Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) Gene Polymorphism (rs3087243) Is Related to Risk and Survival in Patients With Colorectal Cancer

xlomafota13 shared this article with you from Inoreader Cytotoxic T-lymphocyte Antigen-4 (<em>CTLA-4</em>) Gene Polymorphism (rs3087243) Is Related to Risk and Survival in Patients With Colorectal Cancer Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):969-975. doi: 10.21873/invivo.12339. ABSTRACT BACKGROUND/AIM: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), transiently expressed on T cells, plays a pivotal role in the negative feedback regulation of T-cell activation and proliferation. The aim of the present study was to examine the influence of CTLA-4 gene polymorphism rs3087243 on CRC susceptibility and long-term survival in Swedish patients with CRC. PATIENTS AND METHODS: Genotypes of 491 patients and 433 healthy controls were determined, using TaqMan single nucleotide polymorphism (SNP) assays based on polymerase chain reaction. RESULTS: Patients carrying allele A were found to be at a higher risk of CRC and this allele was found to be more common in patients with disseminated disease compared to localized disease in the right colon. Kaplan-Meier analysis of cancer-specific survival showed that carriers of allele A had the highest risk of CRC -related death. CONCLUSION: The SNP rs3087243 of the CTLA-4 gene was associated with CRC risk and, therefore, it could be a prognostic marker for Swedish patients with CRC. PMID:33622891 | DOI:10.21873/invivo.12339 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.