Challenges of phototherapy for neonatal hyperbilirubinemia (Review)

xlomafota13 shared this article with you from Inoreader Challenges of phototherapy for neonatal hyperbilirubinemia (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Mar;21(3):231. doi: 10.3892/etm.2021.9662. Epub 2021 Jan 20. ABSTRACT Phototherapy is universally recognized as the first option for treating neonatal jaundice due to its unparalleled efficiency and safety in reducing the high serum free bilirubin levels and limiting its neurotoxic effects. However, several studies have suggested that phototherapy may elicit a series of short- and long-term adverse reactions associated with pediatric diseases, including hemolysis, allergic diseases, DNA damage or even cancer. The aim of the present review was to summarize the etiology, mechanism, associated risks and therapeutic strategies for reducing high neonatal serum bilirubin levels. In order to shed light on the negative effects of phototherapy and to encourage implementation of a reasonable and standardized phototherapy scheme in the clinic, the present review sought to highlight the current understanding of the adverse react ions of phototherapy, as it is necessary to further study the mechanism underlying the development of the adverse effects of phototherapy in infants in order to explore novel therapeutic alternatives. PMID:33613704 | PMC:PMC7859475 | DOI:10.3892/etm.2021.9662 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.