ABSTRACT
The practicing pathologist will see a wide variety of metastatic tumors to the skin, many of which are not easily identifiable as metastases through histopathologic exam or clinical history. Furthermore, primary origin of tumors thought to be metastatic may not be readily apparent through initial histopathologic exam alone. We report an unusual cutaneous metastasis of an HPV‐related oropharyngeal squamous cell carcinoma with histopathologic features that closely mimicked a primary cutaneous sweat gland carcinoma. Clinical correlation and tissue testing for human papilloma virus (HPV) allowed for the correct diagnosis. Testing for HPV may be considered for lesions of unknown primary with similar histopathology.
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