (P
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