Role of Transforming Growth Factor‐β1 in Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma

xlomafota13 shared this article with you from Inoreader Role of Transforming Growth Factor‐β1 in Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma Via Experimental Dermatology Abstract Squamous cell carcinoma (SCC) develops in more than 80% of individuals with the skin blistering disorder recessive dystrophic epidermolysis bullosa (RDEB). In contrast with UV‐induced SCC, RDEB‐SCC results from skin damage and has a high proliferative and metastatic rate with five‐year survival near zero. Our objective is to determine the mechanisms underlying the increased metastatic tendencies of RDEB‐SCC. RDEB‐SCC cultured cell lines were treated with RDEB and non RDEB fibroblast conditioned media and assayed for migration and invasion with and without small molecule inhibitors for TGFβ and other downstream signal transduction pathways. TGFβ1 secreted by RDEB dermal fibroblasts has been found to induce migration and invasion, and to increase expression of epithelial‐to‐mesenchymal transition markers in an RDEB‐SCC line. These effects were reversed upon inhibition of TGFβ signaling and its downstream pathways MEK/ERK, P38 kinase, and SMAD3. A number of small m olecule inhibitors for these pathways are in different phases of various clinical trials and may be applicable to RDEB‐SCC patients. Studying the mechanisms of the extreme form RDEB‐SCC may inform studies of other types of SCC, as well as lead to better therapies for RDEB patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.