smiRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma.

p.aythelady61 shared this article with you from Inoreader smiRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma. Via Head and Neck Related Articles smiRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma. Genomics. 2020 Dec 03;: Authors: Wu ZH, Zhong Y, Zhou T, Xiao HJ Abstract Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor of the upper aerodigestive tract. The loss and gain of miRNA function promote cancer development through various mechanisms. RNA sequencing (RNA-seq) and miRNAs sequencing data from the Cancer Genome Atlas (TCGA) was used to show the dysfunctional miRNAs microenvironment and to provide useful biomarkers for miRNAs therapy. Seven miRNAs were found to be independent prognostic factors of HNSCC patients in the training cohort. A total of 60 target genes for these miRNAs were predicted. Nine target genes (CDCA4, CXCL14, FLNC, KLF7, NBEAL2, P4HA1, PFKM, PFN2 and SEPPINE1) were correlated with patient's overall survival (OS) outcomes. We identified novel miRNAs markers for the prognosis of head and neck squamous cell carcinoma. PMID: 33279650 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.