Chaihu Shugan San (CHSGS) is a traditional Chinese herbal formula that is often used in clinical practice to treat live Qi stagnation syndrome and depression.tempspacetempspaceFluoxetine is one of the commonly used drugs for the clinical treatment of depression.tempspacetempspaceThis study involved a comparison of CHSGS and fluoxetine on antidepression and regulating blood rheology effects with chronic restraint stress- (CRS-) induced depression rat models.tempspacetempspaceRats were induced depression models by CRS for 4 weeks.tempspacetempspaceUpon successful induction of depression in the rats, the animal was administered CHSGS at 0.6 g/kg/d, 1.2 g/kg/d, or fluoxetine 1.8 mg/kg/d to corresponding groups by gavage for 2 weeks.tempspacetempspaceThe changes of CRS rats were determined by behavior obs ervations and sucrose preference test and hypothalamic-pituitary-adrenal cortex (HPA) axis functional status.tempspacetempspaceThe changes in monoamine neurotransmitters and related indicators of blood status were detected by enzyme-linked immunosorbent assay (ELISA), blood rheometer, and other methods.tempspacetempspaceThe outcome shows that CHSGS is superior to fluoxetine in regulating the appearance and HPA axis function of model rats.tempspacetempspaceIn addition, CHSGS and fluoxetine have similar effects in improving blood rheology, and both can alleviate the hypercoagulable state of blood via the platelet 5-hydroxytryptamine receptor 2A (5-HT2A) pathway in rats of depression.tempspacetempspaceIt was also observed that CHSGS can improve the blood state of depressed rats by restoring liver coagulation-anticoagulation balance and endothelium-related functions.
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