1a17kr-s25tv.htmlAllergy_Immunology Update from NEJM.org.eml 2az5g2-skieq.htmlAeolian Research _ Volume 42.eml 3a4c5r-hewxc.htmlActa Biochimica et Biophysica Sinica Advance articles.eml 4akkit-m64w2.htmlAccepted Articles Alert_ Journal of Cutaneous Pathology.eml 5akwu8-w8f66.htmlAccepted Articles Alert_ Clinical and Experimental Dermatology.eml 6aauem-rapjz.htmlAccepted Articles Alert_ British Journal of Dermatology.eml 7aokj4-37w5f.html10 Ways to Reduce Mold Allergies.eml1ahrf5-ormn7.htmlClin Dermatol...
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Vision, mission and formulation of newer approaches and goals at IJA: The scientific journey will continueLalit Mehdiratta, Sukhminder Jit Singh BajwaIndian Journal of Anaesthesia 2020 64(1):1-3VISION 2020Muralidhar JoshiIndian Journal of Anaesthesia 2020 64(1):4-5The President's Inaugural Address during ISACON 2019, on 26th Nov. 2019 at Bengaluru - 'From history, to the Future'S Bala BhaskarIndian Journal of Anaesthesia 2020 64(1):6-8ISA academics – A new eraNaveen MalhotraIndian Journal of Anaesthesia...
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Viruses, Vol. 12, Pages 69: Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections: Viruses, Vol. 12, Pages 69: Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus InfectionsViruses doi: 10.3390/v12010069Authors: Pérez-Olmeda Sánchez-Seco Vázquez Balfagón de la Fuente Murillo Minguito de Ory The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose...
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American Brachytherapy Society working group report on the patterns of care and a literature review of reirradiation for gynecologic cancers: Publication date: Available online 6 January 2020Source: BrachytherapyAuthor(s): Alina Sturdza, Akila N. Viswanathan, Beth Erickson, Catheryn Yashar, Andrew Bruggemman, Jonathan Feddock, Ann Klopp, Sushil Beriwal, David Gaffney, Kathy Han, Mitchell KamravaAbstractPurposeRecurrences of previously irradiated gynecological malignancies are uncommon. Standardized...
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Implementation of peer-review quality rounds for gynecologic brachytherapy in a high-volume academic center: Publication date: Available online 6 January 2020Source: BrachytherapyAuthor(s): Minh-Phuong Huynh-Le, Aaron B. Simon, David J. Hoopes, John P. Einck, Catheryn M. Yashar, Daniel Scanderbeg, Dominique Rash, Derek Brown, Loren K. Mell, Parag R. Sanghvi, Arno J. Mundt, Todd Pawlicki, Jyoti S. MayadevAbstractPurposeWhile peer review is critical for quality and safety in radiotherapy, there are...
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Rosai Dorfman Disease: A Rare Cause of Bilateral Orbital Mass Lesions:A 36-year-old male presented with a 12-month history of progressive, painless, bilateral lower eyelid swelling. On examination, visual acuity was 6/9 in both eyes with normal pupil reflexes, unrestrained ocular motility, and no proptosis. Large, nontender, firm, fixed lower eyelid masses with rubbery consistency were identified (Fig. A), while anterior and posterior segment examination was otherwise normal. No palpable lymphadenopathy...
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Orbital Reconstruction via Deformable Titanium Mesh Following Spheno-Orbital Meningioma Resection: Ophthalmic Presentation and Outcomes: Purpose: To present a surgical approach to reconstruction of the bony orbit following resection of spheno-orbital meningioma utilizing deformable titanium mesh while emphasizing the ophthalmic presentation and outcomes of the repair.Methods: A retrospective chart review received International Review Board approval, and 20 patients met the inclusion criteria. All...
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Bilateral Punctal Foreign Body Granulomas Secondary to Multiple Retained Punctal Plugs: A 61-year-old female presented with a 3-month history of symmetric pink soft tissue masses from both inferior puncta (Fig. A). She had a history of dry eye and placement of 4 punctal plugs in each inferior punctum by her ophthalmologist. Bilateral excision and canaliculotomy revealed 4 retained punctal plugs in each inferior canaliculus (Fig. B). Histopathology (Fig. C,D, Hematoxylin & Eosin ×200, Hematoxylin...
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Blepharoptosis and Cholesterol-Lowering Medications: A Retrospective Study: Purpose: To investigate the prevalence and frequency of patients with blepharoptosis who take anticholesterol therapies. To our knowledge, this is the first large single-center series to evaluate this association.Methods: A retrospective chart review of adult patients presenting with ptosis on concomitant anticholesterol medications.Results: Two hundred ninety-three adult patients with ptosis taking anticholesterol therapy...
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Corneal Laceration Associated With Upper Eyelid Blepharoplasty: A 64-year-old woman underwent bilateral upper eyelid blepharoplasty and subsequently presented with decreased vision at her first postoperative visit 1 week later. She was found to have an 8-mm partial-thickness corneal laceration of her left eye and underwent immediate surgical laceration repair. The laceration etiology was thought to be related to damage from the initial blepharoplasty incision or Bovie cautery tip–induced laceration....
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The Microbiome of the Nasolacrimal System and Its Role in Nasolacrimal Duct Obstruction: Purpose: Acquired nasolacrimal duct obstruction (NLDO) is a common problem leading to epiphora, the pathophysiology of which remains unclear. Culture-based studies have found Staphylococcal species to be the most prevalent organisms, reported in 47% to 73% of patients with NLDO. Recently, culture-independent molecular methods of have allowed more comprehensive detailing of local microbiota. This study aims to...
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Lacrimal Drainage Anomalies in CHARGE Syndrome: Case Report and Review of Literature: The common ocular manifestations of CHARGE syndrome include colobomatous defects in the eye, strabismus, nystagmus, and micropthalmia. Lacrimal drainage anomalies have been rarely reported and to the best of the authors' knowledge, only 5 such cases have been reported earlier. The present case describes CHARGE syndrome associated with bilateral complex congenital nasolacrimal duct obstruction with multiple prior...
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Conjunctival Pediatric Follicular Lymphoma: Case Report and Literature Review: Follicular lymphoma (FL) is the second most commonly reported B-cell lymphoma and accounts for 6% of all orbital lymphomas. FL presentation in the pediatric population is rare. This study reported an 18-year-old male with a pink elevated lesion in the conjunctiva of the left eye and normal ocular parameters. Following a complete excisional biopsy, the lesion was oval and smooth grossly and showed dense proliferation with...
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Surgical Intervention of Periocular Infantile Hemangiomas in the Era of β-Blockers: Purpose: To examine the role of adjuvant surgical resection of infantile hemangiomas after systemic β-blocker therapy.Methods: This is a multicentered retrospective study. Standard protocol for oral propranolol was employed by the referring physicians. Ocular indications for surgery included ptosis obstructing the visual axis, high degrees of astigmatism causing amblyopia, or disfigurement from residual tumor. Patients...
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Ocular Adnexal Adenomatoid Sebaceous Gland Hyperplasia: A Clinical and Immunopathologic Analysis in Relation to the Muir-Torre Syndrome: The purpose of this study is to codify the microscopic diagnostic criteria for ocular adnexal brow and caruncular sebaceous gland hyperplasias (pseudoadenomatoid) that distinguish it from an adenoma. Clinical records and photographs were critically reviewed and microscopic slides were stained with hematoxylin and eosin and immunochemically stained for adipophilin,...
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Nasal and Lacrimal Sac Histopathology in Patients With Granulomatous Polyangiitis Undergoing Lacrimal Drainage Surgery: Purpose: To examine histological changes within nasal and lacrimal sac mucosa harvested from patients with granulomatous polyangiitis (GPA) who required lacrimal drainage surgery. As these patients were considered quiescent on clinical and serological grounds, particular attention was paid to the presence of active vasculitis.Design: Retrospective noncomparative case series.Participants:...
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Intracapsular High-Grade Ductal Carcinoma In-Situ Ex Pleomorphic Adenoma of the Lacrimal Gland: Primary ductal adenocarcinoma of the lacrimal gland is an aggressive neoplasm and can be seen either as a de novo malignancy or in the setting of a carcinoma ex pleomorphic adenoma. Carcinoma ex pleomorphic adenoma carries an overall unfavorable outcome; however, prognosis depends on the type and grade of the malignant component, presence of retained myoepithelial component, and extend of invasion beyond...
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Sarcoid Orbital Myopathy: Clinical Presentation and Outcomes: Purpose: To describe the clinical manifestations, systemic associations, radiological features, and treatment outcome for patients presenting with sarcoid-like granulomatous disease involving the extraocular muscles.Study design: Retrospective noncomparative case series and literature review.Methods: Patients presenting with presumed sarcoid orbital myopathy between 1990 and 2016 were classified either as having known systemic sarcoidosis...
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Endoscopic Evaluation of Lacrimal Mucosa With Indigo Carmine Stain: Purpose: Histological investigation in the use of indigo carmine for detection of mucosal pathology in lacrimal microendoscopy. To investigate the histopathological correlation of staining found on lacrimal microendoscopy.Methods: A prospective case series was conducted in patients with a history of nasolacrimal duct obstruction and dacryocystitis requiring treatment with dacryocystorhinostomy or dacryocystectomy. Prior to lacrimal...
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Valve of Rosenmüller: Endoscopic Real-Time Analysis of Two Subtypes and Potential Functional Implications: Purpose: The aim of this study was to examine the endoscopic anatomy of the valve of Rosenmüller in real-time and its potential functional implications.Methods: High-definition endoscopic documentation of the valve of Rosenmüller (VOR) during 50 powered endoscopic dacryocystorhinostomy over a period of 2 years were reviewed. The presence or absence of the valves were assessed and when present,...
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Glaucoma Filtering Bleb Analysis Before and After Aponeurotic Blepharoptosis Surgery: Purpose: To evaluate the effectiveness and safety of aponeurotic blepharoptosis surgery and the morphology of filtering bleb in patients with filtrating bleb.Methods: This retrospective case series included 7 consecutive patients (9 eyes) with filtering bleb after trabeculectomy. They underwent transcutaneous levator aponeurotic advancement from May 2018 to April 2019. The authors evaluated margin reflex distance-1...
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The "Bone Dry" Temporal Artery Biopsy Surgical Field in Giant Cell Arteritis:An 81-year-old white female presented with headache and visual loss. The past medical history was significant for type 2 diabetes, nonalcoholic fatty liver disease, diverticulosis, and asthma. The patient reported a 3-day history of "pixelated vision" in the left eye (OS) with shadows and a 2-month history of bilateral temporal headaches, jaw claudication, and scalp tenderness.External exam demonstrated cord-like, tender,...
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A Report of Intracranial Meningioma Recurring as Ectopic Orbital Meningioma Associated With Basal Encephalocele: The authors describe a rare case of recurrent ectopic meningioma associated with sphenoid encephalocele in the medial anterior orbit of a 52-year-old man with a history of a resected intracranial meningioma. Typical features of ectopic meningioma are reviewed as well as potential etiologies of this very rare recurrence of intracranial meningioma in the orbit. Treatment is typically surgical...
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A Modified Levator Resection to Improve Postoperative Lagophthalmos and Eyelid Lag: Purpose: To assess the effect of releasing the central attachment between the Whitnall's ligament (WL) and the levator palpebrae superioris muscle on the postoperative levator function (LF), eyelid lag, and degree of lagophthalmos.Methods: This retrospective case-control study included patients with moderate and severe simple congenital ptosis who underwent skin approach levator aponeurosis resection (LR) as a primary...
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Assessment of the Safety and Efficacy of Prolapsed Orbital Fat Resection During Involutional Entropion Repair: Purpose: To assess the recurrence rate of involutional entropion in patients treated with a combined approach including a modified Bick procedure, excision of preseptal orbicularis muscle, and conservative resection of prolapsed orbital fat.Methods: A retrospective chart review of patients undergoing repair of involutional entropion with the combined procedure including orbital fat resection...
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Orbital Diffuse Large B-Cell Lymphoma Initially Presenting as Neovascular Glaucoma: Orbital lymphoma can result in rapid loss of vision if not diagnosed and treated in a timely manner. This patient presented with rapid visual loss and on examination had a rubeosis iridis with a hyphema as well as neovascular glaucoma with vitreous hemorrhage. His medical history included systemic diffuse large B-cell lymphoma and a workup ultimately revealed an orbital mass in the body of the optic nerve. Optic nerve...
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Analysis of Periorbital Soft Tissue in Thyroid Eye Disease: Purpose: To investigate periorbital tissue enlargement in thyroid eye disease (TED) by 3-dimensional CT volumetric analysis.Methods: Twenty-four adult subjects, 16 with TED and 8 controls, were studied. Three-dimensional volumetric calculations were performed on CT imaging of the orbit and face, focusing on the retroorbicularis oculi fat, suborbicularis oculi fat, facial muscles in periorbital region, orbital fat, extraocular muscles, and...
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Long-Term Results of the Surgical Management of the Upper Eyelids in "Ablepharon"-Macrostomia Syndrome: Purpose: To describe the late results of the placement of skin graft over conjunctiva-Müller muscle complex in 3 patients with ablepharon-macrostomia syndrome (AMS) and to review the procedures used to manage the upper eyelids in AMS.Methods: The authors searched the Pubmed database for all articles that used the term "ablepharon-macrostomia syndrome" in any field. Data collection included description...
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Fibrous Dysplasia-like Lacrimal Sac Tumor Associated With Dacryocystitis: A 72-year-old woman who presented with right-sided epiphora and conjunctivitis underwent a probing and irrigation procedure with normal results. She improved with antibiotic-steroid drops. A swelling in the medial canthal region completely resolved. One year later, she returned with symptoms of dacryocystitis. An external dacryocystorhinostomy was performed. Characteristic dacryoliths were removed from the sac lumen, and biopsy...
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Serum Vitamin D Deficiency Is an Independent Risk Factor for Thyroid Eye Disease: Purpose: Thyroid eye disease (TED) is an inflammatory orbitopathy with significant impact on visual function and quality of life. Although studies have shown that patients who are deficient in vitamin D are more likely to develop autoimmune conditions, there are no studies demonstrating a definitive correlation between serum 25-hydroxyvitamin D (25(OH)D) deficiency and an increased risk of TED.Methods: This retrospective...
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Giant Bilateral Cysts of the Accessory Lacrimal Glands of Wolfring in a Child:Ductal cysts of the accessory lacrimal glands of Wolfring are rare clinical entities. They typically present as mobile and translucent lesions on the superior or inferior tarsal borders. Here, the authors describe a 7-year-old male child presenting with giant bilateral cysts of Wolfring. Management of such cysts is primarily surgical and the preferred route for excision is transconjunctival. To the best of the authors'...
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Orbital Bone Decompression for Non-Thyroid Eye Disease Proptosis: Purpose: To report a multicenter large case series of orbital decompression for non-thyroid eye disease proptosis.Methods: Retrospective chart review of cases of orbital decompression performed by 9 experienced orbital surgeons from different countries from 2014 to 2017 for non-thyroid eye disease proptosis. Patients were divided into 3 groups: 1) negative vector (high axial length or shallow orbit), 2) inflammatory, and 3) tumor....
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Histologic Evaluation of Nonvisual Afferent Sensory Upper Eyelid Proprioception: Purpose: Recent research has suggested a possible role for proprioception in ipsilateral frontalis activation in the setting of ptosis; however, there has not been any robust histologic or anatomic evidence to support this theory. To further elucidate proprioceptive structures in the eyelid, this investigation uses validated histologic techniques to explore the presence of proprioceptive structures or afferent neural...
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Orbital Glial Heterotopia: A Report of 2 Cases and Review of the Literature: Purpose: To review the clinical radiographic and histopathologic findings associated with orbital glial heterotopia.Methods: A literature search in PubMed and Scopus was performed to include all articles published in English between 1980 and January 1, 2019. A case series including 29 case reports of 29 patients, as well as the authors' 2 cases, were considered in the literature review.Results: The majority of the cases...
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Acute Unilateral Ptosis and Myositis Following the H1N1 Influenza Vaccine: The authors present a rare case of sudden onset unilateral complete ptosis occurring hours after administration of the H1N1 influenza vaccine. A complete workup for autoimmune and neurological disease was negative. MRI of the orbits demonstrated unilateral orbital myositis involving the left superior rectus/levator complex, superior oblique, and medial rectus muscles. Ptosis resolved spontaneously over 2 months without intervention....
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Gastrointestinal Dysfunction and Feeding Intolerance in Critical Illness: Do We Need an Objective Scoring System?: AbstractPurpose of ReviewEfforts to provide early enteral nutrition in critical illness are thwarted by gastrointestinal dysfunction and feeding intolerance. While many of the signs and symptoms of this dysfunction reflect gastroparesis and intestinal dysmotility, other symptoms which may or may not be related are often included such as diarrhea, bleeding, and intra-abdominal hypertension....
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Deep learning-based interpretation of basal/acetazolamide brain perfusion SPECT leveraging unstructured reading reports: AbstractPurposeBasal/acetazolamide brain perfusion single-photon emission computed tomography (SPECT) has been used to evaluate functional hemodynamics in patients with carotid artery stenosis. We aimed to develop a deep learning model as a support system for interpreting brain perfusion SPECT leveraging unstructured text reports.MethodsIn total, 7345 basal/acetazolamide brain...
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Breast Anthropometry—Results of a Prospective Study Among Indian Breast Cancer Patients: AbstractBreast anthropometry plays an important role in surgical decision-making in the era of breast conservation therapy, oncoplasty and reconstruction. Majority of the currently available breast anthropometry data is from Western countries, and there is a need to evaluate anthropometric data among Indian women to tailor our surgical decision-making and achieve optimum surgical results. Two hundred and thirty-one...
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Breast cancer screening disparities between women with and without disabilities: A national database study in South Korea: BackgroundHealth disparities among individuals with disabilities remain underrecognized. The objective of the current study was to investigate: 1) whether disparities exist in breast cancer screening rates among women with disabilities compared with women without disabilities; 2) whether breast cancer screening rates vary according to the type and severity of disabilities; and...
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Genomic and clinical characterization of stromal infiltration markers in prostate cancer: BackgroundThe progression of prostate cancer is a complex, multistep process that involves molecular alterations in cells of the tumor and the microenvironment, with associated interactions between the stroma and epithelium. Genomic expression analyses of stromal infiltration markers were performed to determine the significance thereof in prostate cancer.MethodsGenome‐wide expression profiles of formalin‐fixed,...
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Calcific Aortic Valve Stenosis and Atherosclerotic Calcification: AbstractPurpose of ReviewThis review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises.Recent FindingsLipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, and genetic driving forces such as mutations in LPA gene and NOTCH gene seem to play a major role in the development...
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Two Cases of Atraumatic Chylous Ascites Characterized by Hypotriglyceridemia and Partially Managed with an Oral Fat-Free Elemental Diet: Most cases of chylous ascites occur after surgery, but it also develops in nonoperative cases, although rarely. Such cases are often difficult to treat. In this study, we treated 2 cases of atraumatic chylous ascites, which were controlled by combining diuretic treatment with an oral fat-free elemental diet (Elental®, EA Pharma Co., Ltd., Tokyo, Japan). Elental...
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JCM, Vol. 9, Pages 155: Gold Nanoparticles Crossing Blood-Brain Barrier Prevent HSV-1 Infection and Reduce Herpes Associated Amyloid-βsecretion: JCM, Vol. 9, Pages 155: Gold Nanoparticles Crossing Blood-Brain Barrier Prevent HSV-1 Infection and Reduce Herpes Associated Amyloid-βsecretionJournal of Clinical Medicine doi: 10.3390/jcm9010155Authors: I MJ R FJ MJ MA Infections caused by HSV-1 and their typical outbreaks invading the nervous system have been related to neurodegenerative...
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Survival benefit of lymphadenectomy for gallbladder cancer based on the therapeutic index: An analysis of the US extrahepatic biliary malignancy consortium: AbstractBackground: The survival benefit of lymphadenectomy among patients with gallbladder cancer (GBC) remains poorly understood.Methods: Patients who underwent resection for GBC between 2000 and 2015 were identified from a US multi‐institutional database. The therapeutic index (LNM rate multiplied by 3‐year overall survival [OS]) was determined...
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Limb‐salvage surgery with vascular reconstruction after lower extremity sarcoma resection: A systematic review and meta‐analysis: AbstractBackgroundLimb‐salvage surgery with vascular reconstruction is the current standard treatment when sarcoma involves major vessels of the lower extremity. However, the low incidence of sarcoma and rarity of limb‐salvage surgery are limiting factors for the reliable study of limb‐salvage surgery. Therefore, a systematic review was conducted to establish better management...
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Treating and preventing recurrence of recurrent genital acquired lymphangiectasia using lymphaticovenous anastomosis at genital area: A case report: AbstractAfter the simple resection of genital acquired lymphangiectasia, a high recurrence rate is reported, as lymphatic fluid from the legs to the genital region continues. Here we report a case in which we treated and prevented recurrence of recurrent genital acquired lymphangiectasia with genital lymphaticovenous anastomosis (LVA). A 48‐year‐old...
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The effect of thymus transplantation on donor‐specific chimerism in the rat model of composite osseomusculocutaneous sternum, ribs, thymus, pectoralis muscles, and skin allotransplantation: AbstractIntroductionResearch on tolerance has proven that development of donor‐specific chimerism (DSC) may accompany tolerance induction in vascularized composite allotransplantation (VCA). In this study, we aimed to determine the effect of thymus transplantation on the induction of DSC in rat VCA model of osseomusculocutaneous...
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Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single‐center experience: AbstractBackground and ObjectivesGiant juvenile fibroadenoma (GJF) is a rare benign tumor that disfiguring affects the breast shape and quality of life of patients. This study aimed to report the experience of GJF management.MethodsA Wise‐pattern skin reducing tumor resection followed by immediate breast reconstruction with a dermal flap pocket was...
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EEG alpha activity increased in response to transcutaneous electrical nervous stimulation in young healthy subjects but not in the healthy elderly: Transcutaneous Electrical Nerve Stimulation (TENS) is used not only in the treatment of pain but also in the examination of sensory functions. With aging, there is decreased sensitivity to somatosensory stimuli. It is essential to examine the effect of TENS application on the sensory functions in the brain by recording the spontaneous electroencephalogram...
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Development of an autophagy-related gene prognostic signature in lung adenocarcinoma and lung squamous cell carcinoma: Purpose There is plenty of evidence showing that autophagy plays an important role in the biological process of cancer. The purpose of this study was to establish a novel autophagy-related prognostic marker for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Methods The mRNA microarray and clinical data in The Cancer...
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DNA methylation profiling in recurrent miscarriage: Recurrent miscarriage (RM) is a complex clinical problem. However, specific diagnostic biomarkers and candidate regulatory targets have not yet been identified. To explore RM-related biological markers and processes, we performed a genome-wide DNA methylation analysis using the Illumina Infinium HumanMethylation450 array platform. Methylation variable positions and differentially methylated regions (DMRs) were selected using the Limma package in...
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Systemic inflammation status at admission affects the outcome of intracerebral hemorrhage by increasing perihematomal edema but not the hematoma growth: AbstractAcute stress and inflammation responses are associated with worse outcomes in intracerebral hemorrhage (ICH) but the precise mechanisms involved are unclear. We evaluated the effect of neutrophil-to-lymphocyte ratio (NLR) in ICH outcome, with focus on hematoma expansion and early cerebral edema. In a retrospective study, we included all patients...
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A novel 311-nm Titanium:Sapphire laser therapy for alopecia areata: a pilot study of 19 patients:
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A comparison between EPSON V700 and EPSON V800 scanners for film dosimetry: AbstractRadiochromic film is a good dosimeter choice for patient QA for complex treatment techniques (IMRT, VMAT, SABR, SBRT) because of its near tissue equivalency, very high spatial resolution and established method of use. Commercial scanners are usually used for film dosimetry, among which EPSON scanners are the most common. NCCI have used an EPSON V700 scanner, but recently acquired a new model EPSON V800 scanner. The...
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Using a novel MR imaging sign to differentiate retinal pigment epithelium from uveal melanoma: AbstractPurposeRetinal pigment epithelium (RPE) adenoma is a rare intraocular benign tumor. It is almost always misdiagnosed as uveal melanoma (UM) resulting in inappropriate management. The purpose of this study was to investigate MRI features of the RPE adenoma that may help differentiate this entity from UM.MethodsMRI was performed in eight patients with pathology-proven RPE adenoma, five of whom had...
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Methotrexate plus or minus cetuximab as first‐line treatment in a recurrent or metastatic (R/M) squamous cell carcinoma population of the head and neck (SCCHN), unfit for cisplatin combination treatment, a phase Ib‐randomized phase II study Commence: AbstractBackgroundMethotrexate in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) has limited progression‐free survival (PFS) benefit. We hypothesized that adding cetuximab to methotrexate improves PFS.MethodsIn the...
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Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review: AbstractBackgroundNuclear protein in testis (NUT) carcinoma is a poorly differentiated carcinoma defined by the presence of NUT gene rearrangement. In the head and neck, the true prevalence of NUT carcinoma is unknown.MethodsWe retrospectively investigated NUT expression with clinicopathologic features in 362 patients of poorly differentiated or undifferentiated carcinomas in the head and neck, and reviewed...
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Prophylactic swallowing therapy for patients with head and neck cancer: A three‐arm randomized parallel‐group trial: AbstractBackgroundIntensive prophylactic swallowing therapy can mitigate dysphagia in patients with oropharyngeal (OP) SCC, however, presents service challenges. This trial investigated the clinical efficacy of three service models delivering prophylactic swallowing therapy during (chemo)radiotherapy ([C]RT).MethodsPatients (n = 79) with OPSCC receiving (C)RT were were randomized to:...
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Biomolecules, Vol. 10, Pages 96: The Role of Urocortins in Intracerebral Hemorrhage: Biomolecules, Vol. 10, Pages 96: The Role of Urocortins in Intracerebral HemorrhageBiomolecules doi: 10.3390/biom10010096Authors: Ker Woon Choy Andy Po-Yi Tsai Peter Bor-Chian Lin Meng-Yu Wu Chihyi Lee Aspalilah Alias Cheng-Yoong Pang Hock-Kean Liew Intracerebral hemorrhage (ICH) causes an accumulation of blood in the brain parenchyma that disrupts the normal neurological function of the brain. Despite...
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Protective Effects of Melatonin on Methamphetamine-Induced Blood–Brain Barrier Dysfunction in Rat Model: AbstractThe specialized brain endothelial cells interconnected by unique junctions and adhesion molecules are distinctive features of the blood–brain barrier (BBB), maintaining the homeostasis of the cerebral microenvironment. This study was designed to investigate the protective effects of melatonin on methamphetamine (METH)-induced alterations of BBB integrity. Wistar rats were randomly distributed...
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New Platinum-Based Prodrug Pt(IV)Ac-POA: Antitumour Effects in Rat C6 Glioblastoma Cells: AbstractGliomas are the most frequent primary tumours of the nervous system, characterised by high degree of malignancy, widespread invasion and high-rate proliferation. Cisplatin and analogue are currently employed in clinical trials as active chemotherapeutic agents for the systemic treatment of this type of malignancy. Despite therapy benefits, clinical use of these agents is hampered by severe side effects...
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Genome-Wide Association Study of Cerebral Microbleeds on MRI: AbstractCerebral microbleeds are the presence of a group of pathological processes affecting the small arteries, arterioles, capillaries, and venules of the brain. Previous studies showed that cerebral microbleeds were associated with higher risk of dementia and stroke. We conducted a genome-wide association study of cerebral microbleeds to identify novel loci associated with the presence and progression of cerebral microbleeds. This study...
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Omalizumab versus intranasal steroids in the post-operative management of patients with allergic fungal rhinosinusitis: AbstractPurposeAllergic fungal rhinosinusitis (AFRS) is a common disorder with a high prevalence and a very high incidence of recurrence. Management includes surgery and medical treatment in the form of local and/or systemic steroids. However, some cases are resistant to the action of steroids and further treatment is warranted. Being an immune-mediated disorder, targeting IgE seems...
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Pharyngeal reconstruction using a U-shaped pectoralis major myocutaneous flap: an effective technique that should not be forgotten: AbstractIntroductionAlthough free tissue transfer is thought the best option for head and neck reconstruction, the pectoralis major myocutaneous flap (PMMCF) remains an important alternative method. The aim of this study was to assess the use of the PMMCF with the prevertebral fascia to close a pharyngeal defect.Materials and methodsThis was a retrospective study of...
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Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population: AbstractObjectiveNasopharyngeal carcinoma (NPC) is a common malignancy in Southern China and Southeast Asia. Genetic susceptibility is a major contributing factor in determining the individual risk of NPC in these areas. To test the association between NPC and variants in regenerating gene 1A (REG1A), we conducted a hospital-based case–control study in a...
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Investigating the effects of inferior turbinate outfracture on the lacrimal system by evaluating the results of paranasal sinus computed tomography and nasolacrimal irrigation test: AbstractObjectivesThis study aims to investigate the effects of inferior turbinate outfracture on the nasolacrimal system and tear flow.MethodsForty-seven patients (26 males, 21 females) between the ages 18 and 52 years (mean age—29.0 ± 9.6 years) were included in the study. Preoperative nasal examinations and paranasal...
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Predictive factors for prolonged operative time in head and neck patients undergoing free flap reconstruction: Publication date: Available online 3 January 2020Source: American Journal of OtolaryngologyAuthor(s): Michael Lindeborg, Sidharth V. Puram, Rosh K.V. Sethi, Nicholas Abt, Kevin S. Emerick, Derrick Lin, Daniel G. DeschlerAbstractPurposeDefining the predictive factors associated with prolonged operative time may reduce post-operative complications, improve patient outcomes, and decrease cost...
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The effect of fibromyalgia treatment on tinnitus: Publication date: Available online 3 January 2020Source: American Journal of OtolaryngologyAuthor(s): O. Caglar Cil, C. Zateri, O. Guclu, S. Oymak, E. TezcanAbstractObjectivesWe investigated the frequency of tinnitus in fibromyalgia patients and the effect of drugs used for routine fibromyalgia on tinnitus.MethodsWe included 101 diagnosed fibromyalgia patients. After detailed ear nose throat examination, audiometric tests and tinnitus handicap index...
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Efficacy of nasal septal splints for preventing complications after septoplasty: A meta-analysis: Publication date: Available online 3 January 2020Source: American Journal of OtolaryngologyAuthor(s): Su Jin Kim, Dong Sik Chang, Myoung Su Choi, Ho Yun Lee, Jung-Soo PyoAbstractBackgroundThe efficacy of nasal septal splints, which are used as alternatives to nasal packs for preventing complications such as synechia and maintaining septal stability after septoplasty, remains controversial. The present...
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Omalizumab versus intranasal steroids in the post-operative management of patients with allergic fungal rhinosinusitis: AbstractPurposeAllergic fungal rhinosinusitis (AFRS) is a common disorder with a high prevalence and a very high incidence of recurrence. Management includes surgery and medical treatment in the form of local and/or systemic steroids. However, some cases are resistant to the action of steroids and further treatment is warranted. Being an immune-mediated disorder, targeting IgE seems...
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The vibrating ossicular prosthesis in children and adolescents: a retrospective study: AbstractPurposeThe primary objective of the retrospective study was to collect speech intelligibility data on children and adolescents implanted with the vibrating ossicular prosthesis (VORP) 503.MethodsThis was a retrospective, multicentre study on 55 children and adolescents from 6 German clinics aged between 5 and 17 years suffering from mixed or conductive hearing loss implanted with a VORP 503. Pre- and postoperative...
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Swallowing outcomes after pediatric epiglottopexy: AbstractIntroductionPersistent sleep apnea following tonsillectomy and adenoidectomy in children requires additional evaluation. One of the common areas of persistent upper airway obstruction in these children is the base of the tongue and lingual tonsils as well as epiglottic prolapse. Depending on the site of obstruction on sleep endoscopy or a cine MRI, surgical procedures include base of tongue reduction and lingual tonsillectomy with or without...
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Longstanding diplopia after ethmoidal artery ligation for epistaxis: AbstractPurposeIn the rare case of intractable, posterior, non-sphenopalatine artery epistaxis, ligation of ethmoidal arteries using an external approach like a Lynch-type incision is required. Orbital complications, especially extra-ocular motility disorders with diplopia, are known, but in the literature rarely described. Our aim was to analyse the complication type, rate, and outcome of ethmoidal artery ligation for epistaxis.Materials...
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Factors driving olfactory loss in patients with chronic rhinosinusitis: a case control study: BackgroundOlfactory dysfunction (OD) in chronic rhinosinusitis (CRS) is common. It is likely that numerous factors such as sex, race, age, allergies, asthma, smoking, and other comorbidities play a role in CRS‐related OD. In order to determine which aspects of OD are due solely to CRS and which are associated with other confounders, control populations are needed to allow appropriate risk assessments.MethodsProspective,...
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Redefining adequate margins in oral squamous cell carcinoma: outcomes from close and positive margins.: Related ArticlesRedefining adequate margins in oral squamous cell carcinoma: outcomes from close and positive margins.Eur Arch Otorhinolaryngol. 2020 Jan 02;:Authors: Jain PV, Sharan R, Manikantan K, Clark GM, Chatterjee S, Mallick I, Roy P, Arun PAbstract PURPOSE: Adequacy of surgical margins impacts outcomes in oral cancer. We sought to determine whether close and positive margins have...
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Dyna-CT of the temporal bone for case-specific three-dimensional rendering of the stapedial muscle for planning of electrically evoked stapedius reflex threshold determination during cochlear implantation directly from the stapedius muscle via a retrofacial approach: a pilot study.: Related ArticlesDyna-CT of the temporal bone for case-specific three-dimensional rendering of the stapedial muscle for planning of electrically evoked stapedius reflex threshold determination during cochlear implantation...
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Radiologic Contrast Media Desensitization for Delayed Cardiac Catheterization.: Related ArticlesRadiologic Contrast Media Desensitization for Delayed Cardiac Catheterization.Allergy Rhinol (Providence). 2019 Jan-Dec;10:2152656719892844Authors: Sanan N, Rowane M, Hostoffer RAbstract This protocol for rapid desensitization to intravenous radiographic contrast material (RCM) improves the strategy first reported by Uppal et al. Desensitization is a validated preventative measure for medical emergencies,...
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A Unilateral Nasal Mass With Generalized Seizures: Potential Diagnostic Pitfalls in Giant Pituitary Adenoma.: Related ArticlesA Unilateral Nasal Mass With Generalized Seizures: Potential Diagnostic Pitfalls in Giant Pituitary Adenoma.Allergy Rhinol (Providence). 2019 Jan-Dec;10:2152656719896580Authors: Aini R, Sachlin IS, Chee LC, Abdullah BAbstract Giant pituitary adenomas are clinically nonfunctioning adenomas, and the clinical presentation is usually secondary to compression of the neighboring...
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International Pediatric ORL Group (IPOG) Robin Sequence consensus recommendations.: Related ArticlesInternational Pediatric ORL Group (IPOG) Robin Sequence consensus recommendations.Int J Pediatr Otorhinolaryngol. 2019 Dec 28;130:109855Authors: Fayoux P, Daniel SJ, Allen G, Balakrishnan K, Boudewyns A, Cheng A, De Alarcon A, Goel D, Hart CK, Leboulanger N, Lee G, Moreddu E, Muntz H, Rahbar R, Nicollas R, Rogers-Vizena CR, Russell J, Rutter MJ, Smith RJH, Wyatt M, Zalzal G, Resnick CMAbstract ...
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Panel 2- recent advance in otitis media bioinformatics.: Related ArticlesPanel 2- recent advance in otitis media bioinformatics.Int J Pediatr Otorhinolaryngol. 2019 Dec 18;:109834Authors: Preciado D, Li JD, Komatsu K, Kurabi A, Nino G, Val S, Vijayasekaran S, Ziv O, Hermansson AAbstract OBJECTIVES: To update the medical literature on recent large-scale studies employing bioinformatics data analysis tools in otitis media (OM) disease models with a principal focus on developments in the past...
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Acoustic-articulatory configuration of women with vocal nodules and with healthy voice.: Related ArticlesAcoustic-articulatory configuration of women with vocal nodules and with healthy voice.Codas. 2019;31(6):e20180241Authors: França FP, Almeida AA, Lopes LWAbstract PURPOSE: To analyze the acoustic-articulatory configuration of vowels in women with vocal nodules and with healthy voice. METHODS: Twelve women with vocal nodules (EG) and twelve vocally health women (CG) participated...
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Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.: Related ArticlesGeneration, Coordination, and Evolution of Neural Circuits for Vocal Communication.J Neurosci. 2020 Jan 02;40(1):22-36Authors: Kelley DB, Ballagh IH, Barkan CL, Bendesky A, Elliott TM, Evans BJ, Hall IC, Kwon YM, Kwong-Brown U, Leininger EC, Perez EC, Rhodes HJ, Villain A, Yamaguchi A, Zornik EAbstract In many species, vocal communication is essential for coordinating social behaviors including...
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Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma - Case report and literature review.: Related ArticlesSuperior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma - Case report and literature review.Auris Nasus Larynx. 2019 Dec 31;:Authors: Tsukatani T, Niwa H, Komori T, Yoneyama T, Tsuji H, Michigishi T, Yokoyama K, Yoshizaki TAbstract Silicosis is caused by inhalation of silica dust and is the...
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Efficacy and related factors analysis in HMME-PDT in the treatment of port wine stains: Publication date: Available online 3 January 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Dan-chen Li, Nong Xiang, Hu Zhang-yi, Fang Tian-wen, Zhao Ting-ting, Sun Si-hao, LI YeABSTRACTObjectiveTo observe the efficiency and safety of hematoporphyrin mono-methylether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS) with Chinese patients, and to evaluate the advantage of photograph,VISIA...
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Prognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer.
Prognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer.: Related ArticlesPrognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer.Braz J Otorhinolaryngol. 2019 Dec 10;:Authors: Aslan H, Cekin G, Pinar E, Yazir M, Imre A, Songu M, Islek A, Aladag I, Oncel ISAbstract INTRODUCTION: 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters such as; maximum standardized uptake values,...
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Assessment of HPV 16, HPV 18, p16 expression in advanced stage laryngeal cancer patients and prognostic significance.: Related ArticlesAssessment of HPV 16, HPV 18, p16 expression in advanced stage laryngeal cancer patients and prognostic significance.Braz J Otorhinolaryngol. 2019 Dec 12;:Authors: Dogantemur S, Ozdemir S, Uguz A, Surmelioglu O, Dagkiran M, Tarkan O, Tuncer UAbstract INTRODUCTION: Human papilloma virus is an etiological risk factor for a subset of head and neck squamous cell...
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Motor and Sensory Rehabilitation of the Lower Lip: The lower lip serves pivotal functional and aesthetic roles in the face. Palsy of lower lip musculature may result in oral incompetence, articulation difficulties, and impairment of facial expression. Loss of lower lip sensation may result in unrecognized trauma, sialorrhea, and social embarrassment. Herein, we review therapeutic approaches to lower lip reanimation and sensory neurotization.
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Estlander Flap for Lip Reconstruction: Lip reconstruction following trauma or extirpative surgery remains a significant challenge to the facial plastic surgeon. Reconstructive efforts have attempted to balance aesthetic outcome with maintenance of function, while avoiding sequelae such as microstomia, oral commissure effacement, dry-wet lip substitution, adynamia, impaired lip sensation, and oral incompetence. Procedures include the eponymous Abbe, Estlander, Karapandzic, McGregor, and Gillies fan...
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Lip Reconstruction Using the Sabattini-Abbé Cross-Lip Flap: The lips are important anatomically distinct subunits within the lower face. Due to their prominence, and their location within an observational center of the face, even minor defects may result in conspicuous deformities.1 The lips serve a defining role in facial aesthetics, the concept of modern beauty and the expression of emotion. Functionally, the lips play an integral role in articulation and deglutition, due to their function as an...
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Free Flap Reconstruction of the Lip: Free tissue transfer is a critical tool for lip reconstruction. This section will discuss different aspects of free flap reconstruction. This type of reconstruction is primarily used for large skin and soft tissue defects typically involving greater than 80% of the lip. Both fasciocutaneous as well as muscular free flaps can be utilized for lip reconstruction. Free flaps can be utilized in non-dynamic as well as dynamic types of reconstruction. When free flaps...
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Facial Fillers in Lip Reconstruction: The lips are a critical aesthetic landmark of the lower face, and defects in this area have significant implications for functional and cosmetic symmetry. Facial fillers are commonly viewed as an adjunctive technique to surgical lip reconstruction but can also be used as a standalone, temporary management option for oral incompetence and contour defects. Facial fillers make use of a patient's existing perioral soft tissue framework while achieving immediate results...
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The Karapandzic Flap: The Karapandzic flap is a reliable reconstructive option for medium and large lip defects that maintains sensation and motor function and optimizes tissue vascularity.
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Commissuroplasty: Microstomia may arise from injury to the oral commissure or as iatrogenically after reconstruction of the lips. This process leads to inadequate oral competence, dysphagia, and dysarthria. Reconstruction of the oral commissure can be performed using basic commissuroplasty techniques. Implementation of basic methods for commissure reconstruction can be done safely and there are multiple variations to fit specific patient situations. The aim of this article is to describe the basic...
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Assessment of Chronological Volume Changes in Radial Forearm Free Flaps for Tongue Cancer: Objective: The radial forearm free flap (RFFF) is a commonly used free flap for tongue cancer. Postoperative changes in the volume of free flap are known to influence the functional restoration of the resected tongue. This study aimed to estimate chronological volume changes in RFFFs for tongue cancer and to determine the clinical factors affecting these changes. Methods: Clinical data for 19 patients who underwent...
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Characterization of the human helicotrema: implications for cochlear duct length and frequency mapping: AbstractBackgroundDespite significant anatomical variation amongst patients, cochlear implant frequency-mapping has traditionally followed a patient-independent approach. Basilar membrane (BM) length is required for patient-specific frequency-mapping, however cochlear duct length (CDL) measurements generally extend to the apical tip of the entire cochlea or have no clearly defined end-point. By...
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Inside Front Cover: Neurosurgical brain tumor detection based on intraoperative optical intrinsic signal imaging technique: A case report of glioblastoma (J. Biophotonics 1/2020): Intraoperative neurosurgical diagnosis of brain tumor determines the success rate of patients' prognoses. We firstly proposed a novel approach based on an optical method to distinguish the site of the tumor functionally. The promoted technique is non‐invasive, non‐radioactive, dye‐free, and potential of real‐time monitoring,...
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Inside Front Cover: Fast and sensitive delineation of brain tumor with clinically compatible moxifloxacin labeling and confocal microscopy (J. Biophotonics 1/2020): A new high‐speed cellular imaging method using clinically applicable moxifloxacin labeling, called as moxifloxacin based confocal microscopy (MBCM), was developed for fast and sensitive tumor detection and delineation. The MBCM demarcated malignant brain tumor from normal brain by visualizing dense and irregular cell distribution in the...
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Nuance in Bilateral Cleft Lip Repair: The management of patients with bilateral cleft lip and palate requires an understanding of anatomy and a focus on function. Comprehensive care in a collaborative multidisciplinary setting is crucial for the future development of these children. The operative technique begins with meticulous measurement and creation of symmetry to set the foundation for successful repair. In severely wide or asymmetric cases, preoperative orthopedics can be used to narrow the...
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Lip Reconstruction Using the Gillies Fan Flap: The Gillies Fan flap is a single-stage composite rotational-advancement flap for reconstruction of medium to large full thickness lower lip defects. It can be thought of as an extension of the Estlander flap. It is nourished by a narrow superiorly-based pedicle of the superior labial artery. Mobilized tissue includes adjacent lower lip tissue as well as tissue from the opposing lateral lip. The oral commissure is distorted with use of this technique,...
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Unilateral Cleft Lip Repair: Cleft lip is one of the most commonly encountered craniofacial deformities. While comprehensive management of this deformity requires a multidisciplinary team approach, this article will specifically focus on the surgical management of the unilateral cleft lip deformity. As evidenced by the multiple techniques that have been developed for its repair, a functionally and aesthetically pleasing result is challenging to attain. Optimal surgical repair requires a thorough...
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Lip Reconstruction: Primary Full Thickness Closure and Superficial Partial Thickness Closure: The lips play a principle role in the lower third of the face. Defects of the lips can result in profound functional and aesthetic consequences. Small to medium sized full thickness defects of the lip are amenable to primary closure and can yield excellent results. Partial thickness cutaneous defects may be amenable to local flap techniques or conversion to a full thickness defect for primary closure. By...
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Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis: Objectives/HypothesisGlutamine metabolism is a critical energy source for iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts, and glutaminase (GLS) is an essential enzyme converting glutamine to glutamate. We hypothesize that the GLS‐specific inhibitor BPTES will block glutaminolysis and reduce iLTS scar fibroblast proliferation, collagen deposition, and fibroblast metabolism in vitro.Study DesignTest‐tube...
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A Modern Case Sheds Light on a Classical Enigma: Beethoven's Deafness: Two hundred and fifty years have passed since the birth of Ludwig van Beethoven, and the enigma about his hearing loss and overall health status seems to be not completely solved. However, the admission to the hospital of a 64‐year‐old woman in 2018 with symptoms extremely similar to those experienced by the great composer may add further evidence to a theory previously underestimated. The health issues of the modern patient were...
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Flexible versus rigid laryngoscopy: A randomized crossover study comparing patient experience: ObjectivesTo compare flexible distal‐chip laryngoscopy (FDL) versus rigid telescopic laryngoscopy (RTL) in regard to examinees' pain level, comfort, satisfaction, and preference, and to evaluate the clinician's assessment of the examinees' experience with both exam types.Study DesignRandomized crossover study.MethodsTwenty‐three normal adult subjects were recruited to undergo both FDL and RTL; the initial...
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An Unusual Case Report of Malignant Melanoma of the Sphenoid Sinus with Review of Literature: AbstractNon skin malignant melanomas are known to be more aggressive than the skin counterpart. A 50-year lady with recurrent epistaxis, had mass in right sphenoid, which was resected by endoscopic sinus surgery. After histopathological confirmation of malignant melanoma radiotherapy was given. She later developed metastasis in liver.
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Cortical Brain Age from Pre-treatment to Post-chemotherapy in Patients with Breast Cancer: AbstractChemotherapy-related cognitive impairment and associated brain changes may reflect accelerated brain aging; however, empirical evidence for this theory is limited. The purpose of this study was to measure brain aging in newly diagnosed patients with breast cancer treated with chemotherapy (n = 43) and compare its longitudinal change to that of controls (n = 50). Brain age indices, derived from cortical...
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Ex Vivo Comparison of Antibacterial Efficacy of Conventional Chemomechanical Debridement Alone and in Combination with Light-Activated Disinfection and Laser Irradiation Against Enterococcus Faecalis Biofilm: Publication date: Available online 2 January 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Abdollah Ghorbanzadeh, Abbas Bahador, Pegah Sarraf, Roya Ayar, Reza Fekrazad, Sohrab AsefiAbstractBackground and objectivesIntracanal disinfection plays an important role in endodontic...
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Retinal microvasculature in the remission period of Behcet's uveitis: Publication date: Available online 2 January 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Funda E. Aksoy, Berna Basarir, Cigdem Altan, Isıl Pasaoglu, Aslı İnal, Ugur Tunç, Osman B. Ocak, Gamze O. KarabulutABSTRACTPurposeTo evaluate retinal microvasculature and blood flow during Behcet's uveitis (BU) remission via optical coherence tomography angiography (OCT-A), and compare the results with those from healthy eyes.MethodsA...
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Drug loaded essential oil Microemulsions towards enhancing photostability and evaluation of <em>in vitro</em> efficacy: Publication date: Available online 2 January 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Nisha Tiwari, Andrew Ebenazer, Jonathan Sampath Franklyne, A. Sivakumar, Amitava Mukherjee, N. ChandrasekaranAbstractLoss of stability of pharmaceutical APIs due to photolytic activity has been a major concern in the pharmaceutical industry as it leads to loss of...
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The effect of glucose and human serum on 5-aminolevulinic acid mediated photodynamic inactivation of <em>Candida albicans</em>: Publication date: Available online 2 January 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Irena Maliszewska, Dominika Wawrzyńczyk, Ewelina WanarskaAbstractIn response to the growing number of life-threatening infections caused by opportunistic Candida albicans fungi we have examined and discussed the effect of glucose and human serum on the efficiency...
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Photodynamic inactivation of oral bacteria with silver nanoclusters/rose bengal nanocomposite: Publication date: Available online 2 January 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Kanako Shitomi, Hirofumi Miyaji, Saori Miyata, Tsutomu Sugaya, Natsumi Ushijima, Tsukasa Akasaka, Hideya KawasakiAbstractAntibacterial photodynamic therapy (a-PDT) is a promising anti-infective technique for generation of singlet oxygen (1O2) to target dental disease. However, conventional organic...
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Daylight photodynamic therapy is an option for the treatment of actinic keratosis in patients with xeroderma pigmentosum in Africa: Publication date: Available online 2 January 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): M. Fernández-Guarino, D. Mavura, P. Fernández-González, P. Chapa, C. Ravazzano, L. Jaén, L. Rios, P. Jaén, H. GrossmanAbstractBackgroundXeroderma pigmentosum (XP) is a very rare and severe genetic disorder with a DNA repair defect of ultraviolet (UV)-induced damage....
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Rehabilitation of a Head and Neck Cancer Survivor With a Functionally and Biomechanically Challenged Dentition.: Related ArticlesRehabilitation of a Head and Neck Cancer Survivor With a Functionally and Biomechanically Challenged Dentition.Compend Contin Educ Dent. 2020 Jan;41(1):42-49Authors: Avondoglio DM, Pumphrey BJAbstract Radiation therapy for patients with head and neck cancer can have damaging effects on oral health, including reduced salivary flow. In this case report, a 58-year-old...
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Voice production in a MRI-based subject-specific vocal fold model with parametrically controlled medial surface shape.: Related ArticlesVoice production in a MRI-based subject-specific vocal fold model with parametrically controlled medial surface shape.J Acoust Soc Am. 2019 Dec;146(6):4190Authors: Wu L, Zhang ZAbstract The goal of this study was to investigate how realistic changes in medial surface shape, as occur in human phonation, affect voice production. In a parametric magnetic resonance...
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A novel, low fidelity simulator for laryngotracheal reconstruction.: Related ArticlesA novel, low fidelity simulator for laryngotracheal reconstruction.Int J Pediatr Otorhinolaryngol. 2019 Oct;125:212-215Authors: Kavanagh KR, Murray NAbstract INTRODUCTION: Open airway reconstruction is a highly specialized skill. Simulation affords the opportunity to practice surgical skills in a low stakes environment which is particularly important for a high acuity, low frequency operation. Although animal...
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Growth Media for Mixed Multispecies Oropharyngeal Biofilm Compositions on Silicone.: Related ArticlesGrowth Media for Mixed Multispecies Oropharyngeal Biofilm Compositions on Silicone.Biomed Res Int. 2019;2019:8051270Authors: Leonhard M, Zatorska B, Moser D, Schneider-Stickler BAbstract Aims: Microbial colonization of silicone voice prostheses by bacteria and Candida species limits the device lifetime of modern voice prostheses in laryngectomized patients. Thus, research focuses on biofilm...
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Low Cost, Easy-to-Replicate Myringotomy Tube Insertion Simulation Model: Publication date: Available online 3 January 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nicole Molin, Jerlon Chiu, Benjamin Liba, Glenn IsaacsonAbstractIntroductionSimulation is an established part of modern surgical education. Several training centers have proposed different simulation models for myringotomy tube (MT) placement and validated their effectiveness in medical student and resident...
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Spectro-temporal modulation detection and its relation to speech perception in children with auditory processing disorder: Publication date: Available online 3 January 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Younes Lotfi, Abdollah Moossavi, Parisa Jalilzadeh Afshari, Enayatollah Bakhshi, Hamed SadjediAbstractObjectivesPoor speech perception in noise is one of the most common complaints reported for children with auditory processing disorder (APD). APD is defined...
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Efficacy of Melatonin for Auditory Brainstem Response Testing in Children: A Systematic Review: Publication date: Available online 3 January 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): David B. Behrman, Jessica L. Bishop, Jeremy Godsell, Brian Shirley, Sarah Storey, William W. Carroll, John D. ProsserAbstractObjectiveTo examine the literature on pre-treatment with melatonin for successful completion of Auditory Brainstem Response (ABR) testing in pediatric patients...
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Endoscopic type 1 cartilage tympanoplasty in children: Publication date: Available online 2 January 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Engin Dursun, Emine Demir, Suat Terzi, Özlem Çelebi Erdivanlı, Zerrin Özergin Coşkun, Gökçe Aydın Balaban, Metin ÇelikerAbstractObjectivesEndoscopic type 1 tympanoplasty using cartilage grafts for repair of chronic tympanic membrane perforation is increasing. The aim of this study was to evaluate the results of endoscopic...
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Subannular Ventilation Tubes in the Pediatric Population: Clinical Outcomes of over 1000 insertions: Publication date: Available online 2 January 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nathan Yang, Pier-Luc Beaudoin, Michael Nguyen, Hélène Maillé, Anastasios Maniakas, Issam SalibaAbstractObjectivesLong-term transtympanic tube insertions for chronic middle ear disease are associated with high rates of complications. The objective of this study was to examine the...
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Outcome of Canal Wall Down Mastoidectomy: A Retrospective Review: AbstractA canal wall down mastoidectomy (CWDM) is an effective technique for eradication of chronic suppurative otitis media (atticoantral disease) or cholesteatomas. A retrospective study was conducted at R.D. Gardi Medical college between 2015 and 2017 to evaluate the outcome of CWDM for patients with atticoantral type of CSOM. All new cases of MRM/RM which fulfilled the selection criteria were reviewed. The main outcome measures...
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A Retrospective Analysis and Comparison of the STAM and STAMCO Classification and EAONO/JOS Cholesteatoma Staging System in Predicting Surgical Treatment Outcomes of Middle Ear Cholesteatoma: Objective: To evaluate and compare the STAM classification, STAMCO classification and the EAONO/JOS staging system as predictors for cholesteatoma recidivism and postoperative hearing, using a large patient cohort in our tertiary referral center.Method: Two hundred thirty-one patients who underwent surgery for...
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Histology of the Cochlear Outer Sulcus Cells in Normal Human Ears, Presbycusis, and Menière's Disease: Hypothesis: Outer sulcus cell features and distribution are hypothesized to differ throughout regions of the human cochlea and between diseased and normal specimens.Background: Outer sulcus cells play a role in inner ear fluid homeostasis. However, their anatomy and distribution in the human are not well described.Methods: Temporal bone specimens with normal hearing (n = 10), Menière's disease (n = 10),...
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Bleaching efficacy of at home 16% carbamide peroxide. A long‐term clinical follow‐up study: AbstractObjectiveTo assess the whitening efficacy of a 16% carbamide peroxidase (CP) gel after 42 months of clinical follow‐up.Materials and methodsA retrospective clinical study was carried out involving 95 participants. CP 16% was applied for 90 minutes a day for 4 weeks using individualized trays. Tooth color was assessed using spectrophotometry at baseline, 1 week after the end of treatment, and every...
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Supreme™ laryngeal mask airway insertion requires a lower concentration of sevoflurane than ProSeal™ laryngeal mask airway insertion during target-controlled remifentanil infusion: a prospective randomised controlled study: AbstractBackgroundProSeal (PLMA) and Supreme (SLMA) laryngeal mask airways are effective ventilator devices with distinctive designs that may require different anaesthetics for insertion. Sevoflurane induction provides acceptable conditions for laryngeal mask insertion, and remifentanil...
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Patterns of spon1b:GFP expression during early zebrafish brain development: AbstractObjectiveF-spondin is part of a group of evolutionarily conserved extracellular matrix proteins in vertebrates. It is highly expressed in the embryonic floor plate, and it can bind to the ECM and promote neuronal outgrowth. A characterization of F-spondin expression patterns in the adult zebrafish brain was previously reported by our group. However, given its importance during development, we aimed to obtain a detailed...
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Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia: Background and Objectives. Pulmonary arterial hypertension (PAH) pathomechanism involves an increased plasma level of endothelin-1 and a reduced plasma level of prostacyclin and nitric oxide. Whether similar mechanisms prevail in PAH associated with atrial septal defect (ASD) is unclear. This study aimed to...
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Selective Procedural Memory Impairment but Preserved Declarative Memory in Spinocerebellar Ataxia Type 3: AbstractSpinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is an autosomal dominant neurodegenerative disorder that affects mainly the cerebellum and less other brain areas. While the ataxic/motor features of the disease have been well described, the cognitive consequences of the degeneration require additional testing. The aim of this study was to evaluate learning abilities...
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Metabolic regulation of neurodifferentiation in the adult brain: AbstractUnderstanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrated into neuronal circuits requires a complete remodelling of cellular metabolism, including switching the cellular energy source....
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Clinical and Prognostic Implications of P21 (WAF1/CIP1) Expression in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis: Background. Previous studies have demonstrated that P21 (WAF1/CIP1) is a valuable prognostic factor in several malignant tumors. However, it is not known whether P21 can predict the prognosis in patients with esophageal cancer (EC). The aim of this research was to investigate the contribution of P21 expression to the clinicopathological characteristics and...
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Pathogens, Vol. 9, Pages 48: Comparative Pathology of West Nile Virus in Humans and Non-Human Animals: Pathogens, Vol. 9, Pages 48: Comparative Pathology of West Nile Virus in Humans and Non-Human AnimalsPathogens doi: 10.3390/pathogens9010048Authors: Byas Ebel West Nile virus (WNV) continues to be a major cause of human arboviral neuroinvasive disease. Susceptible non-human vertebrates are particularly diverse, ranging from commonly affected birds and horses to less commonly affected species...
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Microscopic investigation of pollen morphology of Brassicaceae from Central Punjab‐Pakistan: First documentation of pollen morphology of Brassicaceae from Central Punjab‐Pakistan. Application of Scanning Electron Microscopy to highlight the pollen morphological features of Brassicaceae. Formulation of taxonomic key to focus variations among studied taxa in terms of pollen morphology. AbstractThe intention of the current study is to provide an account on the palynological features of Brassicaceae...
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Filgotinib, a JAK1 Inhibitor, Modulates Disease-Related Biomarkers in Rheumatoid Arthritis: Results from Two Randomized, Controlled Phase 2b Trials: AbstractIntroductionThe Janus kinase (JAK) inhibitor therapeutic class has shown significant clinical benefit in the treatment of rheumatoid arthritis (RA). We sought to gain insight into the mode of action and immunological effects of filgotinib, a JAK1 selective inhibitor, in active RA by analyzing secreted and cell-based biomarkers key to RA pathophysiology...
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Cellular immune responses in amniotic fluid of women with preterm clinical chorioamnionitis: AbstractObjectivePreterm birth is the leading cause of neonatal morbidity and mortality worldwide. Some preterm births are associated with clinical chorioamnionitis; yet, this condition has been poorly investigated. Herein, we characterized the amniotic fluid cellular immune responses in women with preterm clinical chorioamnionitis.Methods and subjectsAmniotic fluid samples were obtained from women with preterm...
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