Oral Oncology

select article Brain metastasis in head and neck squamous cell carcinoma after immune check point inhibitors treatment
CorrespondenceNo access
Brain metastasis in head and neck squamous cell carcinoma after immune check point inhibitors treatment
Luigi Lorini, Marco Merlano, Lisa Licitra, Marco Ravanelli, Paolo Bossi
In Press, Corrected Proof, Available online 31 December 2020
Purchase PDF
select article Back to basics: Hematoxylin and eosin staining is the principal tool for histopathological risk assessment of oral cancer
CorrespondenceNo access
Back to basics: Hematoxylin and eosin staining is the principal tool for histopathological risk assessment of oral cancer
Alhadi Almangush, Antti A. Mäkitie, Ilmo Leivo
In Press, Corrected Proof, Available online 29 December 2020
Purchase PDF
select article Role of Pembrolizumab in recurrent or metastatic head and neck carcinoma
CorrespondenceNo access
Role of Pembrolizumab in recurrent or metastatic head and neck carcinoma
Raul Pellini, Flaminia Campo, Domenico Sergi, Federico Cappuzzo
In Press, Corrected Proof, Available online 29 December 2020
Purchase PDF
select article Palatine tonsil adenoid cystic carcinoma
CorrespondenceAbstract only
Palatine tonsil adenoid cystic carcinoma
Dmitry Tretiakow, Edward Mollin, Andrzej Skorek
In Press, Corrected Proof, Available online 26 December 2020
Purchase PDF
select article Submucosal oral squamous cell carcinoma of the tongue
CorrespondenceNo access
Submucosal oral squamous cell carcinoma of the tongue
Niccolò Lombardi, Elena M. Varoni, Laura Moneghini, Giovanni Lodi
In Press, Corrected Proof, Available online 24 December 2020
Purchase PDF
select article Retiform hemangioendothelioma of the mandible: A case report
CorrespondenceNo access
Retiform hemangioendothelioma of the mandible: A case report
Junjian Jiang, Xiaoguang Li, Fengshuo Zhu, Yue He
In Press, Corrected Proof, Available online 17 December 2020
Purchase PDF
select article In situ melanoma of oral cavity: Diagnosis and treatment of a rare entity
CorrespondenceAbstract only
In situ melanoma of oral cavity: Diagnosis and treatment of a rare entity
Diovana de Melo Cardoso, Daniela Brito Bastos, Daniela Micheline dos Santos, Sebastião Conrado-Neto, ... Daniel Galera Bernabé
In Press, Corrected Proof, Available online 17 December 2020
Purchase PDFArticle preview
Abstract
Abstract
Oral melanoma is an extremely aggressive and rare tumor. Commonly, oral melanomas are diagnosed as invasive tumors, which considerably reduces the chances of cure. In situ oral melanomas being exceedingly rare, which makes its clinicopathological and prognostic characteristics poorly known. Herein, we report a case of 67-year-old non-white woman with a large black patch on the maxillary alveolar mucosa. A biopsy was made and microscopical analysis revealed moderate atypical junctional melanocytic. Tumor cells were positive for S100 (Polyclonal), Melan-A (Clone A103) and Melanosome (HMB-45). The diagnosis of in situ oral melanoma was made and the patient was treated surgically with partial maxillectomy and rehabilitated with obturator prosthesis. Although extremely rare in situ melanomas should be considered in the differential diagnosis of non-invasive pigmented lesions of the oral mucosa.

select article Synchronous primary neoplasia in patients with p16 positive oropharyngeal carcinoma: Does the 2nd cancer really matters?
CorrespondenceNo access
Synchronous primary neoplasia in patients with p16 positive oropharyngeal carcinoma: Does the 2nd cancer really matters?
Pirabu Sakthivel, Sarath Raveendran, Smriti Panda, Chirom Amit Singh
In Press, Corrected Proof, Available online 13 December 2020
Purchase PDF
select article Maxillo-facial reconstruction following cancer ablation during COVID-19 pandemic in southern Italy
CorrespondenceFull text access
Maxillo-facial reconstruction following cancer ablation during COVID-19 pandemic in southern Italy
Raffaele Rauso, Fabrizio Chirico, Francesco Federico, Giovanni Francesco Nicoletti, ... Gianpaolo Tartaro
In Press, Corrected Proof, Available online 9 December 2020
Download PDFArticle preview
Abstract
Abstract
In COVID-19 pandemic era, one major concern is related to ensure optimal management to oncologic patients, even though a context of radical uncertainty. The aim of our effort is to guarantee high-quality and timely care, minimizing COVID-19 infection risk, according to our head and neck (HN) reconstructive mission, still more challenging because of the criticality of the period. Thus, our reconstructive decision algorithm is changed. Microvascular free flaps, reported to be the gold standard for surgical reconstruction, represent extremely specialized procedures necessitating an extended resource allocation not affordable in the adversities of the period. Therefore, we are obliged to define a paradigm shift in our approach, based on free-style reconstructive surgery principles of propeller flap concept. According to our experience, we believe that this viable and feasible surgical technique could represent a reconstructive landmark in this pandemic era, since any guideline is missing, besides HN reconstructive surgery is most likely heading towards a new reconstructive approach.

select article Reply to "Keynote 48: Is it really for everyone?"
CorrespondenceNo access
Reply to "Keynote 48: Is it really for everyone?"
Jonathan D. Schoenfeld, Geoffrey Fell, Robert I. Haddad, Lorenzo Trippa
In Press, Corrected Proof, Available online 1 December 2020
Purchase PDF
select article Medicinal treatment of oral submucous fibrosis: Why is research not still translated into actual practice?
CorrespondenceNo access
Medicinal treatment of oral submucous fibrosis: Why is research not still translated into actual practice?
Gargi S. Sarode, Sachin C. Sarode, Shankargouda Patil
In Press, Corrected Proof, Available online 24 November 2020
Purchase PDF
select article Treating sinonasal crusting and infection after palatal and sinonasal cancer resection with topical antibiotic irrigations
CorrespondenceNo access
Treating sinonasal crusting and infection after palatal and sinonasal cancer resection with topical antibiotic irrigations
Madeline Goosmann, Steven Chang, John Craig
In Press, Corrected Proof, Available online 23 November 2020
Purchase PDF
select article Two distinct TP53 mutations in HNSCC primary tumor: Only one circulates in the blood
CorrespondenceAbstract only
Two distinct TP53 mutations in HNSCC primary tumor: Only one circulates in the blood
Federica Ganci, Matteo Allegretti, Valentina Manciocco, Francesco Fiorentino, ... Giovanni Blandino
In Press, Corrected Proof, Available online 21 November 2020
Purchase PDF
select article Tracheostomy stomal seeding following oral cavity resection
CorrespondenceAbstract only
Tracheostomy stomal seeding following oral cavity resection
J.M. Hintze, C. Fitzgerald, B. Lang, J. O'Shea, ... P. Lennon
In Press, Corrected Proof, Available online 21 November 2020
Purchase PDFArticle preview
Abstract
Abstract
Background
Tracheal stoma recurrence following oral cavity surgery is exceedingly rare. Although several different mechanisms for this have been described, the pathogenesis still remains uncertain.

Methods
We present the case of a gentleman who presented 6-months following oral cavity SCC resection with a large fungating mass at his previous tracheostomy site, and also review the reported literature on this rare phenomenon.

Results
Four weeks after diagnosis of his recurrence he underwent a total laryngectomy, wide-local skin excision and reconstruction with a pectoralis major pedicled flap. He recovered well initially following his operation, however unfortunately contracted nosocomial SARS-Cov2 and succumbed from respiratory complications during his post-operative recovery.

Conclusion
Stomal recurrence after temporary tracheostomy for oral cavity malignancies are very rare. Previously reported management of these can vary from surgical to palliative treatment. Methods to prevent these include delaying tracheostomy until after surgical resection, packing the pharynx during resection and adjuvant radiotherapy.

select article Maxillary bone metastasis, as an early sign of breast cancer; an unusual & rare site of metastasis from the common cancer
CorrespondenceAbstract only
Maxillary bone metastasis, as an early sign of breast cancer; an unusual & rare site of metastasis from the common cancer
Irappa Madabhavi, Malay Sarkar, Chidanand Chavan, Mansi Trivedi
In Press, Corrected Proof, Available online 20 November 2020
Purchase PDFArticle preview
Abstract
Abstract
Oral cavity metastases are considered rare and represent approximately 1% of all oral malignancies. Due to their rarity and atypical clinical and radiographic appearance, metastatic lesions are considered a diagnostic challenge. In this article we present a rare, unusual & exceptional case of left maxillary mass which on further evaluation leading to diagnosis of left breast carcinoma with metastasis to isolated left maxillary bone. Sixty five year old postmenopausal woman of low socioeconomic status with good performance status presented with a 3 months history of progressive pain and swelling in the left maxillary region. Fine Needle Aspiration Cytology (FNAC) from the maxillary mass shows invasive ductal carcinoma. On further clinical, radiographic, and histopathological examination findings from the breast lesion confirmed the diagnosis of hormone receptor positive metastatic breast carcinoma. In view of painful metastatic maxillary lesion with breast disease she was managed with a palliative radiotherapy to the maxillary lesion and palliative chemotherapy with Doxorubicin-Cyclophosphamide and bhisphosphonate-Zolendronic acid. Patient responded very well to palliative radiotherapy and chemotherapy, in view of hormone receptor positive breast cancer, now she is on Tab. Anastrazole 1 mg once a day along with monthly Zolendronic acid injection since last 13 months without any symptoms of disease evolution. A high index of clinical thought of metastatic cancer to maxilla is necessary when evaluating patients who complain of maxillary pain and swelling without a history of pain or swelling in the head and neck & non-head and neck region. To the best of our knowledge, this is the first reported case of a metastatic isolated solitary maxillary bone metastasis presenting as an early sign of breast cancer.

select article Optimising elective neck dissection for early oral cancers
CorrespondenceNo access
Optimising elective neck dissection for early oral cancers
Deep Chakrabarti, Naseem Akhtar, Sumaira Qayoom, Shiv Rajan, ... Arun Chaturvedi
In Press, Corrected Proof, Available online 14 November 2020
Purchase PDF
select article Mammary analog secretory carcinoma of the thyroid gland: A rare cancer harboring <em>TRK</em> fusion
CorrespondenceAbstract only
Mammary analog secretory carcinoma of the thyroid gland: A rare cancer harboring TRK fusion
Nai-si Huang, Yi-ming Cao, Zhong-wu Lu, Qing Guan, ... Qing-hai Ji
In Press, Corrected Proof, Available online 12 November 2020
Purchase PDFArticle preview
Abstract
Abstract
Mammary analog secretory carcinoma (MASC), or secretory carcinoma of the thyroid is an extremely rare disease harboring ETV6–NTRK3 gene fusion with TRK activation. Here we report the twelfth case of MASC of the thyroid worldwide. A 36-year-old female was diagnosed with poor-differentiated thyroid carcinoma (PDTC). Pathology consultant and immunochemical workups showed the tumor cells were negative for TTF1, TG, PAX8, positive for S100, Vimentin, GATA-3, and focally positive for mammaglobin. Fluorescence in situ hybridization (FISH) assay using a dual-color break-apart probe showed ETV6 translocation t(12p13) (ETV6) was present and established the diagnosis of MASC. Next-generation sequencing (NGS) of a 47-gene panel identified exon 1–5 of ETV6 gene were fused with exons 15–19 of NTRK3 gene. The patient experienced three loco-regional recurrences within 12 months and eventually developed inoperable local disease as well as bilateral lung metastasis. She is currently receiving anti-TRK treatment with a follow-up time of 33 months. A literature review of MASC in the thyroid was also conducted.

select article TERT promoter mutation in patients with second primary of tongue squamous cell carcinoma
CorrespondenceAbstract only
TERT promoter mutation in patients with second primary of tongue squamous cell carcinoma
Evren Erkul, Ismail Yilmaz
In Press, Corrected Proof, Available online 12 November 2020
Purchase PDFArticle preview
Abstract
Abstract
It is well known that head and neck squamous cell carcinomas are characterized by genetic alterations, genomic instability and different immune defects and Telomerase reverse transcriptase promoter mutations have been found with high rates in patients with tongue squamous cell carcinomas. We presented a non-smoker, no alcohol consuming woman who had a second primary tongue SCC after four and a half years later of her first tongue SCC with TERT promoter mutation. The primary tumor and its recurrences in woman with tongue SCC who have never smoked and had no alcohol consumption may need to be differing from other tongue carcinomas. TERT promoter mutations may have a relation in etiopathogenesis of tumor and mutations need to be on mind in future studies.

select article BRAFV600E mutation in oral melanocytic nevus and oral mucosal melanoma
CorrespondenceAbstract only
BRAFV600E mutation in oral melanocytic nevus and oral mucosal melanoma
Taynara Asevedo Campos de Resende, Bruno Augusto Benevenuto de Andrade, Vanessa Fátima Bernardes, Bruna Pizziolo Coura, ... Ricardo Santiago Gomez
In Press, Corrected Proof, Available online 12 November 2020
Purchase PDF
select article Amelanotic melanoma presenting as a tongue tumor
CorrespondenceNo access
Amelanotic melanoma presenting as a tongue tumor
Ana Kober Leite, Marco Aurélio V. Kulcsar, Danielli Matsuura, Leandro Luongo Matos, Luiz Paulo Kowalski
In Press, Corrected Proof, Available online 11 November 2020
Purchase PDF

#

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Telephone consultation 11855 int 1193,