Bioethics Genetic parenthood and causation: An objection to Douglas and Devolder's modified direct proportionate genetic descent accountAbstract In a recent publication Tom Douglas and Katrien Devolder have proposed a new account of genetic parenthood, building on the work of Heidi Mertes. Douglas and Devolder's account aims to solve, among other things, the question of who are the genetic parents of an individual created through somatic cell nuclear transfer (i.e. cloning): (a) the nuclear DNA...
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Toxins, Vol. 11, Pages 484: Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug CandidatesToxins, Vol. 11, Pages 484: Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates Toxins doi: 10.3390/toxins11090484 Authors: Gonçalves Lesport Kuylle Stura Ciolek Mourier Servent Bourinet Benoit Gilles Over the two last decades, venom toxins have been explored as alternatives to opioids to treat...
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International Forum of Allergy & Rhinology Impact of margin status on survival after surgery for sinonasal squamous cell carcinomaBackground Sinonasal squamous cell carcinoma (SNSCC) is the most common malignancy of the paranasal sinuses. Surgery is the mainstay of treatment, yet positive surgical margins (PSM) are common and the prognostic impact on overall survival (OS) is mixed. Given the heterogeneity of impact of PSM on OS within the literature, we hypothesized that extent of tumor extirpation...
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Clinical Otolaryngology Recurrence predictability by various staging systems in 283 patients after thyroidectomy and radioactive iodine treated for papillary thyroid carcinomaAbstract The aim of this study was to evaluate the ability of various clincopathologic variables and staging systems to predict recurrence rates of papillary thyroid carcinoma (PTC) treated with total thyroidectomy and followed by biochemical markers and imaging. We conducted a retrospective review of patients that were treated...
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IBA posts revenue increase in 1st half of 2019Proton therapy developer Ion Beam Applications (IBA) posted revenue growth...Read more on AuntMinnieEurope.comRelated Reading: IBA announces ProteusOne contract in Italy IBA posts mixed 2018 financial results IBA secures Belgian ProteusOne contract IBA receives Brazil's OK for proton therapy system Purchase delays affect IBA's 6-month resultsAuntMinnieEurope.com Headlines14hMRI reveals molecular composition of the brainResearchers from Israel have developed...
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Journal of Cosmetic DermatologyAdvances in encapsulated dermal formulations in chemoprevention of melanoma: An overviewAbstract Background The three forms of skin cancer are cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Melanoma skin cancer is an aggressive type and one of the most chemotherapy‐resistant malignancies. Conventional topical products are beset with limitations, leading to lower efficacy. There is a growing need to develop topical formulations encapsulated...
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Fornix-Region Deep Brain Stimulation–Induced Memory Flashbacks in Alzheimer's DiseaseTo the Editor: In a randomized trial involving 42 patients, we assessed deep brain stimulation targeting the fornix to improve cognition in patients with Alzheimer's disease (ClinicalTrials.gov number, NCT01608061; the protocol for the trial is available with the published article). Although the…The New England Journal of Medicine: Search Results in Neurology\NeurosurgerynowMark above section as read British Journal...
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Clinical RheumatologySystemic sclerosis is associated with knee arthroplasty outcomes: a National US studyAbstract Objective To assess whether systemic sclerosis (SSc) is associated with total knee arthroplasty (TKA) outcomes. Methods We used the 1998–2014 US National Inpatient Sample. We conducted multivariable-adjusted logistic regression analyses to examine the association of a diagnosis of SSc with post-TKA in-hospital complications (implant infection, revision,...Latest Results for Clinical...
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pubmed: philosophy for medic...Twelve-Month Outcomes After Transplant of Hepatitis C-Infected Kidneys Into Uninfected Recipients: A Single-Group Trial.Related ArticlesTwelve-Month Outcomes After Transplant of Hepatitis C-Infected Kidneys Into Uninfected Recipients: A Single-Group Trial. Ann Intern Med. 2018 09 04;169(5):273-281 Authors: Reese PP, Abt PL, Blumberg EA, Van Deerlin VM, Bloom RD, Potluri VS, Levine M, Porrett P, Sawinski D, Nazarian SM, Naji A, Hasz R, Suplee L, Trofe-Clark J, Sicilia...
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pubmed: future oncologyImaging-guided precision medicine in glioblastoma patients treated with immune checkpoint modulators: research trend and future directions in the field of imaging biomarkers and artificial intelligence.Related ArticlesImaging-guided precision medicine in glioblastoma patients treated with immune checkpoint modulators: research trend and future directions in the field of imaging biomarkers and artificial intelligence. EJNMMI Res. 2019 Aug 20;9(1):78 Authors: Sinigaglia M, Assi...
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pubmed: esophageal cancerUpper GI biopsies for adenocarcinoma - how many biopsies should endoscopists take?Related ArticlesUpper GI biopsies for adenocarcinoma - how many biopsies should endoscopists take? Histopathology. 2019 May;74(6):959-963 Authors: Kaye P, Lindsay D, Madhusudan S, Vohra R, Catton J, Platt C, Ragunath K Abstract AIMS: There is evidence that four or five gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken...
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pubmed: autophagyHydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response.Related ArticlesHydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response. Int J Mol Med. 2019 Aug 05;: Authors: Sun T, Chen Q, Zhu SY, Wu Q, Liao CR, Wang Z, Wu XH, Wu HT, Chen JT Abstract Advanced oxidation protein products (AOPPs) can trigger NADPH...
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pubmed: "microsurgery"[jour]Penoscrotal reconstruction with superficial circumflex iliac artery perforator propeller flap.Penoscrotal reconstruction with superficial circumflex iliac artery perforator propeller flap. Microsurgery. 2019 Aug 21;: Authors: Han HH, Ahn MR, Lee JH Abstract BACKGROUND: Successful penoscrotal reconstruction requires proper resurfacing of the defect and maintenance of the original shape of the penis and scrotum. We examined the feasibility of using the superficial circumflex...
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pubmed pediatrics [jour] An End in Sight: Shorter Duration of Parenteral Antibiotics in Neonates....
pubmed pediatrics [jour]An End in Sight: Shorter Duration of Parenteral Antibiotics in Neonates.Related ArticlesAn End in Sight: Shorter Duration of Parenteral Antibiotics in Neonates. Pediatrics. 2019 Aug 20;: Authors: Leva NV, Copp HL PMID: 31431481 [PubMed - as supplied by publisher]pubmed pediatrics [jour]18hParenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections.Related ArticlesParenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary...
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Curr Opin Otolaryngol Head Neck Surg [jour]Cerebrospinal fluid physiology.Cerebrospinal fluid physiology. Curr Opin Otolaryngol Head Neck Surg. 2019 Aug 19;: Authors: Samy RN PMID: 31433333 [PubMed - as supplied by publisher]NCBI db=pubmed; Term= Curr Opin Otolaryngol Head Neck Surg [jour]18hPhysiology of cerebrospinal fluid circulation.Physiology of cerebrospinal fluid circulation. Curr Opin Otolaryngol Head Neck Surg. 2019 Aug 19;: Authors: Shapey J, Toma A, Saeed SR Abstract PURPOSE OF REVIEW:...
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Head and Neck Sex difference in IgE sensitization associated with alcohol consumption in the general population.Related ArticlesSex difference in IgE sensitization associated with alcohol consumption in the general population. Sci Rep. 2019 Aug 20;9(1):12131 Authors: Roh D, Lee DH, Lee SK, Kim SW, Kim SW, Cho JH, Kim BG, Shin JH Abstract The association of alcohol consumption and immunoglobulin E (IgE) sensitization is debated. Few population-based studies have investigated whether such associations...
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Head and Neck Health-Related Quality of Life, Satisfaction with Care, and Cosmetic Results in Relation to Treatment among Patients with Keratinocyte Cancer in the Head and Neck Area: Results from the PROFILES Registry.Health-Related Quality of Life, Satisfaction with Care, and Cosmetic Results in Relation to Treatment among Patients with Keratinocyte Cancer in the Head and Neck Area: Results from the PROFILES Registry. Dermatology. 2019 Aug 21;:1-10 Authors: Arts LPJ, Waalboer-Spuij R, de Roos...
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MedWorm ENT & OMF News Medical News Today: Earwax color chart: What to knowThe ears are self-cleaning and produce earwax to push out dirt and debris. In this article, learn what different ear wax colors and textures indicate, as well as how to safely clean the ears. (Source: Health News from Medical News Today)MedWorm ENT & OMF News19hMark above section as read MedWorm ENT & OMF Research[Pathophysiology of obstructive sleep apnea].Authors: Heiser C, Eckert D Abstract The prevalence...
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MedWorm Cancer & Oncology Research , Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypesWe report the separation of two small EV sub-populations from a metastatic breast cancer cell line, with biochemical features consistent with different sub-cellular origins. These EV sub-types use different mechanisms of miRNA sorting (selective and non-selective), suggesting that sorting occurs via fundamentally distinct processes, possibly dependent on EV origin....
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MedWorm Cancer & Oncology Research MicroRNA ‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer.MicroRNA‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer. Mol Med Rep. 2019 Jul 31;: Authors: Liu L, Wang W, Gao S, Wang X Abstract The abnormal expression of microRNAs (miRNAs/miRs) has a critical function in the formation and progression...
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MedWorm Cancer & Oncology Clinical Trials , Circulating Tumor Cell Detection in Patients With Luminal A Breast CancerCondition: Breast Neoplasms Interventions: Procedure: PET-CT examination; Procedure: Peripheral blood detection Sponsor: Shengjing Hospital Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Cancer & Oncology Clinical Trials4hIntra-Peritoneal Local Anaesthetics in Ovarian CancerCondition: Ovarian Cancer Interventions: Drug: Ropivacaine; Drug: Saline Solution...
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MedWorm Allergy & Immunology AstraZeneca Imfinzi Combination Fails Advanced Lung Cancer Study A combination of AstraZeneca's lung cancer drug Imfinzi and an experimental treatment failed to extend the lives of patients with advanced non-small cell lung cancer (NSCLC) and high levels of gene mutations, the drugmaker said on Wednesday.Reuters Health Information (Source: Medscape Allergy Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on...
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Molecular and clinicopathological analyses of esophageal carcinosarcoma with special reference to...
Molecular and clinicopathological analyses of esophageal carcinosarcoma with special reference to morphological changeAbstract The molecular pathogenesis of esophageal carcinosarcoma (ECS) has not been fully investigated. This study includes 16 consequent cases of surgically resected ECS. Genetic alterations were independently examined for carcinoma in situ, carcinomatous, and sarcomatous areas. Six cases were analyzed by next-generation sequencing, and the remaining cases were analyzed by Sanger...
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Cancers, Vol. 11, Pages 1232: L19-IL2 Immunocytokine in Combination with the Anti-Syndecan-1 46F2SIP Antibody Format: A New Targeted Treatment Approach in an Ovarian Carcinoma ModelCancers, Vol. 11, Pages 1232: L19-IL2 Immunocytokine in Combination with the Anti-Syndecan-1 46F2SIP Antibody Format: A New Targeted Treatment Approach in an Ovarian Carcinoma Model Cancers doi: 10.3390/cancers11091232 Authors: Paola Orecchia Enrica Balza Gabriella Pietra Romana Conte Nicolò Bizzarri Simone Ferrero Maria...
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Outcomes associated with peripherally inserted central catheters in hospitalised children: a retrospective 7-year single-centre experienceObjectivesThe use of peripherally inserted central catheters (PICCs) are an integral part of caring for hospitalised children. We sought to estimate the incidence of and identify the risk factors for complications associated with PICCs in an advanced registered nurse practitioners (ARNP)-driven programme. DesignRetrospective cohort study. SettingSingle-centre,...
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A comparison of different vaccination schemes used in sheep combining inactivated bluetongue vaccines against serotypes 4 and 8.Authors: Hilke J, Strobel H, Woelke S, Stoeter M, Voigt K, Grimm L, Meilwes J, Punsmann T, Blaha I, Salditt A, Rohn K, Bastian M, Ganter M Abstract Eight different vaccination schemes using four commercially available inactivated Bluetongue vaccines against serotypes 4 and 8 in three different combinations (setting 1-3) were tested under field conditions for their ability...
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GSE119042 Thermo Fisher Scientific OncoScan expression array data for undifferentiated uterine sarcomas (CNV)Series Type : Genome variation profiling by arrayOrganism : Homo sapiensThermo Fisher Scientific OncoScan expression array data for undifferentiated uterine sarcomaGEO series published today2hGSE136205 H3K27me3 ChIP-Seq analysis of ErbB2-driven mouse mammary tumour cells treated with GSK-126Contributors : Alison Hirukawa ; William J MullerSeries Type : Genome binding/occupancy profiling by...
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Case 26-2019: A 27-Year-Old Woman with Opioid Use Disorder and Suicidal IdeationPresentation of Case. Dr. Andrew Cruz (Psychiatry): A 27-year-old woman was evaluated at this hospital because of a suicide attempt. Approximately 3 months before admission, the patient became homeless and was staying intermittently with friends. Two months before admission, she began to ingest…The New England Journal of Medicine Search Results in Clinical Cases4mWhite House Asbestos Risk Forces Top Staff RelocationThe...
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Nutrients, Vol. 11, Pages 1992: Systematic Review and Meta-Analysis: Accuracy of Both Gamma Delta+ Intraepithelial Lymphocytes and Coeliac Lymphogram Evaluated by Flow Cytometry for Coeliac Disease DiagnosisNutrients, Vol. 11, Pages 1992: Systematic Review and Meta-Analysis: Accuracy of Both Gamma Delta+ Intraepithelial Lymphocytes and Coeliac Lymphogram Evaluated by Flow Cytometry for Coeliac Disease Diagnosis Nutrients doi: 10.3390/nu11091992 Authors: Fernando Fernández-Bañares Ana Carrasco Albert...
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Adjuvant therapy with Astragalus membranaceus for post-stroke fatigue: a systematic reviewAbstract Post-stroke fatigue (PSF) is a common symptom after stroke and interferes with the rehabilitation. There are limited pharmacological therapies for managing PSF. Astragalus membranaceus (Huangqi) is a frequently used Chinese herbal medicine (CHM) in the treatment of fatigue in China. The aim of this review was to summarize the efficacy of adjuvant therapy with CHM Huangqi (CHM-HQ) in managing fatigue...
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American Journal of Otolaryngology Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survivalPublication date: Available online 21 August 2019Source: American Journal of OtolaryngologyAuthor(s): Avigeet Gupta, Sina Koochakzadeh, David M. Neskey, Shaun A. Nguyen, Eric J. LentschAbstractPurposeIdentify variables that are independent predictors of survival in carcinoma ex pleomorphic adenoma (CXPA) of the major salivary glands using a population-based database...
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*Journal* of *Medical Internet Research* Comparing Characteristics of Patients Who Connect Their iPhones to an Electronic Health Records System Versus Patients Who Connect Without Personal Devices: Cohort Study*Journal* of *Medical Internet Research*15hMark above section as read BioMed Research InternationalCorrigendum to "Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury"BioMed Research International17hRetracted: Treatment of Acute Pulmonary...
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The New England Journal of Medicine: Neurology\Neurosurgery Fornix-Region Deep Brain Stimulation–Induced Memory Flashbacks in Alzheimer's DiseaseTo the Editor: In a randomized trial involving 42 patients, we assessed deep brain stimulation targeting the fornix to improve cognition in patients with Alzheimer's disease (ClinicalTrials.gov number, NCT01608061; the protocol for the trial is available with the published article). Although the…The New England Journal of Medicine: Neurology\Neurosurgery8hMark...
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Environmental Justice - Open Defecation in the United States: Perspectives from the StreetsEnvironmental Justice, Ahead of Print.Environmental Justice - Table of Contents12hMark above section as read Environmental Toxicology and ChemistryMetal Exposure Risk Assessment for Tree Sparrows at Different Life Stages via Diet from a Polluted Area in Northwestern ChinaAbstract To estimate the risks of metal (Cu, Zn, Pb and Cd) exposure of tree sparrows through food at different life stages (including nestling,...
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British Journal of Dermatology The basket‐weave pattern is present in the skin for a reasonBritish Journal of Dermatology21hMark above section as read Journal of Investigative DermatologyLate-Breaking Abstracts Title PageLate-Breaking AbstractsJournal of Investigative Dermatology8hLB1057 Ultraviolet B light induces rapid changes in gene expression as detected by non-invasive, adhesive skin biopsiesThe purpose of this study is to determine changes in skin gene expression following exposure to ultraviolet...
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BMJ Case Reports ,An unusual cause of paraesthesia in a neo-adjuvant gastro-oesophageal cancerThere is ongoing debate about the best neo-adjuvant strategy for localised resectable oesophageal cancer, however chemotherapy is often employed. Both oesophageal cancer and cisplatin carry an increased risk of thrombosis. Here, we look at an unusual finding in a previously fit woman who presented following neo-adjuvant chemotherapy for resectable oesophageal cancer with increasing difficulty in walking...
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Journal of Experimental & Clinical Cancer Research - S1PR1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating STAT3 pathwayEsophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, which lacks effective biomarkers for prognosis. Therefore, it is urgent to explore new potential molecular markers to disc...Journal of Experimental & Clinical Cancer Research - Latest Articles2hInhibition of COX-2, mPGES-1 and CYP4A...
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Annals of Diagnostic Pathology Goblet cell tumors of the appendix: A reviewPublication date: Available online 21 August 2019Source: Annals of Diagnostic PathologyAuthor(s): Sara A.J. Sinno, Nawaf M.H. JurdiAbstractGoblet cell tumors are rare tumors of the appendix that exhibit both neuroendocrine and mucinous differentiation. This dual differentiation has led to a controversy regarding the proper classification of these neoplasms as to whether they should be considered neuroendocrine tumors or...
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Annals of Clinical Microbiology and Antimicrobials - A systematic review of the impact of antifungal stewardship interventions in the United StatesAntimicrobial resistance is a widely recognized public health threat, and stewardship interventions to combat this problem are well described. Less is known about antifungal stewardship (AFS) initiatives and t...Annals of Clinical Microbiology and Antimicrobials - Latest Articles4hMark above section as read AntibioticsAntibiotics, Vol. 8, Pages 126: The...
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Anaesthesia Good intra‐operative anaesthesia is more than an 'airway, breathing, circulation, drugs with a three, two and a one'Anaesthesia21hImproving early warning scores – more data, better validation, the same responseAnaesthesia21hMark above section as read Latest Results for Der AnaesthesistBeatmung und SauerstofftherapieLatest Results for Der Anaesthesist16hFokus NephrologieLatest Results for Der Anaesthesist16hFokus NeurochirurgieLatest Results for Der Anaesthesist16hMark above section as...
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Journal of AnatomyIssue InformationJournal of Anatomy21hHuman cerebral cortex developmentJournal of Anatomy21hSomato‐dendritic morphology and axon origin site specify von Economo neurons as a subclass of modified pyramidal neurons in the human anterior cingulate cortexVon Economo neurons (VENs) in the human anterior cingulate cortex have specific somato‐dendritic morphology on Golgi staining. The most notable morphological feature for their reliable identification is the extremely distant position...
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BMC Anesthesiology - A comparison between the Disposcope endoscope and fibreoptic bronchoscope for nasotracheal intubation: a randomized controlled trialNasotracheal intubation (NTI) is frequently performed for oral and maxillofacial surgeries. This study evaluated whether NTI is easier when guided by Disposcope endoscopy or fibreoptic bronchoscopy.BMC Anesthesiology - Latest Articles1hEpidural analgesia and avoidance of blood transfusion are associated with reduced mortality in patients with postoperative...
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Allergology International Mesenchymal stem cells in allergic diseases: Current status Publication...
Allergology International Mesenchymal stem cells in allergic diseases: Current statusPublication date: Available online 21 August 2019Source: Allergology InternationalAuthor(s): He Li, Yunzhe Tian, Lihui Xie, Xiuxing Liu, Zhaohao Huang, Wenru SuAbstractAllergic diseases, which include asthma, allergic skin diseases, allergic rhinitis and allergic conjunctivitis, have already garnered worldwide public health attention over recent decades. Mesenchymal stem cells (MSCs) have gradually emerged as a...
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American Journal of Clinical Oncology - Oncologic Accuracy of Image-guided Percutaneous Core-Needle Biopsy of Peripheral Nerve Sheath Tumors at a High-volume Sarcoma CenterObjectives: Peripheral nerve sheath tumors (PNSTs) are clinically heterogenous, comprising benign (BPNST) and malignant (MPNST) variants. BPNSTs can be managed with nerve-sparing excision or observation. MPNSTs require radical resection and multidisciplinary oncologic management (1, 15). Image-guided core-needle biopsy (IGCNBx)...
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GSK-3β Inhibitor Induces Expression of the TLR4/MyD88/NF-κB Signaling Pathway to Protect Against Renal Ischemia-Reperfusion Injury During Rat Kidney TransplantationAbstract Ischemia-reperfusion injury (IRI) is an inevitable consequence of kidney transplantation (KT). The aim of our study was to investigate the protective effect of a glycogen synthase kinase 3β (GSK-3β) inhibitor against cold IRI in a rat renal transplantation (RT) model and a rat cold-IRI model through the toll-like receptor 4 (TLR4)/myeloid...
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Nutrients, Vol. 11, Pages 1989: Association between Ready-to-Eat Cereal Consumption and Nutrient Intake, Nutritional Adequacy, and Diet Quality among Infants, Toddlers, and Children in the National Health and Nutrition Examination Survey 2015–2016Nutrients, Vol. 11, Pages 1989: Association between Ready-to-Eat Cereal Consumption and Nutrient Intake, Nutritional Adequacy, and Diet Quality among Infants, Toddlers, and Children in the National Health and Nutrition Examination Survey 2015–2016 Nutrients...
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Journal of Functional Morphology and Kinesiology JFMK, Vol. 4, Pages 61: Eccentric Overload Flywheel Training in Older AdultsJFMK, Vol. 4, Pages 61: Eccentric Overload Flywheel Training in Older Adults Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk4030061 Authors: Kelsi Kowalchuk Scotty Butcher Age-related reductions in muscle strength and muscle power can have significant adverse effects on functional performance in older adults. Exercise training has been shown to be a potent...
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Antibiotics, Vol. 8, Pages 126: The Perfect Bacteriophage for Therapeutic Applications—A Quick GuideAntibiotics, Vol. 8, Pages 126: The Perfect Bacteriophage for Therapeutic Applications—A Quick Guide Antibiotics doi: 10.3390/antibiotics8030126 Authors: Lucía Fernández Diana Gutiérrez Pilar García Ana Rodríguez The alarming spread of multiresistant infections has kick-started the quest for alternative antimicrobials. In a way, given the steady increase in untreatable infectious diseases, success...
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SAGE Publications Ltd: Journal of International Medical Research: Table of Contents, Gut microbiota: an overlooked factor that plays a significant role in osteoporosisJournal of International Medical Research, Ahead of Print.SAGE Publications Ltd: Journal of International Medical Research: Table of ContentsThu Aug 22, 2019 13:20Bacteroides fragilis sacral spondylodiscitis and epidural abscess after sacrocolpopexy: a case report and literature reviewJournal of International Medical Research, Ahead...
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