Exploring emotional attachment to game charactersEngaging game characters are often key to a positive and emotionally rich player experience. However, current research treats character attachment in a rather generic manner with little regard for the differing emotional qualities that may characterize this attachment. To address this gap we conducted a qualitative online survey with 213 players about the game characters they are particularly fond of. We identify seven distinct forms of emotional attachment,...
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Use of immunotherapy and surgery for stage IV melanoma: BackgroundImmunotherapy for stage IV melanoma has dramatically changed the overall prognosis and treatment strategies. The aim of this study was to evaluate whether changes in systemic immunotherapy options have significantly altered surgical resection rates for patients with stage IV melanoma.MethodsThe National Cancer Database (2004‐2015) was used to perform a difference‐in‐difference analysis to evaluate whether the rate of surgical resection...
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Pathogenic variants in TNRC6B cause a genetic disorder characterised by developmental delay/intellectual disability and a spectrum of neurobehavioural phenotypes including autism and ADHD: BackgroundRare variants in hundreds of genes have been implicated in developmental delay (DD), intellectual disability (ID) and neurobehavioural phenotypes. TNRC6B encodes a protein important for RNA silencing. Heterozygous truncating variants have been reported in three patients from large cohorts with autism,...
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Diurnal variation in autonomic regulation among patients with genotyped Rett syndrome: BackgroundRett syndrome is a severe neurological disorder with a range of disabling autonomic and respiratory symptoms and resulting predominantly from variants in the methyl-CpG binding protein 2 gene on the long arm of the X-chromosome. As basic research begins to suggest potential treatments, sensitive measures of the dynamic phenotype are needed to evaluate the results of these research efforts. Here we test...
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JCM, Vol. 9, Pages 734: Epigenetic Modification of CFTR in Head and Neck Cancer: JCM, Vol. 9, Pages 734: Epigenetic Modification of CFTR in Head and Neck CancerJournal of Clinical Medicine doi: 10.3390/jcm9030734Authors: Yonghwan Shin Minkyoung Kim Jonghwa Won Junchul Kim Seog Bae Oh Jong-Ho Lee Kyungpyo Park Cystic fibrosis transmembrane conductance regulator (CFTR), a cyclic AMP (cAMP)-regulated chloride channel, is critical for secretion and absorption across diverse epithelia. Mutations...
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JCM, Vol. 9, Pages 737: Endoscopic Submucosal Dissection of Gastric Neoplastic Lesions: An Italian, Multicenter Study: JCM, Vol. 9, Pages 737: Endoscopic Submucosal Dissection of Gastric Neoplastic Lesions: An Italian, Multicenter StudyJournal of Clinical Medicine doi: 10.3390/jcm9030737Authors: Manta Galloro Pugliese Angeletti Caruso Zito Mangiafico Marmo Zullo Esposito Annibale Mutignani Conigliaro Endoscopic submucosal dissection (ESD) allows removing neoplastic...
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JCM, Vol. 9, Pages 747: Breast-Specific Gamma Imaging with [99mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers: JCM, Vol. 9, Pages 747: Breast-Specific Gamma Imaging with [99mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone BiomarkersJournal of Clinical Medicine doi: 10.3390/jcm9030747Authors: Nicoletta Urbano Manuel Scimeca Carmela Di Russo Elena Bonanno Orazio Schillaci...
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JCM, Vol. 9, Pages 743: Cerebral and Splanchnic Vein Thrombosis: Advances, Challenges, and Unanswered Questions: JCM, Vol. 9, Pages 743: Cerebral and Splanchnic Vein Thrombosis: Advances, Challenges, and Unanswered QuestionsJournal of Clinical Medicine doi: 10.3390/jcm9030743Authors: Nicoletta Riva Walter Ageno Cerebral vein thrombosis (CVT) and splanchnic vein thrombosis (SVT) are two manifestations of venous thromboembolism (VTE) at unusual sites. They have an incidence at least 25–50 times...
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JCM, Vol. 9, Pages 745: Enhanced Inflammation and Nitrosative Stress in the Saliva and Plasma of Patients with Plaque Psoriasis: JCM, Vol. 9, Pages 745: Enhanced Inflammation and Nitrosative Stress in the Saliva and Plasma of Patients with Plaque PsoriasisJournal of Clinical Medicine doi: 10.3390/jcm9030745Authors: Anna Skutnik-Radziszewska Mateusz Maciejczyk Iwona Flisiak Julita Krahel Urszula Kołodziej Anna Kotowska-Rodziewicz Anna Klimiuk Anna Zalewska Psoriasis is the most common...
09:59
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus [Immunology and Inflammation]Type III IFN lambdas (IFN-λ) have recently been described as important mediators of immune responses at barrier surfaces. However, their role in autoimmune diseases such as systemic lupus erythematosus (SLE), a condition characterized by aberrant type I IFN signaling, has not been determined. Here, we identify a nonredundant role for...Proceedings of the National Academy of Sciences...
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Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis [Immunology and Inflammation]Developing lymphocytes diversify their antigen receptor (AgR) loci by variable (diversity) joining (V[D]J) recombination. Here, using the micrococcal nuclease (MNase)-based chromatin accessibility (MACC) assay with low-cell count input, we profile both small-scale (kilobase) and large-scale (megabase) changes in chromatin accessibility and nucleosome occupancy in primary...
09:57
Impact of neutrophil-to-lymphocyte ratio in patients with EGFR-mutant NSCLC treated with tyrosine kinase inhibitorsSummary Background Exon 19 deletion and L858R point mutation in exon 21 of the epidermal growth factor receptor (EGFR) are the most commonly encountered mutations in patients with non-small cell lung cancer (NSCLC) and predict better clinical outcomes following treatment with EGFR-tyrosine kinase inhibitors (TKIs). The inflammatory indicator neutrophil-to-lymphocyte ratio (NLR) in peripheral...
09:56
Intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients
Phase 1 study to evaluate safety, tolerability and pharmacokinetics of a novel intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients: SummaryCisplatin is a widely used chemotherapy for the treatment of certain solid tumors. Ototoxicity and subsequent permanent hearing loss remain a serious dose-limiting side effect associated with cisplatin treatment. To date, no therapies have been approved to prevent or treat cisplatin-induced hearing loss (CIHL)....
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Safety and influence of a novel powder form of coconut inflorescence sap on glycemic index and lipid profilePublication date: Available online 9 March 2020Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Renny Mammen, Febi John, I.M. Krishnakumar, Balu Maliakel, Ratheesh Mohan, Bradley FleenorScienceDirect Publication: Bioactive Carbohydrates and Dietary Fibre14h
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Performance of a Single Layer of Clothing or Gloves to Prevent Dermal Exposure to PesticidesAbstractThe suitability, availability, and use of protective clothing are critical factors determining the actual dermal exposure (ADE) of operators and workers to pesticides. A realistic assessment of occupational exposure to pesticides requires information about the performance of protective clothing during everyday use. In this study, the performance of clothing or gloves has been investigated based on...
09:52
Managing Implementation of a Parental Support Programme for Obesity Prevention in the School Context: The Importance of Creating Commitment in an Overburdened Work Situation, a Qualitative StudyAbstract Health-related behaviours in children can be influenced by parental support programmes. The aim of this study was to explore barriers to and facilitators for the implementation of a parental support programme to promote physical activity and healthy dietary habits in a school context. We explored...
09:52
Validation of a neonatal skin color scaleAbstract Ethnic classification does not correlate well with skin tone. As there are no neonatal skin color scales, we aimed to create and validate one of our own. After creating the scale and briefly training our staff, we conducted a prospective, observational study to assess reproducibility and correlation of each scale color with the melanin and erythema indexes and transcutaneous bilirubin. The reliability of our color scale was measured using Kappa agreement...
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Time-scale mechanical behaviors of locust semi-lunar process cuticles under power amplification for rapid movementsPublication date: Available online 9 March 2020Source: Journal of BiomechanicsAuthor(s): Chao Wan, Zhixiu Hao, Stanislav N. GorbBiomechanics13hPositioning and baby devices impact infant spinal muscle activityPublication date: Available online 9 March 2020Source: Journal of BiomechanicsAuthor(s): Safeer F. Siddicky, David B. Bumpass, Akshay Krishnan, Stewart A. Tackett, Richard E. McCarthy,...
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A case with multiple accessory foramina of mandible in a fetus: AbstractIt is aimed to better recognize the mandibular variations by understanding the diversity and positions of accessory foramina better. Accessory formations on a full-term fetal mandible dissected for a mandibular study were examined under a microscope. To observe these formations more clearly, they were photographed with the help of a camera and microscope. In one of the mandibles dissected for a fetal mandibular study, a lateral...
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Feasibility, effectiveness, and safety of a novel cryo-balloon targeted lung denervation technique in an animal modelPublication date: Available online 9 March 2020Source: CryobiologyAuthor(s): Kun Wang, Jiaxing Sun, Wei Gao, Rongzhang Chen, Xiaodong Wu, Yanan He, Qian Guo, Xin Zhang, Qiang LiCryobiology13hDoes human oocyte cryopreservation effect equally on embryo chromosome aneuploidy?Publication date: Available online 8 March 2020Source: CryobiologyAuthor(s): Nataliia Buderatska, Juliia Gontar,...
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Our 10 Years' Experience in Breast Asymmetry CorrectionAbstract Background Breast asymmetry is a common problem in augmentation mammoplasty. The notorious different implant volume approach has been shown ineffective because of recurring breast asymmetry in course of time. A uniform approach to the correction of breast asymmetry is still unavailable. Methods Four hundred and two patients underwent breast asymmetry...Latest Results for Aesthetic Plastic Surgery13hInvited Discussion on: Post-Operative...
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Chest computed tomography in children with COVID-19 respiratory infectionAbstract Background Infection with COVID-19 is currently rare in children. Objective To describe chest CT findings in children with COVID-19. Materials and methods We studied children at a large tertiary-care hospital in China, during the period from 28 January 2019 to 8 February...Latest Results9mLung T1 mapping magnetic resonance imaging in the assessment of pulmonary disease in children with cystic fibrosis: a pilot studyAbstract...
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Applied Immunohistochemistry & Molecular Morphology - Published Ahead-of-Print,Ki-67 Proliferation Index in Breast Cancer as a Function of Assessment Method: A NordiQC ExperienceImmunohistochemical staining for Ki-67 is used to calculate a Ki-67 proliferation index (PI) that carries prognostic and predictive information in various cancers including breast carcinomas. Studies have documented challenges for observers to reproducibly estimate the Ki-67 PI. At present, no international consensus...
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Effects of nutraceutical intervention on serum proteins in aged rats: AbstractAging is associated with many pathophysiological changes that could lead to the onset of degenerative disease. Some of the physiological changes that occur with aging include increased inflammation and decreased stem cell proliferation, leading to decreased capacity for tissue regeneration and loss of function. In previous studies, we and others have found nutraceutical intervention to ameliorate some of the deleterious...
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Cancer Medicine,Identification of hub methylated‐CpG sites and associated genes in oral squamous cell carcinomaConstruction of comethylation network associated with oral squamous cell carcinoma status by WGCNA. Dendrogram of consensus module eigengenes obtained by WGCNA on the consensus correlation. Seven modules were generated after merging according to the correlation of modules. Abstract To improve personalized diagnosis and prognosis for oral squamous cell carcinoma (OSCC) by identification...
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Identification of hub methylated‐CpG sites and associated genes in oral squamous cell carcinoma: Construction of comethylation network associated with oral squamous cell carcinoma status by WGCNA. Dendrogram of consensus module eigengenes obtained by WGCNA on the consensus correlation. Seven modules were generated after merging according to the correlation of modules.AbstractTo improve personalized diagnosis and prognosis for oral squamous cell carcinoma (OSCC) by identification of hub methylated‐CpG...
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Latest Results for Aging Clinical and Experimental ResearchThe effects of dietary licorice flavonoid oil supplementation on body balance control in healthy middle-aged and older Japanese women undergoing a physical exercise intervention: a randomized, double-blind, placebo-controlled trialAbstract Aims In this study, the effects of licorice flavonoid oil (LFO) supplementation on mobility functions were evaluated in middle-aged and older women who underwent daily physical exercise. Methods The 73...
09:36
Surface bio-functionalization using plasma of Argon could alter microbiological and topographic surface analysis of dental implants?: Publication date: Available online 9 March 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Luigi Canullo, Tullio Genova, Paolo Pesce, Yasushi Nakajima, Daichi Yonezawa, Federico Mussano
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Latest Results,Novel Ag configurations decorated CuO hybrid electrode for high-performance asymmetric supercapacitorAbstract In situ integration of highly conductive metals into transitional metal oxide electrodes with enabling fast electron transfer kinetics is a plausible technique for improving electrochemical performances of electrode materials. Herein, for the first time, we demonstrate a rational configuration of conductive Ag flakes (FAg) that directly grown on CuO nanorods by in situ chemical...
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Latest Results,Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiationAbstract Purpose Ligand-dependent corepressor (LCoR) and receptor-interacting protein 140 (RIP140/NRIP1) play an important role in the regulation of multiple oncogenic signaling pathways and the development of cancer. LCoR and RIP140 form a nuclear complex in breast cancer cells and are of prognostic value in further prostate and cervical cancer....
09:35
A Variation in FGF14 Is Associated with Downbeat Nystagmus in a Genome-Wide Association Study: AbstractDownbeat nystagmus (DBN) is a frequent form of acquired persisting central fixation nystagmus, often associated with other cerebellar ocular signs, such as saccadic smooth pursuit or gaze-holding deficits. Despite its distinct clinical features, the underlying etiology of DBN often remains unclear. Therefore, a genome-wide association study (GWAS) was conducted in 106 patients and 2609 healthy controls...
09:34
Role of Homeodomain-Interacting Protein Kinase 2 in the Pathogenesis of Tissue Fibrosis in Keloid-Derived Keratinocytes: Corrigendum:
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Creating an Outpatient, Local Anesthetic Hand Operating Room in a Resource-Constrained Ghanaian Hospital Builds Surgical Capacity and Financial Stability: Introduction Expanding surgical capacity is very difficult in resource-constrained countries. Financial input and additional physical operating room space are needed. The surgical patient volume exists, but the lack of operating room time causes postponement of cases. Hand surgery is particularly important as it improves patient function and allows...
09:33
Analysis of Scars and Keloids by Focused Ion Beam/Scanning Electron Microscopy: Distinguishing Between Hypertrophic Scars and Keloids: Background Histological differentiation between hypertrophic scars (HSs) and keloids has been considered difficult. In this study, we analyzed differences in the 3-dimensional tissue architecture between HSs and keloids using focused ion beam/scanning electron microscopy (FIB/SEM).Methods Five specimens each of normal skin, normotrophic scars (NSs), HSs, and keloids...
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The Free Serratus-Rib Flap for Orbital Floor Reconstruction After Oncologic Resection: Introduction Maxillary cancer is relatively rare but devastating for those affected with the disease. For patients who require suprastructural or total maxillectomy for oncologic resection, the resection of the orbital floor can be challenging to reconstruct. The serratus-rib flap is a well-known and useful method of head and neck reconstruction, albeit infrequently used. However, the serratus-rib flap has not...
09:31
A Modified Technique Using Levator Aponeurosis–Müller Muscle–Reinforced Plication for Blepharoptosis Correction: Background Blepharoptosis is a common and challenging clinical problem for oculoplastic surgeons, and various surgical techniques have been used to correct ptosis. The aims of this study were to present the clinical results of a modified technique using levator aponeurosis–Müller muscle–reinforced plication for blepharoptosis correction and to demonstrate its advantages over conventional...
09:31
An Analysis of Specialty-Specific Microsurgical Head and Neck Reconstruction: A Look at a Single Institution and National Trends Over a Decade: Introduction Head and neck free flap (HNFF) reconstructions have historically utilized a multidisciplinary approach between otolaryngology head and neck surgery (OHNS) and plastic surgery (PS). However, there seems to be a trend toward both the extirpative and reconstructive portions being performed by OHNS. We aimed to elucidate the volume trend in HNFF...
09:30
Cancer,Association of adverse events and associated cost with efficacy for approved relapsed and/or refractory multiple myeloma regimens: A Bayesian network meta‐analysis of phase 3 randomized controlled trialsBackground Several new treatment options have been approved for relapsed and/or refractory multiple myeloma (RRMM). In this systematic review, associations of the efficacy of each approved regimen with adverse events (AEs) and the total cost per cycle were compared with a Bayesian network...
09:29
Allergy and Clinical Immunology,Neonatal Thymectomy in Children - Accelerating the Immunological Clock?The thymus is critical for central tolerance and diverse T-lymphocyte repertoire development, to provide lifelong defence against pathogens, whilst maintaining self-tolerance. Peak thymic output occurs in-utero, infancy and early childhood, diminishing throughout life. Infants with congenital heart disease requiring sternotomy, often undergo thymectomy to clear the surgical field. Longterm effects...
09:28
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents,Activation of TGF-β1 Pathway by SCUBE3 Regulates TWIST1 Expression and Promotes Breast Cancer ProgressionCancer Biotherapy and Radiopharmaceuticals, Volume 35, Issue 2, Page 120-128, March 2020.Cancer Biotherapy & Radiopharmaceuticals - Table of Contents8hlncRNA HAND2-AS1 Inhibits Liver Cancer Cell Proliferation and Migration by Upregulating SOCS5 to Inactivate the JAK-STAT PathwayCancer Biotherapy and Radiopharmaceuticals, Volume...
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AI can enhance accuracy of CT scans in emphysema,An artificial intelligence (AI) algorithm trained and tested on more than 10,000...Read more on AuntMinnieEurope.comRelated Reading: AI-assisted FDG-PET/CT advances lung nodule detection Russian AI detects lung cancer on CT in 20 seconds AI can assist in triaging abnormal chest x-rays RSNA launches AI challenge to detect pneumonia on x-rays AI can help distinguish lung nodules on CT scansAuntMinnieEurope.com Headlines2m
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Cancer Science,Circulating Epstein‐Barr virus microRNAs BART7‐3p and BART13‐3p as novel biomarkers in nasopharyngeal carcinomaAbstract EBV BamHI A rightward transcripts (BART) encode microRNAs (EBV‐miR‐BARTs) abnormally highly expressed in Nasopharyngeal carcinoma (NPC). This study aims to investigate the diagnostic and prognostic performance of miR‐BART7‐3p and miR‐BART13‐3p. Plasma levels of EBV DNA, miR‐BART7‐3p, and miR‐BART13‐3p were examined by quantitative PCR in 483 treatment‐naïve NPC patients...
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Injury Prevention Online First,Armed and prohibited: characteristics of unlawful owners of legally purchased firearmsBackgroundA substantial proportion of individuals who lawfully purchase firearms later become unlawful owners ('prohibited firearm owners'), usually following events associated with an increased risk for future violence. This high-risk population has not previously been described. We aimed to characterise all individuals in California's Armed and Prohibited Persons System (APPS),...
09:25
Histopathological Revision for Gastro-Entero-Pancreatic Neuroendocrine Neoplasms in Expert Centers: Does it Make the Difference?: Background: The histopathological correct diagnosis of gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) is crucial for treatment selection and prognostication. It is also very challenging due to a limited experience in non-expert centers. Revision of pathology is standard of care for most patients who are referred to NEN expert centers. Objectives: To describe...
09:24
Shaping of the female human brain by sex hormones – a review: Traditionally sex hormones have been associated with reproductive and developmental processes only. Since the 1950s we know that hormones can have organizational effects on the developing brain and initiate hormonal transition periods such as puberty. However, recent evidence shows that sex hormones additionally structure the brain during important hormonal transition periods across a woman's life including short-term fluctuations. during...
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Histopathology of parasellar neoplasms: The anatomical and histological complexity of the parasellar region, as well as the presence of embryonic remnants, determine the huge diversity of parasellar neoplasms. Some of them are only located in the parasellar region, whereas others can occur elsewhere, within or outside the central nervous system. Their spectrum ranges from histologically benign and low grade malignant to high-grade malignant tumours. Although rare, metastases can pose differential...
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Histopathology of parasellar neoplasms: The anatomical and histological complexity of the parasellar region, as well as the presence of embryonic remnants, determine the huge diversity of parasellar neoplasms. Some of them are only located in the parasellar region, whereas others can occur elsewhere, within or outside the central nervous system. Their spectrum ranges from histologically benign and low grade malignant to high-grade malignant tumours. Although rare, metastases can pose differential...
09:24
Duodenal neoplasms of gastric phenotype: reports of two cases and a brief review of literature: Duodenal neoplasms of gastric phenotype are uncommon epithelial neoplasms. Pyloric gland adenomas should be recognized as neoplasms with risk for transformation into invasive adenocarcinoma (Choi et al. 2018). Here we report the case histories of two male patients, who presented with duodenal polypoid lesion. Endoscopic polypectomy and endoscopic submucosal dissection were carried out, respectively. Histopathologically,...
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We don't know why so few covid-19 cases have been reported in Africa: Experts still don't know why so few coronavirus cases have been reported in Africa, despite the continent's large population and China being its top trading partner
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Autism isn't a defect – here's why we should embrace neurodiversity: After finding out she was autistic, Siena Castellon sparked a global school movement that celebrates neurodiversity, which now includes nearly half a million students
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Bacteria sacrifice themselves when under attack to save their colonies: Some bacteria sacrifice themselves when their colony is attacked by rivals, to save their relatives and make sure their shared genes are passed on
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Cancer Research Online First ArticlesBRD4 levels determine the response of human lung cancer cells to BET degraders that potently induce apoptosis through suppression of Mcl-1Lung cancer consists of approximately 80% non-small cell lung cancer (NSCLC) and 20% small cell lung cancer (SCLC) and remains the leading cause of cancer deaths worldwide despite advances in early diagnosis, targeted therapy, and immunotherapy. Thus, novel therapies are still urgently needed. Bromodomain and extra terminal...
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British Journal of Cancer - Issue - nature.com science feedsAn integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancerBritish Journal of Cancer, Published online: 11 March 2020; doi:10.1038/s41416-020-0780-3An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancerBritish Journal of Cancer - Issue - nature.com science feeds5hNon-inferiority randomised phase 3 trial comparing...
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Elevated plasma X-linked neuroligin 4 expression is associated with autismspectrum disorder: Objectives: In this study, we aimed to measure the plasma concentration of NLGN4 in children with autism compared to matched healthy controls, and to examine a possible correlation between the plasma NLGN4 level and the degree of severity of autism, and social impairment in the autistic patients. Subjects and Methods: In this study, 88 autistic patients aged 3–12 years and 33 age and sex-matched controls...
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International Journal of NanomedicineProspects for the Use of Upconverting Nanoparticles as a Contrast Agent for Enumeration of Circulating Cells in vivoInternational Journal of Nanomedicine5hImproving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids MethodInternational Journal of Nanomedicine1dDevelopment of Dual Functional Nucleic Acid Delivery Nanosystem for DNA Induced Silencing...
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Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR: Breast cancer is the cancer with the highest prevalence in women and is the number-one cause of cancer mortality worldwide. Cell transduction is a fundamental process in the development and progression of cancer. Modifications in various cell signalling pathways promote tumour cell proliferation, progression, and survival. The PI3K/Akt/mTOR pathway is an example of that, and it is involved in growth, proliferation,...
09:15
Relationship between Thyroid Hormone Levels and Crime Type: A Controlled Study in Prisoners: Various factors cause aggression, which can be related to imbalance of T3 and T4 hormones, which can act as neurotransmitters and are reported to be elevated during aggression. This indicates changes in the hypothalamic-pituitary-thyroid axis that cause long-term changes in aggressive behaviour, especially in criminals. Moreover, mental and behavioural disorders possibly occur in individuals with impairment...
09:14
Effects of Environmental pH on the Growth of Gastric Cancer Cells: Background. Proton pump inhibitor (PPI) and other acid-suppressing drugs are widely used in the treatment of gastrointestinal ulcer, upper gastrointestinal bleeding, gastritis, and gastric cancer (GC). About 80% of GC patients receive acid suppression treatment. PPI suppresses the production of gastric acid by inhibiting the function of H+/K+-ATPase in gastric parietal cells and raises the pH value to achieve therapeutic purposes....
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Comparison of Intravenous versus Topical Tranexamic Acid in Nondeformity Spine Surgery: A Meta-Analysis: Objective. Tranexamic acid (TXA), an antifibrinolytic agent, interferes with fibrinolysis and has been used for many years to reduce blood loss during spine surgery. The purpose of our meta-analysis was to compare the effect of intravenous versus topical administration of TXA in patients undergoing nondeformity spine surgery. Methods. We searched multiple databases, including PubMed, Embase, the...
09:13
Clinical and endoscopic characteristics of diffuse esophageal intramural pseudo-diverticulosis: AbstractIntroductionWith 250 published cases worldwide, diffuse esophageal intramural pseudo-diverticulosis (DEIPD) is a poorly understood disease. The aim of this study was to determine the prevalence of DEIPD in our own population, identify risk factors and clinical symptoms, and characterize its typical endoscopic signs.MethodsRetrospective search in our center's endoscopic and clinical database. Reviewing...
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JBC Papers in Press,4hStructure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability [Enzymology] Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a feature that is valuable in a biotechnology setting. However, extant P450 enzymes are typically relatively unstable with T50 values ~30–40 °C. Reconstructed ancestral cytochrome P450 enzymes tend to have...4h{gamma}-Hydroxybutyrate does not mediate glucose inhibition of glucagon...
09:08
Prevalence of hyperfunctioning thyroid nodules among those in need of fine needle aspiration cytology according to ATA 2015, EU-TIRADS, and ACR-TIRADS: AbstractPurposeGiven the large number of patients with thyroid nodules, improvement of the specificity of current ultrasound-based thyroid nodule classification systems (ATA, EU-TIRADS, and ACR-TIRADS) is warranted to reduce the number of diagnostic thyroidectomies. Thyroid scintigraphy has been shown to demonstrate hyperfunctional nodules, associated...
09:08
Efficacy and Safety of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler in Chinese Patients with COPD: A Subgroup Analysis of KRONOS: AbstractIntroductionThis pre-specified subgroup analysis evaluated the efficacy and safety of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) triple therapy versus corresponding dual therapies in the China subgroup of the phase III, double-blind KRONOS study in patients with moderate to very severe chronic obstructive...
09:06
Evaluation of Nurse Preferences Between the Lanreotide Autogel New Syringe and the Octreotide Long-Acting Release Syringe: An International Simulated-Use Study (PRESTO): AbstractIntroductionSomatostatin analogues are used to treat symptoms and slow tumour progression in patients with neuroendocrine tumours (NETs) and carcinoid syndrome and to reduce hormone secretion and pituitary tumour volume in patients with acromegaly. A new syringe for lanreotide autogel/depot (LAN) was developed following feedback...
09:06
Tunnelized superior anterior auricular artery chondrocutaneous flap for tragal zone reconstruction after tumor excision: AbstractDespite the constitutional small size, the tragal zone plays an essential functional and morphological role. Little has been said about the tragal zone reconstruction after tumor excision in the literature. In this paper, we present a novel, smart, and safe idea to reconstruct the abovementioned anatomical region after a radical tumoral excision: the superior anterior auricular...
09:05
Cost-Effectiveness of Subsequent Whole-Brain Radiotherapy or Hippocampal-Avoidant Whole-Brain Radiotherapy Versus Stereotactic Radiosurgery or Surgery Alone for Treatment of Melanoma Brain Metastases: AbstractBackgroundA randomized phase III trial comparing whole-brain radiotherapy (WBRT) to observation following definitive local treatment of intracranial melanoma metastases with neurosurgery and/or stereotactic surgery (SRS) is underway.ObjectiveWe sought to assess the pre-trial cost-effectiveness...
09:05
Toxic inhalational injury: A middle-aged patient presented with toxic inhalational injury, and was resuscitated prehospitally and treated in the emergency department for smoke inhalation, carbon monoxide (CO) exposure and cyanide poisoning with the use of antidotes. Due to the CO effects on spectrophotometry, an anaemia initially identified on blood gas analysis was thought to be artefactual, but was later confirmed by laboratory testing to be accurate. In addition, cyanide can confound haemoglobin...
09:04
Bowel preparation agent inducing profound shock precolonoscopy: A 73-year-old woman was admitted to the intensive care unit following vomiting and diarrhoea onset after completing oral bowel preparation prior to colonoscopy to investigate haematochezia. She had a history of severe chronic obstructive pulmonary disease, Crohn's disease, diverticular disease, hypertension and dyslipidaemia. She was resuscitated with intravenous fluids, antibiotics and required epinephrine, norepinephrine and vasopressin...
09:04
Adult-onset methylenetetrahydrofolate reductase deficiency: Severe hyperhomocysteinemia (>100 µmol/L) is often associated with inborn errors of homocysteine metabolism. It manifests typically in neonatal period with developmental delay, hypotonia, feeding problems or failure to thrive. Adult-onset forms are rare and include less severe manifestations. Early diagnosis is crucial because effective treatment is available. A 23-year-old man presented with a 3-week history of speech and gait impairment,...
09:03
Medullary abscess: a rare clinical presentation: Brain abscesses represent areas of localised infection of the brain parenchyma. Those confined to the brainstem are rare and usually fatal if untreated. Streptococcus intermedius is a common causative organism of brain abscesses and is associated with significant morbidity. We describe a case report of medullary abscess secondary to dental infection in a 68-year-old patient. The patient presented with headaches and flu-like symptoms progressing to...
09:02
Prone positioning in a patient with fat embolism syndrome presenting as diffuse alveolar haemorrhage: new perspective: Diffuse alveolar haemorrhage (DAH) is a rare complication of fat embolism syndrome leading to severe hypoxaemia due to the effusion of blood into the alveoli from the damaged pulmonary microvasculature. The management is usually supportive with patients being nursed in supine position. The use of prone position ventilation in a DAH has rarely been reported before. We report an interesting...
09:02
Cerebellar ataxia a unique initial presentation of Legionnaires disease: We present a case of Legionnaires' disease complicated by cerebellar ataxia. A 60-year-old man was diagnosed with Legionnaires' disease by urine antigen after presenting to the hospital with a main problem of headache and gait instability. He also had a productive cough, as well as nausea, vomiting and diarrhoea. Initial physical examination revealed a positive Romberg test, positive pronator drift, severely unsteady gait and...
09:01
Fine-needle aspiration washout in the diagnosis of cystic parathyroid adenoma: Cystic parathyroid adenomas are one of the rare causes of neck masses. Due to its rarity, it causes misdiagnosis and wrong treatments and has undesirable consequences. The measurement of parathyroid hormone in fine-needle aspiration washout fluid is a minimally invasive, safe method for the diagnosis of parathyroid cysts and seems to be more useful than Tc-99m sestamibi (MIBI) parathyroid single photon emission computed...
09:01
Oral focal mucinosis of the palate: a rare disease entity: Oral focal mucinosis (OFM) is an extremely rare, benign oral soft tissue condition; less than 10 documented cases have been reported in the literature in patients under 18 years old. OFM has an unknown aetiology and predominantly presents in the fourth and fifth decades. The pathogenesis of OFM may be due to fibroblast overproduction of hyaluronic acid. Clinically, it remains almost impossible to diagnose definitively, due to its lack of...
09:00
Sample study protocol for adapting and translating the 5C scale to assess the psychological antecedents of vaccinationIntroductionPublished in 2018, the 5C scale is psychometrically validated to assess five psychological antecedents of vaccination (confidence, complacency, constraints, calculation and collective responsibility). The original version offers a validated English and German scale to assess these determinants with a short 5-item scale (1 item per antecedent) and a long 15-item scale (3...
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Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue: AbstractChronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the global early and late responses to a high-fat diet (HFD)...
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Caution and warning: Arrival of terbinafine‐resistant Trichophyton interdigitale of the Indian genotype, isolated from extensive dermatophytosis, in Japan:
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Outcomes of lymph node dissection in the treatment of extramammary Paget's disease: A single‐institution study: AbstractExtramammary Paget's disease (EMPD) often invades the dermis and metastasizes to the lymph nodes. Patients with EMPD associated with lymph node metastases have poor prognosis; to date, effective treatment has not yet been established. Lymph node dissection, aiming to control the local disease, is a standard form of management for EMPD patients with lymph node metastases (LNM). We...
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Abnormal keratinization and cutaneous inflammation in Mal de Meleda: AbstractMal de Meleda (MDM) is a rare, autosomal recessive form of palmoplantar keratoderma due to mutations in the gene, encoding for secreted lymphocyte antigen 6/urokinase‐type plasminogen activator receptor related protein 1 (SLURP1). We report a four‐year‐old Taiwanese MDM female case whose biopsy specimen of hyperkeratotic lesions showed abnormal keratinization and cutaneous inflammation with characteristic transmission electron...
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Educational Intervention Using WhatsApp on Medication Adherence in Hypertension and Diabetes Patients: A Randomized Clinical TrialTelemedicine and e-Health, Ahead of Print.Telemedicine and e-Health - Table of Contents2hPsychological Care Augmented by Telemedicine after a Polar Bear Encounter at an Arctic Research Station: A Case ReportTelemedicine and e-Health, Volume 26, Issue 3, Page 369-373, March 2020.Telemedicine and e-Health - Table of Contents1dThe Future of Virtual Care Services: A Payor's...
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The effects of maternal exposure to BPA during pregnancy on the male reproductive system and the testicular microRNA expression profile: AbstractThe effect of prenatal bisphenol A (BPA) exposure is increasingly concerned. We investigated the effect of maternal BPA exposure during pregnancy on male offspring and its potential mechanism. Thirty pregnant Sprague Dawley (SD) rats were randomly divided into exposed and control groups. At PND56, the number of sperm, luteinizing hormone, and testosterone...
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From an abdominal ultrasound to a lung disease passing through the diaphragm: a case of idiopathic pulmonary fibrosis: AbstractRationaleIdiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by abnormal and excessive deposition of collagen in the pulmonary interstitium (fibrosis) with minimal associated inflammation evolving into progressive and irreversible decline in lung function.Patient concernsPatient referred discomfort, bilateral upper quadrant abdominal pain, and progressive...
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International Journal of CancerCervical cancer burden in Latin America and the Caribbean: Where are we?In May 2018, the World Health Organization (WHO) called for the elimination of cervical cancer. To monitor this Initiative, we examined cervical cancer incidence and mortality in the Latin America and Caribbean (LAC) region using GLOBOCAN 2018, Cancer Incidence in Five Continents Series, and the World Health Organization Mortality Database. We estimated the number of cases and age‐standardized...
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Head and NeckUnilateral rhinorrhoea and button battery: a case report.Related ArticlesUnilateral rhinorrhoea and button battery: a case report. Fam Med Community Health. 2019;7(3):e000137 Authors: Tuang GJ, Nik Hussin NR, Zainal Abidin ZA Abstract Unilateral rhinorrhoea in the paediatric age group could be an alarming sign that warrants a clinician attention. These patients are routinely brought to see general practitioner as parents may not be aware of the urgency to intervene surgically. Herein...
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Rare CancersImportant surgical concepts and techniques in inguinal lymph node dissection.Related ArticlesImportant surgical concepts and techniques in inguinal lymph node dissection. Curr Opin Urol. 2019 05;29(3):286-292 Authors: Chipollini J, Garcia-Castaneda J, Harb-De la Rosa A, Cheriyan S, Azizi M, Spiess PE Abstract PURPOSE OF REVIEW: Penile cancer is a rare disease with significant physical and psychosocial morbidity. It has a propensity to spread to the inguinal lymph nodes where it can progress...
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American Medical Association College of American Pathologists,http://www.archivesofpathology.org/Counting Mitoses With Digital Pathology in Breast Phyllodes Tumors.Related ArticlesCounting Mitoses With Digital Pathology in Breast Phyllodes Tumors. Arch Pathol Lab Med. 2020 Mar 09;: Authors: Chow ZL, Thike AA, Li HH, Nasir NDM, Yeong JPS, Tan PH Abstract CONTEXT.—: Mitotic count is an important histologic criterion for grading and prognostication in phyllodes tumors (PTs). Counting mitoses is a routine...
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pubmed: epilepsy treatmentUnderstanding the Relationship Between Real-Time Thermal Imaging and Thermal Damage Estimate During Magnetic Resonance-Guided Laser Interstitial Thermal Therapy.Related ArticlesUnderstanding the Relationship Between Real-Time Thermal Imaging and Thermal Damage Estimate During Magnetic Resonance-Guided Laser Interstitial Thermal Therapy. World Neurosurg. 2020 Feb;134:e1093-e1098 Authors: Munier SM, Ginalis EE, Desai AN, Danish SF Abstract OBJECTIVE: Magnetic resonance-guided...
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pubmed: cell cycle arrestPrimary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma.Related ArticlesPrimary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma. Ageing Res Rev. 2019 07;52:53-63 Authors: Álvarez-Satta M, Moreno-Cugnon L, Matheu A Abstract Brain aging is characterized by a progressive loss of tissue integrity and function as a consequence of impaired homeostasis and regeneration capacities. The...
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pubmed: sleep apneaAlterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome.Related ArticlesAlterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome. J Ophthalmol. 2020;2020:4034382 Authors: Ucak T, Unver E Abstract Purpose: To analyze the effects of obstructive sleep apnea syndrome (OSAS) on ocular parameters and determine the alterations in macular vasculature by optical coherence tomography-angiography...
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Skull BaseSkull Base Parachordoma/Myoepithelioma.Related ArticlesSkull Base Parachordoma/Myoepithelioma. J Int Adv Otol. 2020 Mar 09;: Authors: Cates C, Borsetto D, Scoffings D, O'Donovan D, Donelly N Abstract Parachordoma is a rare soft tissue mixed tumor, associated with soft tissue myoepithelioma. It is typically growing slowly and considered less aggressive than other similar soft tissue tumors. However, it does recur sporadically, and on rare occasions, it has demonstrated the ability to metastasize....Skull...
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Nature Communications - current - nature.com science feedsCaliciviral protein-based artificial translational activator for mammalian gene circuits with RNA-only deliveryNature Communications, Published online: 10 March 2020; doi:10.1038/s41467-020-15061-xSynthetic RNA-based circuits allow for gene regulation without the risk of mutagenesis. Here the authors demonstrate a Caliciviral VPg-based Translational activator which allows translational activation of synthetic mRNAs.Nature Communications -...
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1.J Oral Rehabil. 2020 Mar 9. doi: 10.1111/joor.12959. [Epub ahead of print]International consensus on the most useful assessments used by physical therapists to evaluate patients with temporomandibular disorders: A Delphi study.von Piekartz H1, Schwiddessen J1, Reineke L1, Armijo-Olivio S2, Bevilaqua-Grossi D3, Biasotto Gonzalez D4, Carvalho GB5,6, Chaput E7,8, Cox E9,10, Fernández-de-Las-Peñas C11,12, Gadotti I13, Gil Martínez A14, Gross A15, Hall T16, Hoffmann M17, Julsvoll E18, Karegeannes M19, La...
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1.Ann Plast Surg. 2020 Apr;84(4):446-448. doi: 10.1097/SAP.0000000000001976.New Perspectives in Surgical Marking Since the Advent of Infrared Laser Angiography.Hammond JB1, Bryant LA, Casey WJ 3rd, Rebecca AM.Author informationAbstractINTRODUCTION:This study investigates the utility of common surgical dyes under direct visualization and infrared laser angiography.METHODS:Pigments affecting light within the visual (λ = 400-700 nm) and infrared (λ = 700-1000 nm) spectra were placed on subjects spanning...
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NeuroReport - Current IssuePerception of surface stickiness in different sensory modalities: an functional MRI studySurface texture can be perceived not only from tactile, but also from auditory and visual sensory cues. In our previous psychophysical study, we demonstrated that humans can recognize surface stickiness using only one kind of sensory modality without any difficulty. However, the brain regions that would be activated by non-corresponding sensory cues, for example, auditory and visual...
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Cancers, Vol. 12, Pages 638: c-MYC Expression Is a Possible Keystone in the Colorectal Cancer Resistance to EGFR InhibitorsCancers, Vol. 12, Pages 638: c-MYC Expression Is a Possible Keystone in the Colorectal Cancer Resistance to EGFR Inhibitors Cancers doi: 10.3390/cancers12030638 Authors: Antonia Strippoli Alessandra Cocomazzi Michele Basso Tonia Cenci Riccardo Ricci Francesco Pierconti Alessandra Cassano Vincenzo Fiorentino Carlo Barone Emilio Bria Lucia Ricci-Vitiani Giampaolo Tortora Luigi...
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Mucosal Immunology - Issue - nature.com science feedsThe emerging roles of eosinophils in mucosal homeostasisMucosal Immunology, Published online: 10 March 2020; doi:10.1038/s41385-020-0281-yThe emerging roles of eosinophils in mucosal homeostasisMucosal Immunology - Issue - nature.com science feedsTue Mar 10, 2020 02:00The emerging roles of eosinophils in mucosal homeostasisMucosal Immunology - Issue - nature.com science feedsTue Mar 10, 2020 02:00Mark above section as read Επιστημονικές Εξελίξεις...
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Case Reports in Infectious DiseasesNeisseria meningitidis as a Cause of Septic Arthritis: An Unusual Case of Periprosthetic Joint InfectionOne of the most feared complications after arthroplasty is infection due to its significant impact on patient morbidity. Infection may transfer to the joint at the time of surgery or be seeded, haematologically, to the prosthetic joint from another infection source. In this case, a 72-year-old female presented with symptoms of septic arthritis seven years after...
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Annals of Plastic Surgery - Current IssueLymphovenous Anastomosis for the Treatment of Thoracic Duct Lesion: A Case Report and Systematic Review of LiteratureBackground Chylous leak is an uncommon complication after head and neck surgery and typically results from a lesion of the thoracic duct (TD). Beside conservative treatment, different minimally invasive and surgical procedures exist, of which almost all lead to a total closure of the TD. Methods We report on a rare case of microsurgical lymphovenous...
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Evolutionary Biology News -- ScienceDailyHot time in the city: Urban lizards evolve heat toleranceFaced with a gritty landscape of metal fences, concrete walls and asphalt pavement, city lizards in Puerto Rico rapidly and repeatedly evolved better tolerance for heat than their forest counterparts, according to new research. Studies that delve into how animals adapt in urban environments are still relatively rare. But anoles are becoming a model system for urban evolutionary research.Evolutionary...
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The European Gastrointestinal Motility SocietyNormative values for gastric motility assessed with the 3D‐transit electromagnetic tracking systemThe Motilis 3D‐Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract. Using the 3D‐transit system, we have established normative values for gastric motility patterns. Gastric emptying time was not associated with age, gender, BMI, or the minor differences in the composition of the meal given with the capsule....
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Sprache · Stimme · GehörErkenntnisse, Trends und Entwicklung in der Stimmtherapie: im Jahre 2020 und darüber hinausSprache Stimme Gehör 2020; 44: 44-45DOI: 10.1055/a-0916-4197© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full textSprache · Stimme · GehörTue Mar 10, 2020 01:00Deletion 22q11Sprache Stimme Gehör 2020; 44: 58-59DOI: 10.1055/a-0916-4080© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full textSprache...
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Neuroradiology CasesTuberous Sclerosis MRI This CT and MRI study of brain shows:Multiple dense nodular calcifications along enpendymal lining of bilateral lateral ventricle best seen on CT. Cortical tubers seen as small multi focal cortical and sub cortical white matter patchy hypodensities on CT and T2 hyper intensities on MRI. No obvious obstructive hydrocephalus.The lesion at right caudo thalamic groove not calcified on CT but shows avid enhancement on post contrast, needs follow up imaging as...
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Nutrients, Vol. 12, Pages 727: The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western AlgeriaNutrients, Vol. 12, Pages 727: The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria Nutrients doi: 10.3390/nu12030727...
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Journal of Clinical Medicine,JCM, Vol. 9, Pages 744: Does Combining Biomarkers and Brain Images Provide Improved Prognostic Predictive Performance for Out-Of-Hospital Cardiac Arrest Survivors before Target Temperature Management?JCM, Vol. 9, Pages 744: Does Combining Biomarkers and Brain Images Provide Improved Prognostic Predictive Performance for Out-Of-Hospital Cardiac Arrest Survivors before Target Temperature Management? Journal of Clinical Medicine doi: 10.3390/jcm9030744 Authors: Seung Ha...
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International Journal of Environmental Research and Public Health,IJERPH, Vol. 17, Pages 1791: Housing Needs of Ageing Veterans Who Have Experienced Limb LossIJERPH, Vol. 17, Pages 1791: Housing Needs of Ageing Veterans Who Have Experienced Limb Loss International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051791 Authors: Gemma Wilson Gill McGill Alison Osborne Matthew D. Kiernan Military veterans can experience limb loss as a direct result of conflict, an accident,...
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Cells, Vol. 9, Pages 677: The Susceptibility of Retinal Ganglion Cells to Optic Nerve Injury is Type SpecificCells, Vol. 9, Pages 677: The Susceptibility of Retinal Ganglion Cells to Optic Nerve Injury is Type Specific Cells doi: 10.3390/cells9030677 Authors: Ning Yang Brent K Young Ping Wang Ning Tian Retinal ganglion cell (RGC) death occurs in many eye diseases, such as glaucoma and traumatic optic neuropathy (TON). Increasing evidence suggests that the susceptibility of RGCs varies to different...
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Antibiotics, Vol. 9, Pages 116: Is Caretta Caretta a Carrier of Antibiotic Resistance in the Mediterranean Sea?Antibiotics, Vol. 9, Pages 116: Is Caretta Caretta a Carrier of Antibiotic Resistance in the Mediterranean Sea? Antibiotics doi: 10.3390/antibiotics9030116 Authors: Alduina Gambino Presentato Gentile Sucato Savoca Filippello Visconti Caracappa Vicari Arculeo Sea turtles can be considered a sentinel species for monitoring the health of marine ecosystems, acting, at the same time, as a carrier...
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