Isaacs syndrome: the frontier of neurology, psychiatry, immunology and cancer

alkiviadis.1961 shared this article with you from Inoreader Isaacs syndrome: the frontier of neurology, psychiatry, immunology and cancer Via Journal of Neurology, Neurosurgery & Psychiatry current issue A syndrome of continuous muscle-fibre activity Authors: Isaacs H Year published: 1961 Number of times cited: 480 Evolution of Isaacs syndrome from case studies that described continuous ectopic activity through to an understanding as a multisystem autoimmune condition Six decades ago, Dr Hyam Isaacs reported a new clinical syndrome in the Journal of Neurology, Neurosurgery and Psychiatry.1 Isaacs used the term 'syndrome of continuous muscle-fibre activity ' or the more descriptive 'armadillo disease' for the condition which now has become known as Isaacs syndrome or acquired autoimmune neuromyotonia. In his landmark series, Isaacs described a phenotype of progressive muscle stiffness, with widespread fasciculation leading to weakness. A key finding was continuous muscle activity on electromyography, occurring at rest and unaffected by local nerve blockade. The original report also detailed a number of unsuccessful treatment approaches, as well as an astonishing improvement produced by sodium diphenyl... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.