Development of an extensive assessment list for knee osteoarthritis based on the International Classification of Functioning, Disability and Health: a Delphi studyThe objective of this study was to develop an extensive assessment list for individuals with knee osteoarthritis based on the International Classification of Functioning, Disability and Health (ICF) osteoarthritis comprehensive Core Set. Ten experienced physical therapists including five lecturers and five clinicians were purposively nominated...
Gadolinium Deposition in the Brain in a Large Animal Model: Comparison of Linear and Macrocyclic Gadolinium-Based Contrast AgentsObjective Recent studies reported a signal intensity increase in the deep cerebellar nuclei (DCN) on magnetic resonance images caused by gadolinium deposition after the injection of gadolinium-based contrast agents (GBCAs). There is an ongoing debate if the propensity of a GBCA to deposit gadolinium is primarily determined by its class as either linear or macrocyclic. In...
https://journals.lww.com/investigativeradiology/toc/9000/00000Back to the Future: Lipiodol in Lymphography—From Diagnostics to TheranosticsLipiodol is an iodinated poppy seed oil first synthesized in 1901. Originally developed for therapeutic purposes, it has mainly become a diagnostic contrast medium since the 1920s. At the end of the 20th century, Lipiodol underwent a transition back to a therapeutic agent, as exemplified by its increasing use in lymphangiography and lymphatic interventions. Nowadays,...
Implementation of a Modified Enhanced Recovery Protocol in Cleft Palate RepairsAims: Enhanced Recovery after Surgery (ERAS) protocols have been shown to improve patient outcomes in numerous adult surgical populations, but there are few known standards for their use in pediatric patients. To assess the effectiveness in pediatric craniofacial surgery, we present our results following the application of a modified ERAS protocol for patients undergoing primary palatoplasty. Methods: A modified ERAS program...
Effect of cuff inflation technique in video laryngoscopic assisted nasal intubation in oral cancer surgeriesKinna G Shah, Bhavna C Shah, Mehul PatelMedical Journal of Dr. D.Y. Patil Vidyapeeth 2019 12(4):340-344Introduction: TA scope is an indirect optical video laryngoscope (VL) which provides a better glottic view without manipulating all three airway axis. Cuff inflation in nasal tube (NT) makes tube midline and good alignment with glottic opening. Aim: This study aims to evaluate the success...
A journey of a thousand miles begins with a single step…Miles to GO!Amitav BanerjeeMedical Journal of Dr. D.Y. Patil Vidyapeeth 2019 12(4):289-291Moving from the old monoaminergic theory toward the emerging hypothesis in the rational design of rapid-onset novel antidepressantsOlumuyiwa John FasipeMedical Journal of Dr. D.Y. Patil Vidyapeeth 2019 12(4):292-315Antidepressants can be classified into 13 different classes based on their pharmacological mechanisms of action. As of this present moment,...
Simulation-Based Training is Associated with Lower Risk-Adjusted Mortality in ACS Pediatric TQIP CentersBackground Although use of simulation-based team training for pediatric trauma resuscitation has increased, its impact on patient outcomes has not yet been shown. The purpose of this study was to determine the association between simulation use and patient outcomes. Methods Trauma centers that participate in the American College of Surgeons (ACS) Pediatric Trauma Quality Improvement Program (TQIP)...
RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy ResistancePublication date: Available online 27 June 2019Source: Cancer CellAuthor(s): Daniël A. Lionarons, David C. Hancock, Sareena Rana, Philip East, Christopher Moore, Miguel M. Murillo, Joana Carvalho, Bradley Spencer-Dene, Eleanor Herbert, Gordon Stamp, Djamil Damry, Dinis P. Calado, Ian Rosewell, Ralph Fritsch, Richard R. Neubig, Miriam Molina-Arcas, Julian DownwardSummaryRAC1 P29...
Uptake of 18F-Fluciclovine in Paget DiseaseSince its recent approval by the United States Food and Drug Administration, fluciclovine PET-CT has gained widespread use for imaging of recurrent prostate cancer patients. As an amino acid–based radiotracer transported by LAT-1 and ASCT-2 transporters, fluciclovine exploits the up-regulation of amino acid transporters in malignant cells. We present a rare case of fluciclovine uptake in Paget disease in a 58-year-old man with suspected recurrent prostate...
American Journal of Otolaryngology,New articles available on ScienceDirectNew Articles in Press, 08 JulyMandibular rescue: Application of the ALT fascia free flap to arrest osteoradionecrosis of the mandible Available Online 08 July 2019Timothy Haffey, Ryan Winters, Rhorie Kerr, Michael Fritz select article Mandibular rescue: Application of the ALT fascia free flap to arrest osteoradionecrosis of the mandibleResearch articleAbstract onlyMandibular rescue: Application of the ALT fascia free flap to...
Fortschritte in der neoadjuvanten Therapie bei lokal fortgeschrittenem PankreaskarzinomLaparoskopische vs. offene Appendektomie bei vermuteter Appendizitis in der SchwangerschaftLangzeitergebnisse nach Adrenalektomie beim CONN-Syndrom mit Schichtbilddiagnostik und Lateralisation durch StufenkatheterAkute Cholezystitis bei HochrisikopatientenPräoperative KonditionierungRisikofaktoren und assoziierte Komplikationen bei Vorhofflimmern nach ÖsophagektomiePräoperative Konditionierung im Alter – GerontochirurgieZusammenfassungDie...
The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive functionAbstractObjectiveDisturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer's disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.MethodWe performed polysomnography (PSG)...
Overall survival and progression-free survival in patients with primary brain tumors after treatment: is the outcome of [ 18 F] FDOPA PET a prognostic factor in these patients?AbstractAimTo investigate the progression-free survival (PFS) and the overall survival (OS) in a population affected by primary brain tumors (PBT) evaluated by [18F]-l-dihydroxyphenylalanine ([18F] FDOPA) positron emission tomography/computed tomography (PET/CT).Materials and methods133 subjects with PBT (65 women and 68 men,...
Diagnostic performance of 18 F-FDG PET-CT for large vessel involvement assessment in patients with suspected giant cell arteritis and negative temporal artery biopsyAbstractObjectiveThe purpose of our study was to assess the diagnostic performance of 18F-FDG PET-CT for large vessel involvement in patients with suspected giant cells arteritis (GCA) and a negative temporal artery biopsy (TAB).MethodsWe conducted a retrospective study in a cohort of patients with suspected GCA and negative TAB who underwent...
A novel biomarker, active whole skeletal total lesion glycolysis (WS-TLG), as a quantitative method to measure bone metastatic activity in breast cancer patientsAbstractObjectiveThere is no good response evaluation method for skeletal metastasis. We aimed to develop a novel quantitative method to evaluate the response of skeletal metastasis, especially lytic lesions, for treatment.MethodsA method to measure active bone metastatic burden quantitatively using F-18 fluorodeoxyglucose positron emission...
The difference of risk factors predicting cardiac events in patients with chronic kidney disease between with and without diabetesAbstractObjectiveChronic kidney disease (CKD) and diabetes are both associated with cardiovascular disease, but the effects of diabetes in patients with CKD remain unknown. This study aimed to compare the risk factors of cardiac events between patients with CKD accompanied and not by diabetes using myocardial perfusion imaging.MethodsWe initially classified 529 patients...
Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in mantle cell lymphomaAbstractObjectiveMantle cell lymphoma (MCL) is an aggressive lymphoma sub-type with poor prognosis and high 18F-FDG avidity at PET/CT; nowadays, no validated criteria for PET/CT in treatment response evaluation and prediction of outcome are present. The aim of study was to investigate whether the metabolic PET/CT features may predict treatment evaluation and prognosis in MCL.MethodsWe retrospectively enrolled 87...
Comparison between the different doses of radioactive iodine ablation prescribed in patients with intermediate-to-high-risk differentiated thyroid cancerAbstractObjectiveThis study aimed to compare the clinical outcomes of patients who received radioactive iodine (RAI) ablation after undergoing thyroidectomy for intermediate-to-high-risk differentiated thyroid carcinoma (DTC) according to the American Thyroid Association (ATA) criteria.MethodsWe retrospectively examined patients who underwent RAI...
The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive functionAbstractObjectiveDisturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer's disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.MethodWe performed polysomnography (PSG)...
Cytogenetic profile of a representative cohort of young adults with de novo acute myéloblastic leukaemia in MoroccoPublication date: October 2019Source: Cancer Genetics, Volume 238Author(s): Nisrine Khoubila, Mounia Bendari, Nezha Hda, Mouna Lamchahab, Meryem Qachouh, Mohamed Rachid, Asmaa QuessarAbstractBackgroundWe analyzed the cytogenetic characteristics of a representative population of young adults with de novo acute myéloblastic leukemia (AML) treated in a single center institution.MethodsPatients...
How to Choose a Mouse Model of Breast Cancer, a Genomic PerspectiveAbstractHuman breast cancer is a heterogeneous disease with numerous subtypes that have been defined through immunohistological, histological, and gene expression patterns. The diversity of breast cancer has made the study of its various underlying causes complex. To facilitate the examination of particular facets of breast cancer, mouse models have been generated, ranging from carcinogen induced models to genetically engineered mice....
Rosai‐Dorfman disease successfully treated with thalidomide: A case reportMohammad Shahidi‐Dadras Behnaz Hamedani Nasim Niknezhad Nasim GhilizadehFirst published: 22 June 2019 https://doi.org/10.1111/dth.13005Read the full textePDFPDFTOOLS SHAREAbstractRosai‐Dorfman disease (RDD) is a rare disease which characterized by proliferation and overproduction of histiocytes in the lymph nodes appearing as lymphadenopathy, however, it may also occur in extranodal sites. The occurrence of unusual manifestations...
The Benefit of a Ceramide‐Linoleic Acid‐Containing Moisturizer as an Adjunctive Therapy for a Set of Xerotic DermatosesQi Yang M.D. Min Liu M.D. Xia Li M.D. Jie Zheng M.D/Ph.D.First published: 05 July 2019 https://doi.org/10.1111/dth.13017ePDFPDFTOOLS SHAREABSTRACTAtopic dermatitis (AD), chronic eczema and pruritus hiemalis are a set of prevalent chronic xerotic skin disorders which share clinical features such as dryness, scales and pruritus. A ceramide deficiency and defective epidermal functions...
Brain Tumor-Enhancement Visualization and Morphometric Assessment: A Comparison of MPRAGE, SPACE, and VIBE MRI TechniquesL. Danieli, G.C. Riccitelli, D. Distefano, E. Prodi, E. Ventura, A. Cianfoni, A. Kaelin-Lang, M. Reinert and E. PravatàAmerican Journal of Neuroradiology July 2019, 40 (7) 1140-1148; DOI: https://doi.org/10.3174/ajnr.A6096ArticleFigures & DataSupplementalInfo & MetricsReferences PDFThis article requires a subscription to view the full text. If you have a subscription you...
What's wrong with truth-conditional accounts of slursAbstractThe aim of this paper is to provide arguments based on linguistic evidence that discard a truth-conditional analysis of slurs (TCA) and pave the way for more promising approaches. We consider Hom and May's version of TCA, according to which the derogatory content of slurs is part of their truth-conditional meaning such that, when slurs are embedded under semantic operators such as negation, there is no derogatory content that projects out...
RESEARCHAwareness and utilization of female condoms among street youths in Ibadan, an urban setting in South-West NigeriaObioma Chukwudi Uchendu et al.Condoms are the only method available technologically that prevents against several STIs including HIV and unwanted pregnancies. It has been found to be very effective compared to other forms of contraception. Female condom awareness and use have been poorly documented in sub-Saharan region especially among street youths. READ MOREHealthcare seeking...
Cold water immersion test (10 °C, 10 min) for diagnosing vibration-induced white finger among a group of polishers in a subtropical environmentAbstractObjectiveThis study aimed to investigate whether the finger skin temperature (FST) after cold provocation (10 °C, 10 min) is as a useful indicator for assisting in the diagnosis of vibration-induced white finger (VWF) in a group of polishers in a subtropical environment.MethodNinety male vibration-exposed metal polishers (30 patients and 60 controls)...
Shift work and mental health: a systematic review and meta-analysisAbstractBackgroundShift work is common. However, research findings are mixed regarding the impact of shift work on mental health. This systematic review sought to provide a comprehensive summary of existing research examining the association between different types of shift work and mental health. The review included large-scale, non-occupation-specific research.MethodsFour electronic databases PubMed, PsycINFO, Web of Science and...
Burnout symptomatology and social support at work independent of the private sphere: a population-based study of French teachersAbstractPurposeTo investigate the relationship between social support at work and burnout among teachers, independent of the teachers' private social and environmental context.MethodsIn the 2013 "Teachers' Quality of Life" population-based study (France, n = 2653), burnout symptomatology was assessed using the Maslach Burnout Inventory. The score for each dimension (emotional...
Workplace violence and development of burnout symptoms: a prospective cohort study on 1823 social educatorsAbstractPurposeBurnout and workplace violence (WPV) have been associated in cross-sectional studies, but longitudinal studies with solid methods and adequate sample sizes are lacking. This study investigates whether WPV increases burnout symptoms during a 12-month period.MethodsQuestionnaire data were collected on 1823 social educators at baseline and 12-month follow-up, coupled with additionally...
Short rest between shifts (quick returns) and night work is associated with work-related accidentsAbstractPurposeThe aim of this study was to examine whether less than 11 h between shifts (i.e., quick returns, QRs) and night shifts is associated with self-reported work-related accidents, near accidents or dozing off at work in a sample of nurses.MethodsThe study was based on cross-sectional data from 1784 nurses (response rate = 60%; mean age = 40.1 years, SD = 8.4; 91% female). Negative binomial...
Common mental disorders through the eyes of German employees: attributed relevance of work-related causes and prevention measures assessed by a standardised surveyAbstractPurposeCommon mental disorders (CMDs) are becoming increasingly relevant in the working world. Numbers of risk factors have been confirmed by mostly correlative cross-sectional studies. Comprehensive and effective prevention is urgently needed. There is little knowledge about employees' own perceptions on causes of CMDs and prevention...
Common mental disorders through the eyes of German employees: attributed relevance of work-related causes and prevention measures assessed by a standardised surveyAbstractPurposeCommon mental disorders (CMDs) are becoming increasingly relevant in the working world. Numbers of risk factors have been confirmed by mostly correlative cross-sectional studies. Comprehensive and effective prevention is urgently needed. There is little knowledge about employees' own perceptions on causes of CMDs and prevention...
Induction therapy in elderly kidney transplant recipients with low immunological riskBackground. In nonimmunized patients, similar rejection rates are observed for patients who have undergone Thymoglobulin (ATG) or Basiliximab (BSX) therapy. Whilst ATG may improve Delayed Graft Function (DGF), it may also be associated with higher infection rates and malignancy risk. We compared survival and clinical outcomes in elderly recipients with low immunological risk according to their induction therapy....
: A Case ReportHyperthyroidism during pregnancy is a relatively rare event, but poor control of hyperthyroidism during pregnancy is associated with a host of issues. These include intrauterine fetal demise, hypertensive disorders of pregnancy, preterm delivery, low birth weight, intrauterine growth restriction, and maternal congestive heart failure. One of the most feared sequelae of hyperthyroidism is thyroid storm, which has a mortality rate >10%. Patients who develop thyroid storm present several...
Prolapse of Aortic Right Coronary Cusp Causing Right Ventricular Outflow Tract Obstruction in a Child With Large Ventricular Septal DefectNo abstract availableDelayed Neuromuscular Blockade Reversal With Sugammadex After Vecuronium, Desflurane, and Magnesium Administration: A Case ReportA variety of factors are known to prolong neuromuscular blockade, including several medications commonly used in anesthetic practice. We present a patient who underwent general anesthesia using desflurane, vecuronium,...
Selenium does not affect radiosensitivity of breast cancer cell lines,AbstractSupplementation with the antioxidant selenium is frequently performed in breast cancer patients to protect the normal tissue from radiation-induced side effects. However, concerns exist whether selenium also protects tumor cells from radiation-induced cell kill and thereby reduces the efficacy of radiotherapy. In this work, the effect of selenium administration on the radiosensitivity of breast cancer cells was evaluated...
Selenium does not affect radiosensitivity of breast cancer cell linesAbstractSupplementation with the antioxidant selenium is frequently performed in breast cancer patients to protect the normal tissue from radiation-induced side effects. However, concerns exist whether selenium also protects tumor cells from radiation-induced cell kill and thereby reduces the efficacy of radiotherapy. In this work, the effect of selenium administration on the radiosensitivity of breast cancer cells was evaluated...
Inclusive malt barley business and household food security in Lay Gayint district of northern EthiopiaAbstractFood security has become a major problem in Ethiopia. To reverse the situation, inclusive businesses, such as malt barley production, are being promoted. However, the determinants of inclusion in the malt barley industry and the food security impacts of inclusion have not been studied systematically. Thus, the objectives of the present research were twofold, namely to investigate the reason...
Taku Fujimura Takahiro Okabe Kayo Tanita Yota Sato Lyu Chunbing Yumi Kambayashi Shigenao Maruyama Setsuya AibaFirst published: 02 July 2019 https://doi.org/10.1111/exd.13997This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/exd.13997ePDFPDFTOOLS SHAREAbstractThe...
Megan A. Palmer Liam Blakeborough Matthew Harries Iain S. HaslamFirst published: 01 July 2019 https://doi.org/10.1111/exd.13993This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/exd.13993ePDFPDFTOOLS SHAREAbstractLipids and lipid metabolism are critical factors...
Why does sweat lead to the development of itch in atopic dermatitis?Hiroyuki Murota Kosuke Yamaga Emi Ono Naoya Murayama Hiroo Yokozeki Ichiro KatayamaFirst published: 01 June 2019https://doi.org/10.1111/exd.13981Sweating plays an important role in maintaining temperature homeostasis in humans. However, under certain circumstances, sweat can cause itching. For example, when excessive sweat accumulates on the skin surface for a long period, miliaria can develop and cause itching. Subjects with dermatoses,...
Fitness, Pathology, or Both?Steele, Ian H. MD; Pope, Harrison G. Jr. MD; Kanayama, Gen MD, PhDHarvard Review of Psychiatry: July/August 2019 - Volume 27 - Issue 4 - p 233–240doi: 10.1097/HRP.0000000000000211ReviewsBUYSDCAbstractAuthor InformationArticle MetricsThe sport of competitive bodybuilding requires an intense regimen of weightlifting and dieting, often aided with muscle-building or fat-burning drugs, and culminating in an on-stage posing competition. Despite these rigorous demands, competitive...
Etiology, Taxonomy, and Response to Electroconvulsive TherapyMartinez, Audrey MD; Spearman, E. Vanessa MD; Parker, Carmen Black MD; Rosenquist, Peter B. MD; McCall, William V. MD, MSSection Editor(s): Givon, Lior MD, PhD; EditorHarvard Review of Psychiatry: July/August 2019 - Volume 27 - Issue 4 - p 254–259doi: 10.1097/HRP.0000000000000229
Suicidal Risk Following Hospital Discharge: A ReviewLearning objectives After participating in this activity, learners should be better able to: • Evaluate risk of suicide and suicide attempts following psychiatric hospitalization • Assess the relationship between suicide attempts and completed suicides Background Suicidal risks among psychiatric patients appear to be especially high soon after hospitalization. Given the importance of such outcomes, and the lack of recent reviews of post-discharge...
Editorial introductionsNo abstract availableImpact of obesity on male and female reproductive outcomesPurpose of review The association between obesity and infertility has gained increasing provider and public awareness. The purpose of this review is to outline the recent research into the pathophysiology regarding obesity and its impact of reproductive function in both women and men. Recent findings A BMI more than 25 has a detrimental impact on the hypothalamus-pituitary-gonadal (HPG) axis in both...
Editorial introductionsNo abstract availableEditorial: The changing face of adult surgical education: a positive 'disruption' for more than just millennialsNo abstract availableFacial reanimation: an update on nerve transfers in facial paralysisPurpose of review The aim of this article is to review the recent literature on nerve transfers in facial paralysis. The discussion focuses on direct nerve repair and three types of nerve transfers, cross facial nerve graft, hypoglossal, and masseter nerve...
In-Hospital Initiation of Sacubitril/Valsartan: A New PARADIGM for Acute Decompensated Heart Failure?No abstract availableThe incidence and prevalence of heart failure (HF) is not decreasing, and its morbidity remains extremely high1,2 with future projections predicting further increases in incidence and costs over the next 20 years.1Neurohormonal pathways [eg, renin–angiotensin–aldosterone system (RAAS) and the sympathetic nervous system] have long been recognized as playing an important role in...
In-Hospital Initiation of Sacubitril/Valsartan: A New PARADIGM for Acute Decompensated Heart Failure?No abstract availableBioactive Lipids as Mediators of the Beneficial Actions of StatinsNo abstract availableTranslational Implications for Targeting Ischemia-Induced Cardiac Inflammation by Ticagrelor: One Fits All or Dose Matters?No abstract availableTicagrelor Reduces Ischemia-Reperfusion Injury Through the NF-κB–Dependent Pathway in RatsAbstract: We recently showed that ticagrelor reduced myocardial...
3ο ΠΟΛΥΘΕΜΑΤΙΚΟ Επιστημονικό Συνέδριο "ΝΟΣΟΚΟΜΕΙΟ ΚΑΤ" 28 - 30 Νοεμβρίου 2019 │ Αθήνα │ Νοσοκομείο ΚΑΤΒρισκόμαστε στην ευχάριστη θέση να σας ανακοινώσουμε τη διεξαγωγή του3ου ΠΟΛΥΘΕΜΑΤΙΚΟΥ ΕΠΙΣΤΗΜΟΝΙΚΟΥ ΣΥΝΕΔΡΙΟΥ το οποίο διοργανώνει το Ελληνικό Κολλέγιο Χειρουργών σε συνεργασία με το Νοσοκομείο ΚΑΤ και πρόκειται να πραγματοποιηθείαπό 28 - 30 Νοεμβρίου 2019, στο αμφιθέατρο του Νοσοκομείου ΚΑΤ.Η ευρεία θεματολογία του συνεδρίου θα αναπτυχθεί σε στρογγυλές τράπεζες, διαλέξεις, κλινικά φροντιστήρια...
Preventing Invasive Fungal Infections in Hematologic PatientsNo abstract availableInvasive fungal infections (IFIs) are common, preventable infections in those oncology patients who receive hematopoietic stem cell transplantation (HSCT) or therapies for hematologic malignancies. The highest risk periods of neutropenia and graft-versus-host disease (GVHD) treatment, host immune function, prevention strategies, treatment modalities, donor types, and transplant complications can predispose patients...
Preventing Invasive Fungal Infections in Hematologic PatientsNo abstract availableTumor Mutation Burden & Checkpoint Inhibitors in MSI-H Colorectal CancerNo abstract availableSIRT1 Plays Key Role in Chronic Myeloid LeukemiaNo abstract availableWalking Speed & Future Clinical Outcomes for Older Patients With Blood CancersNo abstract availableLeadership: What Are We Looking for?No abstract availableForging Therapies for Pediatric Patients for Whom Progress Has StalledNo abstract availableThe...
Critical Illness and Cardiac Dysfunction in Anthracycline-Exposed Pediatric Oncology Patients*Objectives: To determine if the presence of cardiac dysfunction in anthracycline-exposed pediatric oncology patients is associated with an increased frequency of PICU admission or mortality. Design: Retrospective parallel cohort study. Setting: PICU at an academic freestanding children's hospital. Subjects: Children with oncologic diagnoses who received anthracyclines between January 2006 and December 2014...
Investigating the Causal Mechanisms of Symptom Recovery in Chronic Whiplash-associated Disorders Using Bayesian NetworksObjectives: The present study's objective was to understand the causal mechanisms underpinning the recovery of individuals with whiplash-associated disorders (WAD). We applied Bayesian Networks (BN) to answer 2 study aims: (1) to identify the causal mechanism(s) of recovery underpinning neck-specific exercise (NSE), and (2) quantify if the cyclical pathway of the fear-avoidance...
Preoperative Intravenous Ketorolac Safely Reduces Postoperative Pain in Levator Advancement SurgeryPurpose: To assess the impact of intravenous ketorolac (IVK) on self-reported pain scores, requirements for opioid analgesic and anti-emetic medications, and bleeding complications in the setting of levator advancement surgery Methods: A prospective randomized controlled trial was performed among adult patients undergoing levator advancement surgery. Pain scores were measured immediately after surgery,...
The Incidence of Lacrimal Drainage Disorders Across a Tertiary Eye Care Network: Customization of an Indigenously Developed Electronic Medical Record System—eyeSmartPurpose: To assess the incidence of lacrimal drainage disorders across a tertiary eye care network in India. Methods: A 5-year retrospective review of all the patients who were diagnosed with lacrimal drainage disorders across the tertiary care network of L.V. Prasad Eye Institute was performed from January 2013 to December 2017. All...
Perfusion Monitoring Shows Minimal Blood Flow From the Flap Pedicle to the Tarsoconjunctival FlapBackground: A previous study in pigs has shown that the pedicle of the tarsoconjunctival flap does not appear to have adequate blood perfusion. The aim of this study was to monitor perfusion in tarsoconjunctival flaps in patients with large lower eyelid defects resulting from tumor surgery. Methods: The modified Hughes procedure was performed in 13 patients. Blood perfusion was monitored using laser Doppler...
Acquired Obliteration of the Proximal Lacrimal Drainage SystemPurpose: We present a series of patients with acquired obliteration of one or more components of the proximal lacrimal drainage system, including puncta and canaliculi. This finding was noted with and without other obstructions or stenoses of the lacrimal drainage system. Review of these patients in search of possible risk factors for this condition and histopathology of two patients are presented. Methods: Medical records of patients...
Study on the Aging Dynamics of the Periorbital Region: From Observation to Knowledge of PhysiopathologyPurpose: Several anatomical and physio-pathologic studies of eyelid region have allowed the creation of theories on facial tissues aging dynamics, which have not been clarified yet. We assessed the signs of aging in the region over the time by observing the characteristics in the same person at different times of his/her life. Methods: We compared the position of the main anatomical landmarks of...
Fractionated Stereotactic Radiotherapy for Cavernous Venous Malformations of the Orbital ApexPurpose: The objective of this study was to investigate the efficacy and safety of fractionated stereotactic radiotherapy in the treatment of cavernous venous malformation of the orbital apex. Methods: The authors reviewed a prospective database from a single center of patients with cavernous venous malformation of the orbital apex who had treatment with fractionated stereotactic radiotherapy. The authors...
Congenital Dacryocystocele: A Major ReviewPurpose: To provide a systematic review of the literature on congenital dacryocystoceles (CDCs) and summarize their presentations, investigations, management, and outcomes. Methods: The authors performed a PubMed search of all articles published in English on CDCs. Data captured include demographics, clinical presentations, investigations, management modalities, complications, and outcomes. Fourteen major series (10 or more than 10 cases) and 89 isolated...
A Prospective Comparative Study Between Subcuticular and Sutureless Technique of Skin Closure Following External DacryocystorhinostomyPurpose: To compare the cosmetic outcome of the surgical scar of external dacryocystorhinostomy by the subcuticular versus sutureless technique. Methods: This was a prospective interventional randomized control study conducted at tertiary level hospital. Fifty patients of primary-acquired nasolacrimal duct obstruction were included in this study. The control group...
Congenital Dacryocystocele: A Major Review,Purpose: To provide a systematic review of the literature on congenital dacryocystoceles (CDCs) and summarize their presentations, investigations, management, and outcomes. Methods: The authors performed a PubMed search of all articles published in English on CDCs. Data captured include demographics, clinical presentations, investigations, management modalities, complications, and outcomes. Fourteen major series (10 or more than 10 cases) and 89 isolated...
Subtenon Bupivacaine for Postoperative Pain in Patients Undergoing Pterygium Excision: A Double-Blinded Randomized Control TrialPurpose: Patients undergoing primary pterygium excision with autologous conjunctival autograft and human tissue adhesive in New Zealand, currently receive subconjunctival anesthesia with oral postoperative analgesia for pain. Our aim was to investigate the potential added benefit of intraoperative subtenon bupivacaine to this regimen. Methods: A double-blinded, placebo-controlled,...
Safety and Efficacy of Supratarsal Triamcinolone for Treatment of Vernal Keratoconjunctivitis in IrelandPurpose: To describe the clinical features, risk factors, and treatment outcomes after supratarsal injection of triamcinolone for vernal keratoconjunctivitis (VKC). Methods: A retrospective review of all patients treated with supratarsal triamcinolone for VKC between February 2002 and May 2017 at the Royal Victoria Eye and Ear Hospital and Our Lady's Children Hospital Crumlin, Dublin, Ireland,...
Toxic Keratitis After Application of Custard Apple Seed for Head Lice Infestation,Purpose: To report the clinical features and outcomes of toxic keratitis after application of powdered custard apple seeds for hair washing for head lice infestation. Methods: Retrospective review of all patients with toxic keratitis after application of powdered custard apple seed for head lice infestation during the time period from January 2015 to December 2017. Demographic details, clinical features, and visual...
Microbial Keratitis in Stevens–Johnson Syndrome: A Prospective Study,Purpose: To evaluate the microbiological profile and outcome in cases with infective keratitis in Stevens–Johnson syndrome (SJS). Methods: Eighty-three eyes of 68 patients with SJS presenting with microbial keratitis were recruited and managed with standard antimicrobial therapy. Results: Microbial keratitis developed in 34% of patients with SJS (83 eyes, 68 patients) over a period of 5 years. Four eyes (4.8%) had a history of concurrent...
Medication Burden for Patients With Bacterial KeratitisPurpose: To understand medication use and patient burden for treatment of bacterial keratitis (BK). Methods: A retrospective study was conducted examining medical records of adult patients with BK in an academic cornea practice. Data collected included medications used in the treatment of BK, dosing of medications, and the number and total duration of clinical encounters. Costs of medications were estimated using the average wholesale pharmacy...
Hypocalcemia and Massive Blood Transfusions: A Pilot Study in a Level I Trauma Center,Trauma is a leading cause of death in the United States, and uncontrolled hemorrhage is often the primary cause of mortality. Massive transfusions provide lifesaving treatment for the bleeding trauma patient; yet, this is not a benign intervention. Calcium levels can be significantly decreased with rapidly transfused blood products due to the citrate preservative that is added. Citrate binds to the patient's endogenous...
The Year AheadNo abstract availableEthics at Work: What Nurses Really Do on the JobNo abstract availableNurse Practitioners' Role in Improving Service for Elderly Trauma PatientsPreexisting conditions and decreased physiological reserve in the elderly frequently complicate the provision of health care in this population. A Level 1 trauma center expanded its nurse practitioner (NP) model to facilitate admission of low-acuity patients, including the elderly, to trauma services. This model enabled NPs...
Estimated Life-Time Savings in the Cost of Ongoing Care Following Specialist Rehabilitation for Severe Traumatic Brain Injury in the United KingdomObjectives: To evaluate cost-efficiency of rehabilitation following severe traumatic brain injury (TBI) and estimate the life-time savings in costs of care. Setting/Participants: TBI patients (n = 3578/6043) admitted to all 75 specialist rehabilitation services in England 2010–2018. Design: A multicenter cohort analysis of prospectively collated clinical...
Diagnosis and TreatmentLee, Yu-Po MD; Farhan, Saif Aldeen MD; Musa, Arif MS; Bhatia, Nitin MDContemporary Spine Surgery: August 2019 - Volume 20 - Issue 8 - p 1–7doi: 10.1097/01.CSS.0000576664.27465.d4
Prognostic value of average real variability of systolic blood pressure in elderly treated hypertensive patientsObjective: The independent prognostic significance of ambulatory blood pressure variability in the elderly is incompletely clear. We investigated the prognostic value of average real variability of 24-hour blood pressure in elderly treated hypertensive patients. Methods: The occurrence of a combined end-point including stroke, coronary events, heart failure requiring hospitalization and...
Future use of the European Society of Hypertension International Protocol for validation of automated sphygmomanometersNo abstract availableValidation protocols for blood pressure measuring devices: the impact of the European Society of Hypertension International Protocol and the development of a Universal StandardIn the last three decades protocols for the validation of blood pressure measuring devices have been developed by the US Association for the Advancement of Medical Instrumentation, the...
Exercise Professionals in the Cancer Center: Experiences, Recommendations, and Future Research,In 2018, the Clinical Oncology Society of Australia published a landmark position statement calling for exercise to be integrated as standard practice in cancer care. Efforts to implement this directive in the years ahead will come with many practical challenges. We suggest that for the successful integration of exercise therapy to occur, exercise professionals and their services will have to become a respected,...
The Science of Being a Charge NurseNo abstract availableExecutive Summary: Post–Intensive Care Syndrome in the Neurocritical Intensive Care UnitNo abstract availableResolving Clinical Trial Subject Disengagement in Socioeconomically Disadvantaged SubjectsBACKGROUND: Clinical trialists may be reluctant to enroll socioeconomically disadvantaged participants because of concerns for subject disengagement leading to noncompliance with longitudinal measures and high lost to follow-up (LTFU) rates. OBJECTIVES:...
Subcutaneous Immunoglobulin Therapy for Chronic Inflammatory Demyelinating Polyneuropathy: A Nursing PerspectiveChronic inflammatory demyelinating polyneuropathy (CIDP), an immune-mediated peripheral neuropathy, is frequently treated with long-term maintenance intravenous immunoglobulin (IVIG). However, disadvantages of IVIG are the systemic adverse reactions, lengthy infusions, and need for vascular access. Subcutaneous immunoglobulin (SCIG) addresses many of the issues encountered by those unable,...
Successful Intrathecal Rituximab Administration in Refractory Nonteratoma Anti–N-Methyl-D-Aspartate Receptor Encephalitis: A Case ReportN-methyl-D-aspartate receptor (NMDA-R) antibody encephalitis is an immune-mediated disorder characterized by the presence of anti-NMDA antibody in serum and cerebrospinal fluid, with a characteristic combination of psychological and neurological signs and symptoms. The scientific knowledge pertaining to the management of anti–NMDA-R encephalitis is growing. It is...
Acute Flaccid Myelitis,Acute flaccid myelitis is a poliolike illness affecting mainly children, which seems to occur every 2 years in the late summer and early fall. The 2018 outbreak was alarming to parents and healthcare providers because the etiology is still under investigation and long-term outcomes are unclear. Becoming familiar with what is known about the epidemiology and clinical characteristics of acute flaccid myelitis enables neuroscience nurses to disseminate accurate information and...
Pupillary Light Reflex Variability as a Predictor of Clinical Outcomes in Subarachnoid Hemorrhage,BACKGROUND: A change in the pupillary light reflex (PLR) is a sensitive indicator for detecting expanding intracranial lesions. Changes in PLR may be a prognostic marker for patients with intracranial lesions. The purpose of this analysis was to explore how PLR readings, size, constriction velocity (CV), dilation velocity (DV), Neurologic Pupil Index (NPi), and latency predict clinical outcome in patients...
The Legacy of Lillian WaldNo abstract availableChronic Heart Failure Treatment With the Left Ventricular Assist DeviceThe prevalence of chronic heart failure is increasing in the United States due to the increase in the number of older adults and because many people are surviving acute cardiac events and living longer with chronic heart disease. In end-stage heart failure, heart transplant was once the gold standard of treatment and patients had to wait for a matching heart donor. In the past, the...
Low-Dose Intrathecal Ziconotide for Spasticity From Primary Lateral Sclerosis: A Case ReportSpasticity can be very debilitating and painful. We present a case of severe spasticity from primary lateral sclerosis refractory to intrathecal baclofen in doses up to 1100 μg/d. Baclofen was weaned down and switched to intrathecal ziconotide at 0.6 μg/d. The dose was then titrated up to 3 μg/d with excellent control of spasticity. This case suggests that low-dose intrathecal ziconotide should be considered...
: A Case ReportA 71-year-old man with advanced vocal cord carcinoma presented with severe airway obstruction. Therapeutic anticoagulation with enoxaparin complicated management. Failure of an oral awake bronchoscopic intubation was rescued by passing a guidewire through the working channel and threading an Arndt exchange catheter into the trachea under videoscopic vision. Ventilation with the Ventrain device lasting 40 minutes (15 L/min, inspiration/expiration 1:1, 15 breaths/min), during IV anesthesia...
Nebulized Lidocaine in the Treatment of Refractory Postoperative Laryngospasm: A Case ReportIntraoperative laryngospasm occurs in <1% of cases. Recurrent laryngospasm is rarer. Some risk factors include shared airway and pediatric surgery, secretions, pungent volatile anesthetics, and patient factors, such as smoking and asthma. Conventional management includes the application of positive airway pressure, jaw thrust, the removal of any offending stimuli, deepening anesthesia, or administering...
Efficacy of Sugammadex in Preventing Skin Test Reaction in a Patient With Confirmed Rocuronium Anaphylaxis: A Case ReportThe curative role of sugammadex has been challenged in several observations of rocuronium-induced anaphylaxis because sugammadex may not completely encapsulate the molecule of rocuronium. In such conditions, rocuronium remains able to cause immunoglobulin E cross-linkage and the anaphylaxis mechanism can continue. We describe a case of rocuronium-induced anaphylaxis in which clinical...
Extraluminal Use of a Pediatric Bronchial Blocker With Confirmation by Point-of-Care Ultrasound: A Case ReportLung isolation for pediatric thoracic surgery is especially challenging in a patient with chronic lung infection and need to protect the nonoperative lobes from the spread of infection during anesthesia and surgery. Typically, for pediatric thoracic surgery, a mainstem intubation or placement of an intraluminal bronchial blocker is sufficient for lung isolation. The patient whose case is...
Successful Use of Cangrelor and Heparin for Cardiopulmonary Bypass in a Patient With Heparin-Induced Thrombocytopenia and End-Stage Renal Disease: A Case ReportHeparin is the only well-established anticoagulant medication for cardiopulmonary bypass making selecting an alternative anticoagulant challenging in patients with heparin-induced thrombocytopenia. Other anticoagulant medications can cause significant postoperative bleeding, especially in patients with end-stage renal disease. We present a...
Supraglottic Airway Rescue After Failed Fiberoptic Intubation in a Patient With Osteogenesis Imperfecta: A Case ReportWe describe the management of a pregnant patient with osteogenesis imperfecta with a history of numerous fractures, severe scoliosis, and anticipated difficult airway. Her pregnancy was complicated by progressive shortness of breath and a fetal diagnosis of osteogenesis imperfecta. Spine anatomy precluded neuraxial anesthesia. Cesarean delivery was performed under general anesthesia...
Urgent Complex Intraoperative Reintubation in a Known Difficult Airway After Endotracheal Tube Damage: A Case Report,Treacher Collins syndrome is an inherited disorder resulting in maldevelopment of the first and second branchial arches. Patients have complex orofacial anatomy often requiring airway interventions from birth. A 17-year-old boy with Treacher Collins syndrome and history of difficult ventilation and intubation presented for elective maxillofacial reconstruction. After uneventful awake...
Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case ReportEsophageal pH monitoring via wireless probes is used to evaluate chest pain and atypical symptoms and diagnose gastroesophageal reflux. These probes are commonly placed during esophagogastroduodenoscopy performed by gastroenterologists in an ambulatory anesthesia setting. Dislodgment and aspiration of these probes can cause morbidity, require surgical removal, and involve the anesthesia provider in prolonged...
Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case Report,Esophageal pH monitoring via wireless probes is used to evaluate chest pain and atypical symptoms and diagnose gastroesophageal reflux. These probes are commonly placed during esophagogastroduodenoscopy performed by gastroenterologists in an ambulatory anesthesia setting. Dislodgment and aspiration of these probes can cause morbidity, require surgical removal, and involve the anesthesia provider in prolonged...
Drug-Induced Acute-on-Chronic Liver Failure in Asian PatientsDevarbhavi, Harshad; Choudhury, Ashok Kumar; Sharma, Manoj Kumar; Maiwall, Rakhi; Al Mahtab, Mamun; Rahman, Salimur; Chawla, Yogesh K.; Dhiman, Radha K.; Duseja, Ajay; Taneja, Sunil; Ning, Qin; Jia, Ji Dong; Duan, Zhongping; Yu, Chen; Eapen, Chundamannil E.; Goel, Ashish; Tan, Soek Siam; Hamid, Saeed Sadiq; Butt, Amna Subhan; Jafri, Wasim; Kim, Dong Joon; Hu, Jinhua; Sood, Ajit; Midha, Vandana; Shukla, Akash; Ghazinian, Hasmik; Sahu, Manoj...
Gene-Environment Interactions and the Risk of Barrett's Esophagus in Three US CohortsCrous-Bou, Marta; Jovani, Manol; De Vivo, Immaculata; Jacobson, Brian C. LessAmerican Journal of Gastroenterology. 114(6):893-899, June 2019.AbstractFavorites PDF Get Content & PermissionsOBJECTIVES:Several single-nucleotide polymorphisms (SNPs) have been associated with Barrett's esophagus (BE) risk. In addition, environmental factors including smoking, alcohol consumption, and heartburn increase BE risk. However,...
From Latin America With Love (for the Red Journal)No abstract availableEarly Gastric Cancer: Current Limitations and What Can Be Done to Address ThemNo abstract availableIs Post Infection-Irritable Bowel Syndrome Less Frequent in Mexico?No abstract availableChagasic Achalasia: Muscarinic Autoantibodies and Their ActionsNo abstract availableBariatric/Metabolic Surgery in Latin AmericaNo abstract availableEvolving Paradigms in the Diagnosis of Adult Patients With Celiac DiseaseNo abstract availableHematochezia...
: Outcomes and Challenges to Use of Resident Monitoring Technology in a Nursing HomePURPOSE: We examined the usability, user perceptions, and nursing occupational subculture associated with introduction of a patient monitoring system to facilitate nursing staff implementation of standard care for pressure ulcer/injury prevention in the nursing home setting. DESIGN: Mixed methods, pre-/posttest design. SUBJECTS AND SETTING: Resident (n = 44) and staff (n = 38) participants were recruited from a 120-bed...
Epidemiology of Incontinence-Associated Dermatitis and Intertriginous Dermatitis (Intertrigo) in an Acute Care Facility,PURPOSE: The purpose of this study was to measure the prevalence of incontinence-associated dermatitis (IAD) and intertriginous dermatitis (ITD) upon admission, and the incidence of hospital-acquired IAD and ITD in a sample of acutely ill adults. DESIGN: This was a descriptive, retrospective-cohort observational study. SUBJECTS AND SETTING: The sample comprised 417 adults admitted...
Definition and Characteristics of Chronic Tissue Injury: A Unique Form of Skin DamageBACKGROUND: The purpose of this article is to examine the evidence related to a unique phenomenon of purple-maroon discoloration of the buttocks found in homecare patients and to recommend a label for this phenomenon. CASES: Initially, we searched the literature to identify and retrieve any evidence related to this unique form of purple-maroon discoloration of the buttocks. No evidence was found. To illustrate the...
Foot and Nail Care: A New Platform Section in the: Journal of Wound, Ostomy and Continence NursingNo abstract availableCharles Lachenbruch, PhDNo abstract availableDefinition and Characteristics of Chronic Tissue Injury: A Unique Form of Skin DamageBACKGROUND: The purpose of this article is to examine the evidence related to a unique phenomenon of purple-maroon discoloration of the buttocks found in homecare patients and to recommend a label for this phenomenon. CASES: Initially, we searched the...
Assessment of cerebral and renal autoregulation using near-infrared spectroscopy under normal, hypovolaemic and postfluid resuscitation conditions in a swine model: An observational studyBACKGROUND The impact of blood pressure changes on tissue oxygenation differs between vital organs and with blood volume conditions. OBJECTIVE To assess cerebral and renal autoregulation simultaneously and compare the impact of blood pressure, hypovolaemia and fluid resuscitation on tissue oxygenation using near-infrared...
Initial end-tidal carbon dioxide as a predictive factor for return of spontaneous circulation in nonshockable out-of-hospital cardiac arrest patients: A retrospective observational studyBACKGROUND Early outcome prediction in out-of-hospital cardiac arrest is still a challenge. End-tidal carbon dioxide (ETCO2) has been shown to be a reliable parameter to reflect the quality of cardiopulmonary resuscitation and the chance of return of spontaneous circulation (ROSC). OBJECTIVES This study assessed the...
Necessity to depict difficult neck anatomy for training of cricothyroidotomy: A pilot study evaluating two surgical devices on a new hybrid training modelBACKGROUND Everyone dealing with airway emergencies must be able to accomplish cricothyroidotomy, which cannot be trained in real patients. Training models are necessary. OBJECTIVE To evaluate the suitability of a hybrid training model combining synthetic and porcine parts to depict variable neck anatomy. DESIGN Model-based comparative trial. SETTING...
Ultrasound as a new tool in the assessment of airway difficulties: An observational study,BACKGROUND Prediction of difficult mask ventilation (DMV) is as challenging as difficult laryngoscopy. Ultrasound could be a helpful tool in the prediction of these difficulties. OBJECTIVES The purpose of this study was to evaluate the ability of pre-operative ultrasound assessment of neck anatomy in predicting DMV and difficult laryngoscopy in patients undergoing during elective surgery requiring tracheal intubation....
Medical training in anaesthesiology: Updated European requirementsNo abstract availableResistance towards nondepolarising muscle relaxants: prolonged onset time: A systematic reviewBACKGROUND Nondepolarising muscle relaxants (NDMRs) provide optimal conditions for tracheal intubation and improve surgical conditions. Several clinical conditions, diseases and pharmacological interactions have been suggested to cause resistance towards NDMRs that may translate into difficult intubation or inadequate...
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