Vitamin C prevents epidermal damage induced by PM‐associated pollutants and UVA1 combined exposure

xlomafota13 shared this article with you from Inoreader Vitamin C prevents epidermal damage induced by PM‐associated pollutants and UVA1 combined exposure Via Experimental Dermatology Abstract Particulate matter is suspected to be substantially involved in pollution‐induced health concerns. In fact, ultrafine particles (UFPs) contain polycyclic aromatic hydrocarbons (PAHs) known as mutagenic, cytotoxic and sometimes phototoxic. Since UFPs reach blood circulation from lung alveoli, deep skin is very likely contaminated by PAHs coming from either skin surface or blood. As photoreactive, benzo(a)pyrene (BaP) or indenopyrene (IcdP) is involved in the interplay between pollution and sunlight. In order to better characterize this process, experiments were carried out on reconstructed human epidermis (RHE) in a protocol mimicking realistic exposure. Concentrations of PAHs comparable to those generally reported in blood were used together with chronic irradiation to low dose UVA1. On a histological level, damaged cells mainly accumulated in a suprabasal situation, thus reducing living epidermis thickness. Stress markers such as IL1‐α or MMP3 secretion increased, and surpri singly, the histological position of Transglutaminase‐1 within epidermis was disturbed, whereas position of other differentiation markers (keratin‐10, filaggrin, loricrin) remained unchanged. When vitamin C was added in culture medium, a very significant protection involving all markers was noticed. In conclusion, we provide here a model of interest to understand the epidermal deleterious consequences of pollution and to select efficient protective compounds. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.