Update der Onkopedia-Leitlinie für die chronische lymphatische Leukämie (CLL) Websiteswww.haematologie-fokus.de | www.abbvie-care.de/cll Chemotherapiefreie, zeitlich begrenzte Venetoclax-Kombinationstherapie in der Zweitlinie empfohlen Im Zuge des aktuellen Leitlinien-Updates zur chronischen lymphatischen Leukämie (CLL) hat die Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO) die Kombinationstherapie aus Venetoclax (Venclyxto®) und Rituximab durchgängig für die Zweitlinientherapie...
Chondrosarcoma of the jaw: a retrospective series, Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Akram Abdo Almansoori, Hui-Young Kim, Bongju Kim, Soung-Min Kim, Jong-Ho LeeObjectivesLow-grade chondrosarcoma presents with features similar to those of benign lesions, such as chondroma and synovial chondromatosis, increasing the difficulty in reaching an accurate diagnosis preoperatively. In this study, we...
Desmoplastic fibroma associated with tuberous sclerosis: case report and literature review, Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Mina D. Fahmy, Anish Gupta, Ricardo J. Padilla, Annette Segura, Carolyn Dicus BrookesTuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that affects the skin, brain, kidneys, and other organ systems. It may exhibit a wide spectrum of clinical manifestations....
KLF4 expression in the surgical cut margin is associated with disease relapse of oral squamous cell carcinoma,Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Souvick Roy, Madhabananda Kar, Shomereeta Roy, Swatishree Padhi, Arka Saha, Birendranath BanerjeeObjectiveThe presence of cancer stem-like cells (CSCs) in the majority of tumors is one of the factors responsible for disease relapse in oral squamous cell carcinoma...
Upregulation of eukaryotic translation initiation factor 3 subunit a promotes cell survival in ameloblastoma,Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Zhenjiang Ding, Jie Liu, Junting Wang, Biying Huang, Ming ZhongObjectivesThis study aimed to detect the expression of eukaryotic translation initiation factor 3 subunit a (eIF3a) in ameloblastoma (AB) tissues compared with normal oral mucosa (NOM) tissues and investigate...
Chronic treatment with zoledronic acid alters the expression levels of inflammatory, bone, and apoptotic markers and Toll-like receptors 2 and 4 in rat dental pulp,Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira, Camila Carvalho de Oliveira, Maria Elisa Quesado Lima Verde, Milena Oliveira Freitas, Fabrício Bitu Sousa, Mário Rogério Lima Mota, Ana Paula...
Therapeutic efficacy of propranolol for infantile hemangiomas, Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Wenli Wu, Hongtao Wang, Jiansuo Hao, Zijun Gao, Fan Li, Yiyang ChenObjectives.This was a retrospective study to analyze the clinical therapeutic efficacy of propranolol in patients with infantile hemangioma (IH).Study Design.Patients with IH were treated with propranolol (2–4.5 mg/kg/day). Those patients...
Serum and salivary interleukin-4 levels in patients with oral lichen planus: A systematic review and meta-analysis, Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Hamid Reza Mozaffari, Elisa Zavattaro, Mina Saeedi, Pia Lopez-Jornet, Masoud Sadeghi, Mohsen Safaei, Mohammad Moslem Imani, Reza Nourbakhsh, Hedaiat Moradpoor, Amin Golshah, Roohollah SharifiObjectiveCytokines have an important role in keratinocyte...
Risk factors for caries development in primary Sjogren syndrome,Publication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Nicola Berman, Frederick Vivino, Joshua Baker, Jonathan Dunham, Andres PintoObjectivesThe aim of this study was to compare the risk factors for caries between patients with primary Sjogren syndrome (SS) and those with non-Sjogren syndrome (NSS) salivary hypofunction and to identify the prevalence of incisal...
An, Miranda B. BS; Rotunda, Adam M. MDDermatologic Surgery: July 09, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/DSS.0000000000002026Commentary: PDF OnlyBUYPAPAuthor InformationArticle Metrics© 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Routt, Ethan MD; Ratner, Desiree MDDermatologic Surgery: July 01, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/DSS.0000000000001985Letters and Communications: PDF OnlyBUYPAPAuthor InformationArticle Metrics© 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Baltz, Julia O. MD; Jellinek, Nathaniel J. MDDermatologic Surgery: July 01, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/DSS.0000000000001998Commentary: PDF OnlyBUYPAPAuthor InformationArticle Metrics© 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Chondrosarcoma of the jaw: a retrospective seriesPublication date: August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 2Author(s): Akram Abdo Almansoori, Hui-Young Kim, Bongju Kim, Soung-Min Kim, Jong-Ho LeeObjectivesLow-grade chondrosarcoma presents with features similar to those of benign lesions, such as chondroma and synovial chondromatosis, increasing the difficulty in reaching an accurate diagnosis preoperatively. In this study, we retrospectively...
Introducing the L-Lift—A Novel Approach to Treat Age-Related Facial Skin Ptosis Using A Collagen StimulatorNo abstract availableCommentary on Intralesional Deoxycholic Acid as a Neoadjuvant Treatment for a Large LipomaNo abstract availableTime to Move on From Prescribing Oral Antibiotics as Prophylaxis for Mohs?No abstract availableOutcomes for Basal Cell Carcinoma Treated With Vismodegib Extended Alternate Day DosingNo abstract availableCommentary on Transungual Excision of Glomus TumorsNo abstract...
Selim Berker's Combinatorial Argument against Practical Reasons for Belief,AbstractIn a recent paper, Selim Berker (Analytic Philosophy, 59, 427-470, 2018) develops an abductive argument against practical reasons for belief that exploits an alleged difference between epistemic and practical reasons. According to Berker, epistemic reasons for belief balance to suspension. If I have equally strong epistemic reasons to believe and disbelieve some proposition, I lack sufficient reason either to believe...
Merkelzellkarzinom, ZusammenfassungDas Merkelzellkarzinom ist ein seltener, hoch aggressiver Hauttumor des älteren Menschen. Er besitzt neuroendokrine Eigenschaften. Die Pathogenese ist mit chronischer UV-Licht-Exposition und dem Merkelzell-Polyomavirus assoziiert. Klinisch fällt das Merkelzellkarzinom durch einen solitären, kutan oder subkutan gelegenen, roten bis bläulichen Knoten auf. Da der Tumor frühzeitig lymphogen metastasiert, sind zum Zeitpunkt der Diagnosestellung in etwa 30 % der Fälle...
Management gutartiger Hirntumoren: Meningeome und Vestibularisschwannome,ZusammenfassungMeningeome und Vestibularisschwannome zählen zu den gutartigen intrakraniellen Tumoren und gehen von den Hirnhäuten bzw. den Hirnnerven aus. Die Inzidenz ist mit 4,1 bzw. 1 Neuerkrankung/100.000 Einwohner sehr niedrig, wobei die Anzahl mittels Magnetresonanztomographie (MRT) steigt. Erstbefunde zufällig entdeckter Tumoren ohne neurologisches Defizit, ohne Symptomatik und ohne wesentliche Raumforderung können zunächst...
Jüngste Entwicklungen in der Kopf-Hals-Immunologie,ZusammenfassungImmunologische Vorgänge spielen eine wesentliche Rolle bei der Pathogenese von Erkrankungen des Kopf-Hals-Bereichs. In diesem Zusammenhang ist nicht nur an Allergien oder an Infektionen im Bereich der Mandeln, der Nasennebenhöhlen und des Ohres zu denken, auch Entstehung, Wachstum und Metastasierung von malignen Tumoren des Kopf-Hals-Bereichs werden maßgeblich vom Immunsystem beeinflusst. Die Rekrutierung von weißen Blutkörperchen...
Diagnostik und Therapie der akuten myeloischen LeukämieZusammenfassungIm April 2018 ist die Neuauflage der Onkopedia-Leitlinie zur akuten myeloischen Leukämie (AML) als Aktualisierung von Vorversionen aus den Jahren 2010 und 2017 erschienen. Zwei wesentliche positive Entwicklungen auf dem Gebiet dieser immer noch schwer zu behandelnden Erkrankung machten die Überarbeitung erforderlich: erstens neue Erkenntnisse zu Risikostratifizierung und Monitoring und zweitens die Entwicklung und Zulassung neuer...
Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrP V180I MutationThe original version of this article unfortunately contained a mistake. The email address Dr. Wen-Quan Zou, one of the corresponding authors should be written as "wxz6@case.edu" instead of "wxz@case.edu".Correction to: Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain...
AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck,AbstractSalivary gland malignancies of the head and neck form a heterogeneous group. Adenoid cystic carcinomas are an aggressive entity of salivary gland malignancies characterized by frequent distant metastases and poor response to radio- and chemotherapy. AF1Q is a MLL fusion partner, which can activate Wnt and STAT3 signaling. Recently, overexpression of AF1q has been identified...
Molecular Network-Based Identification of Circular RNA-Associated ceRNA Network in Papillary Thyroid Cancer,AbstractCircular RNAs (circRNAs) have displayed dysregulated expression in several types of cancer. Nevertheless, their function and underlying mechanisms in papillary thyroid cancer (PTC) remains largely unknown. This study aimed to describe the regulatory mechanisms in PTC. The expression profile of circRNA was download from the Gene Expression Omnibus (GEO) database. The mRNA and miRNA data...
Upregulation of RUNX1 Suppresses Proliferation and Migration through Repressing VEGFA Expression in Hepatocellular CarcinomaAbstractHepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and occurs in people with chronic liver diseases. Current treatment methods include surgery, transplant, and chemotherapy. Our study demonstrates runt-related transcription factor 1 (RUNX1) as a novel molecule in the initiation and development of HCC, and the role of its interaction with...
Open doors, open mindPlädoyer für eine offene Versorgungspsychiatrie,https://link.springer.com/article/10.1007/s00115-019-0715-5?wt_mc=alerts.TOCjournals&utm_source=toc&utm_medium=email&utm_campaign=toc_115_90_7AuthorsAuthors and affiliationsKarl H. Beine1Email author1.Universität Witten/Herdecke – Klinik für Psychiatrie, Psychotherapie und PsychosomatikSt. Marien-Hospital HammHammDeutschlandLeitthemaFirst Online: 23 April 2019142DownloadsZusammenfassungGegen ihren natürlichen Willen...
Wodurch wird die geschlossene Tür ersetzt?Konzeptionelle und ethische Überlegungen zu offenen Unterbringungsformen, formellem Zwang und psychologischem Druck,https://link.springer.com/article/10.1007/s00115-019-0717-3?wt_mc=alerts.TOCjournals&utm_source=toc&utm_medium=email&utm_campaign=toc_115_90_7AuthorsAuthors and affiliationsJakov Gather12Email authorMatthé Scholten2Tanja Henking3Jochen Vollmann2Georg Juckel11.Klinik für Psychiatrie, Psychotherapie und Präventivmedizin, LWL-UniversitätsklinikumRuhr-Universität...
Korrektur des Empfehlungsgrades für TDM(Teil-)stationäre Therapie von Voll- und Minderjährigen mit einer hyperkinetischen Störung in der deutschen PsychiatrieZusammenfassungHintergrundDie Datenlage über die (teil-)stationäre Versorgung von Patienten mit einer hyperkinetischen Störung (HKS, ICD: 10 F90.-) ist durch Routinedatenanalysen aus dem ambulanten Behandlungssektor bzw. aus gemischten Stichproben einzelner Krankenkassen geprägt. Diese Studie analysiert erstmalig eine fallbezogene Stichprobe...
Effect of inulin polymerization degree on various properties of synbiotic fermented milk including Lactobacillus acidophilus La-5 and Bifidobacterium animalis Bb-12,Publication date: August 2019Source: Journal of Dairy Science, Volume 102, Issue 8Author(s): Sebnem Ozturkoglu-Budak, H. Ceren Akal, İlkay Buran, Atila YetişemiyenABSTRACTThe effects of inulin degree of polymerization (DP) on the viabilities of Lactobacillus acidophilus La-5 and Bifidobacterium animalis Bb-12 and on some parameters of...
Towards Holistic Supporting of Play-Based Learning Implementation in Kindergartens: A Mixed Method Study, AbstractUsing a holistic support framework, this study investigated teachers' conceptions of effective play-based learning development and how their perceptions of its effectiveness related to whole-child development. Data were collected from a mixed method study. A total of 286 questionnaires from 50 Hong Kong kindergartens were collected and then 29 principals, head teachers and teachers...
Shared Musical Experiences, Brandon Polite
LncRNA TUG1 promotes cisplatin resistance in esophageal squamous cell carcinoma cells by regulating Nrf2, Zhenghua Zhang; Ran Xiong; Caiwei Li; Meiqing Xu; Mingfa Guo, IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling, Xiaolin Wang; Yan Li; Zhenzhen Zhao; Yan Meng ; Jinjun Bian ... Immunomodulatory effect of human amniotic epithelial cells on restoration of ovarian function in mice with autoimmune ovarian disease Qiuwan Zhang; Yating Huang; Junyan Sun; Tingting...
Editorials Editorial Kenneth Aldape New developments and new dilemmas in lower-grade gliomas Roberta Rudà Proton beam therapy in pediatric brain tumor patients: improved radiation delivery techniques improve neurocognitive outcomes Rakesh Jalali; Jayant S Goda Diet and risk of glioma: targets for prevention remain elusive Kyle M Walsh; Elizabeth B Claus Highlights from the Literature Highlights from the Literature Roger Abounader; Krishna Bhat ; Riccardo Soffietti; Sourav Ghosh ; Mariano...
HIV Pre-Exposure Prophylaxis and Increased Incidence of Sexually Transmitted Infections in the United States, Jose A Serpa, MD, MS; Gabriel N Huynh, PharmD, MBA; Julie B Nickell, BBA, MBA ; Hongyu Miao, MS, PhD
S Loi, The ESMO clinical practise guidelines for early breast cancer: diagnosis, treatment and follow-up: on the winding road to personalized medicine,
Intestinal dysbiosis mediates experimental autoimmune pancreatitis via activation of plasmacytoid dendritic cells, Ken Kamata; Tomohiro Watanabe; Kosuke Minaga; Akane Hara; Tomoe Yoshikawa ...
Genome-wide association study of piscine myocarditis virus (PMCV) resistance in Atlantic salmon (Salmo salar), Borghild Hillestad; Hooman K Moghadam, High frequency of multiple paternity in Eastern red bats, Lasiurus borealis, based on microsatellite analysis, Loren K Ammerman; Dana N Lee; Brittney A Jones ; Morgan P Holt; Samuel J Harrison ...
Clinical Pharmacokinetic and Pharmacodynamic Considerations in the (Modern) Treatment of Melanoma, AbstractTargeted therapies, based on identification of common oncogenic mutations such as BRAF V600E/K and monoclonal antibody immunotherapies, have transformed the treatment of melanoma. Dual mitogen-activated protein kinase (MAPK) pathway inhibition of BRAF V600E/K and MEK 1/2 kinases with BRAF–MEK inhibitors using dabrafenib–trametinib, vemurafenib–cobimetinib and encorafenib–binimetinib...
Population-Pharmacokinetic Modeling of Tildrakizumab (MK-3222), an Anti-Interleukin-23-p19 Monoclonal Antibody, in Healthy Volunteers and Subjects with PsoriasisAbstractBackgroundTildrakizumab is an anti-interleukin-23p19 monoclonal antibody recently approved for the treatment of chronic plaque psoriasis.MethodsThis analysis characterizes the population pharmacokinetics of subcutaneous tildrakizumab and identifies covariates influencing exposure in 2098 healthy volunteers and subjects with psoriasis....
Enjeux majeurs de santé publique versus autonomie personnelle : le cas spécifique de l'obligation vaccinalePublication date: June 2019Source: Médecine & Droit, Volume 2019, Issue 156Author(s): Marion TraversRésuméSi la triple dimension individuelle, altruiste et collective de l'obligation vaccinale préventive sert un objectif de santé publique majeur, il n'empêche qu'en imposant une contrainte aux individus et en portant ainsi atteinte à plusieurs de leurs droits fondamentaux, un tel choix des...
Intersectionality and Critical Realism: A Philosophical Framework for Advancing Nursing Leadership, This article presents intersectionality theory with critical realism as a philosophical framework for studying nursing leadership. In response to gaps in the current leadership literature, the aim is to develop an approach that addresses how the multiple social positions nurses hold can create an intersecting matrix of oppression that impacts on their opportunities to develop as leaders....
Analyzing Patients' Complaints: Awakening of the Ethic of Belonging, Nursing ethics are fundamental principles to nursing practice. The purpose of this study is to analyze patients' complaints filed against nurses from a nursing ethics perspective. This is a qualitative study. The data source is the patients' complaints filed in a university-affiliated hospital in China. The complaints are categorized into 4 themes: uncompassionate attitudes, unprofessional communication, disrespect...
Letter to the EditorNo abstract availableLetter to the EditorNo abstract availableReconceptualizing the Electronic Health Record for a New Decade: A Caring Technology?Since the 2009 publication by Petrovskaya et al on, "Dilemmas, Tetralemmas, Reimagining the Electronic Health Record," and passage of the Health Information Technology for Economic Clinical Health (HITECH) Act, 96% of hospitals and 78% of providers have implemented the electronic health record. While many positive outcomes such as guidelines-based...
An Unusual Case of Foot Weakness Caused by Proximal Extensor Hallucis Longus (EHL) RuptureNo abstract availablePatients with spinal muscular atrophy use high percentages of trunk muscle capacity to perform seated tasksObjective To investigate trunk function during seated upper extremity tasks in patients with spinal muscular atrophy (SMA) type 2 and 3. Design 17 persons with SMA and 15 healthy controls (HC) performed several tasks when sitting unsupported, such as reaching (and placing) forward and...
THE ARTS AND MEDICINEBasch Unbound—The House of God and Fiction as Resistance at 40Stephen Bergman, MD, DPhilVideo — The Making of The House of GodVideo — The House of God at 40: The Characters SpeakOPINIONJAMAAdvances in Understanding the Pathophysiology of Chronic Fatigue SyndromeAnthony L. Komaroff, MDJAMA Internal MedicineIgnorance of Nutrition Is No Longer DefensibleNeal D. Barnard, MDJAMA PsychiatryDisruptive PsychopharmacologyBoris D. Heifets, MD, PhD; Robert C. Malenka, MD, PhDJAMA CardiologyFear-Based...
Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child, Objectives: Adverse physiology and antibiotic exposure devastate the intestinal microbiome in critical illness. Time and cost implications limit the immediate clinical potential of microbial sequencing to identify or treat intestinal dysbiosis. Here, we examined whether metabolic profiling is a feasible method of monitoring intestinal...
Management of Peripheral Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock, Objectives: Cardiogenic shock is a highly morbid condition in which inadequate end-organ perfusion leads to death if untreated. Peripheral venoarterial extracorporeal membrane oxygenation is increasingly used to restore systemic perfusion despite limited understanding of how to optimally titrate support. This review provides insights into the physiologic basis of extracorporeal membrane...
Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy, Objectives: Electroencephalogram features predict neurologic recovery following cardiac arrest. Recent work has shown that prognostic implications of some key electroencephalogram features change over time. We explore whether time dependence exists for an expanded selection of quantitative electroencephalogram features and whether accounting for this time dependence enables better prognostic...
Effect of Prone Positioning on Intraocular Pressure in Patients With Acute Respiratory Distress Syndrome,Objectives: To evaluate the effect of prolonged duration of prone position (with head laterally rotated) on intraocular pressure in acute respiratory distress syndrome patients. Design: Prospective observational study. Setting: University hospital ICU. Patients: Twenty-five acute respiratory distress syndrome patients, age 60 years (51–67 yr), Sequential Organ Failure Assessment score 10 (10–12),...
Implementation of a Bundled Consent Process in the ICU: A Single-Center ExperienceObjectives: A bundled consent process, where patients or surrogates provide consent for all commonly performed procedures on a single form at the time of ICU admission, has been advocated as a method for improving both rates of documented consent and patient/family satisfaction, but there has been little published literature about the use of bundled consent. We sought to determine how residents in an academic medical...
Tryptase values in anaphylaxis and insect allergy, Purpose of review To recognize the relevance of serum tryptase measurement as a useful tool for the diagnosis of allergic diseases and mast cell disorders. Recent findings Recent data on the role of mast cells and tryptase in allergic and other diseases provide new understanding into the mechanisms and causes of anaphylaxis. Summary Measurement of transiently elevated tryptase levels shortly after a severe reaction can...
Multimodal analgesia for craniotomy, Purpose of review To explore the data for and against the use of the various components of multimodal analgesia in cranial neurosurgery. Recent findings Postcraniotomy pain is a challenging clinical problem in that analgesia must be accomplished without affecting neurologic function (i.e. 'losing the neurologic exam'). The traditional approach with low-dose opioids is often insufficient and can cause well recognized side effects. Newer multimodal...
Indications for treatment of sarcoidosis, Purpose of review To describe the current knowledge on indications for sarcoidosis treatment. Recent findings Despite the lack of evidence-based recommendations, the sarcoidosis community has adopted the concept of starting systemic anti-inflammatory treatment because of potential danger (risk of severe dysfunction on major organs or death) or unacceptable impaired quality of life (QoL). On the contrary, while QoL and functionality are patients' priorities,...
Approach to tapering antisarcoidosis therapyPurpose of review Sarcoidosis is a multisystemic granulomatous disease, which commonly affects the lung. The natural course of the disease and prognosis are variable from asymptomatic, spontaneous remission to progressive disease, which requires treatment. Once treatment is initiated, tapering therapy can be problematic. Recent findings Corticosteroids are recommended as first-line therapy, but optimal regimen and duration of treatment is not well established....
Conversion from Twice-Daily Prograf ® to Once-Daily Advagraf ® in Multi-ethnic Asian Adult Renal Transplant Recipients With or Without Concomitant Use of Diltiazem: Impact of CYP3A5 and MDR1 Genetic Polymorphisms on Tacrolimus ExposureAbstractBackground and ObjectivesTacrolimus is the mainstay of immunosuppression in renal transplantation. Given that once-daily administration improves patient compliance, 1:1 dose conversion from twice-daily Prograf® to once-daily Advagraf® is recommended. Although...
Ultrasound Time-Harmonic Elastography of the Aorta: Effect of Age and Hypertension on Aortic StiffnessObjectives The aim of this study was to investigate ultrasound time-harmonic elastography for quantifying aortic stiffness in vivo in the context of aging and arterial hypertension. Materials and Methods Seventy-four participants (50 healthy participants and 24 participants with long-standing hypertension) were prospectively included between January 2018 and October 2018, and underwent ultrasound...
Vereinbarung zur Organisation der Schmerztherapie chirurgischer Patienten des Berufsverbandes Deutscher Anästhesisten und des Berufsverbandes der Deutschen Chirurgen (Neufassung 2019)ZusammenfassungDie Therapie möglicher ursächlicher, prozedurenspezifischer und/oder -begleitender Akutschmerzen ist ein essenzielles Qualitätsmerkmal in jedem chirurgischen Fachgebiet. Ziele einer interdisziplinären und interprofessionellen Schmerztherapie sind unmittelbar eine Verbesserung der Lebensqualität durch Schmerzfreiheit,...
Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β 1–42 levelAbstractRepetitive transcranial magnetic stimulation (rTMS) is a technique protecting neurons against diverse neurodegenerative disorders by delivering magnetic stimuli into the brain through the intact scalp. In the current study, the protection effect of rTMS on Parkinson's disease (PD) and the associated mechanism driving the treatment were explored....
Berberine enhances posttranslational protein stability of p21/cip1 in breast cancer cells via down-regulation of AktAbstractBerberine has shown anticancer properties and has potential for a chemopreventive and/or chemotherapeutic agent for breast cancer. Berberine showed cytotoxicity to breast cancer cells, with an increase in the levels of p21/cip1 and p27/kip1, cyclin-dependent kinase inhibitors (CDKI), but mechanisms involved in up-regulating these molecules are largely unknown. Herein, we studied...
Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin,AbstractThe aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old) were divided into five groups: three experimental and two control groups. Animals in all groups were treated with a dose of 4 mg/kg body weight once a...
Exosomes derived from microRNA-101-3p-overexpressing human bone marrow mesenchymal stem cells suppress oral cancer cell proliferation, invasion, and migrationAbstractDysregulation of microRNAs (miRNAs) has been found to disrupt the progression of oral cancer. However, which miRNAs are most effective against oral cancer and how these miRNAs should be delivered are major unanswered problems. We aimed at investigating if human bone marrow mesenchymal stem cells (hBMSCs)-derived exosomes affect oral...
Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosisAbstractCardiac remodeling characterized by cardiac fibrosis is a pathologic process occurring after acute myocardial infarction. Fibrosis can be ameliorated by interferon-gamma (IFN-γ), which is a soluble cytokine showing various effects such as anti-fibrosis, apoptosis, anti-proliferation, immunomodulation, and anti-viral activities. However, the role of IFN-γ in cardiac myofibroblasts...
Hydrochemical Regime in Riverine Aqual Complexes: Case Study of the Small Il'd River (Rybinsk Reservoir Basin),AbstractThe results of studying the space and time dynamics of the hydrochemical regime in discrete aquatic areas of a riverine aquatic–territorial complex of a small river over period 2001–2010 are given. Each discrete area considered separately has specific features of hydrochemical regime formation.Modelling Technique for Sediment Evaluation at Reservoir (South India)AbstractIn India,...
Christmas as Religion: Rethinking Santa, the Secular, and the Sacred. By Christopher Deacy, Lucinda Murphy
Class, Politics, and the Decline of Deference in England, 1968–2000. By Florence Sutcliffe-Braithwaite, Matthew Kelly, Learning to Fight: Military Innovation and Change in the British Army, 1914–1918. By Aimée Fox, Laura Boyd,
Environmental, Social, and Governance Investment: Opportunities and Risks for Asia, https://www.adb.org/news/events/environmental-social-governance-investment-opportunities-risks-asia
Improving Food Safety to Enhance a Country's Social and Economic Well-Being,https://www.adb.org/node/512136
Chikungunya, a risk factor for Guillain-Barré syndrome, Sophie Stegmann-Planchard; Pierre Gallian; Benoit Tressières; Isabelle Leparc-Goffart ; Annie Lannuzel ..., Predictors of Clostridioidesdifficile Infection among Asymptomatic Colonized Patients: A Retrospective Cohort Study, Dominic Poirier, MD, PhD; Philippe Gervais, MD; Margit Fuchs, PhD ; Jean-Francois Roussy, MD; Bianka Paquet-Bolduc, RN, MPA ...
LaBeouf, Rönkkö & Turner, Digital Remix, and Group Authorship, Andrew J Corsa
Homotopy Type Theory and Univalent Foundations,Selected Extended Papers of ITP 2017,The James Construction and $$\pi _4(\mathbb {S}^{3})$$ π 4 ( S 3 ) in Homotopy Type TheoryAbstractIn the first part of this paper we present a formalization in Agda of the James construction in homotopy type theory. We include several fragments of code to show what the Agda code looks like, and we explain several techniques that we used in the formalization. In the second part, we use the James construction to give...
Development of Transfusion Guidelines for Injured Children Using a Modified Delphi Consensus ProcessNo abstract availableIs Early Chemical Thromboprophylaxis in Patients with Solid Organ Injury a Solid Decision?Background The optimal time to initiate chemical thromboprophylaxis (CTP) in patients who have undergone non-operative management (NOM) of blunt solid organ injuries remains controversial. The aim of our study was to assess the impact of early initiation of CTP in patients with blunt abdominal...
Hail suppression effectiveness for varying solubility of natural aerosols in water,Because of a production error, the black line in Figure 13c is incorrect. The correct Figure 13c is shown below.Correction to: Projection of seasonal summer precipitation over Indian sub-continent with a high-resolution AGCM based on the RCP scenariosThe authors want to acknowledge the Korea Meteorological Administration research and Development Program under Grant KMI 2018-07910.Impacts of subgrid-scale orography...
Conserving Functions across Generations: Heredity in Light of Biological Organization, Matteo Mossio; Gaëlle Pontarotti
Pore pressure observation: pressure response of probe penetration and tides,AbstractExcess pore water pressure is an important parameter that can be used to analyze certain physical characteristics of sediment. In this paper, the excess pore water pressure of subseafloor sediment and its variation with tidal movement was measured following the installation of a wharf in Qingdao, China by using a fiber Bragg grating (FBG) piezometer. The results indicated that this FBG piezometer is effective in the...
Education Spillovers in Farm Productivity: Revisiting the Evidence, Véronique Gille, Biased Policy Professionals, Sheheryar Banuri; Stefan Dercon; Varun Gauri
Protective Factors Buffer Life Stress and Behavioral Health Outcomes among High-Risk YouthAbstractThis study investigated internalizing problems, externalizing problems, and polydrug use among African-American youth residing in high-poverty neighborhoods, and tested the potential protective effects of religiosity, parental monitoring, and neighborhood collective efficacy on life stress and behavioral health outcomes (N = 576; 307 females; Mage = 16 years, SD = 1.44 years). A cumulative risk index...
Functional and histological improvements of small nerve neuropathy after high-concentration capsaicin patch application: A case studyIntroduction: Small fiber neuropathy has been found to occur in a large variety of pathological onditions, and the gold standard for diagnosis of small fiber neuropathy is skin biopsy. Sudorimetry is now considered an accurate technique to evaluate small fiber function with a good sensitivity and specificity for the diagnosis of small fiber neuropathy. Capsaicin high-concentration...
School Readiness among U.S. Children: Development of a Pilot MeasureAbstractNo single U.S. data source supports a multidimensional, population-based assessment of young children's readiness to start school. This changed with the 2016 National Survey of Children's Health (NSCH). This study provides an overview of the process by which content related to multiple domains of school readiness was identified, refined and selected for inclusion in the NSCH; describes the analytic processes and resultant...
Delayed hearing loss after microvascular decompression for hemifacial spasm—an unsolved conspiracy of the cochlear apparatus,,How I do it: endoscopic supracerebellar infratentorial approach for torcular meningioma removalAbstractBackgroundTorcular meningioma is a rare type of brain tumor with few reports regarding the appropriate resection approach for this disease. In cases without sinus occlusion, surgeons are advised to spare the sinus; however, the sinus may interfere with the visual field.MethodEndoscopic...
Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass,.Kim-Campbell, Nahmah MD, MS1; Gretchen, Catherine MD1; Ritov, Vladimir B. PhD2; Kochanek, Patrick M. MD, MCCM1,3; Balasubramani, Goundappa K. PhD4; Kenny, Elizabeth BS2; Sharma, Mahesh MD5; Viegas, Melita MD5; Callaway, Clifton MD6; Kagan, Valerian E. PhD2; Bayír, Hülya MD1–3Pediatric Critical Care Medicine: July 11, 2019 - Volume Online First - Issue - pdoi: 10.1097/PCC.0000000000002036Online...
Breaking MPC implementations through compressionAbstractThere are many cryptographic protocols in the literature that are scientifically and mathematically sound. By extension, cryptography today seeks to respond to numerous properties of the communication process beyond confidentiality (secrecy), such as integrity, authenticity, and anonymity. In addition to the theoretical evidence, implementations must be equally secure. Due to the ever-increasing intrusion from governments and other groups, citizens...
Neuroscience, Mindfulness and Holistic Wellness Reflections on Interconnectivity in Teaching and Learning,AbstractNeuroscience offers insight into how we learn. Understanding how to leverage neural development pathways is of interest in teaching because the circuits in the brain respond to effective pedagogical practice; therefore, the role of the teacher is critical. Neuroscientific studies (Damasio in The feeling of what happens: body, emotion and the making of consciousness, Heinemann, London, 1999;...
„Blaue Augen" – Fallbericht über die Risiken von kosmetischen Irisimplantaten,https://link.springer.com/article/10.1007/s00347-018-0792-z?wt_mc=alerts.TOCjournals&utm_source=toc&utm_medium=email&utm_campaign=toc_347_116_7AuthorsAuthors and affiliationsS. Kazerounian1Email authorI. Tsirkinidou1M. Kynigopoulos1M. Müller11.Pallas Klinik ZürichZürichSchweizKasuistikenFirst Online: 10 October 201892DownloadsZusammenfassungEine 24-jährige Iranerin stellte sich mit kosmetischen Irisimplantaten...
Foveale avaskuläre Zone und OCT-Angiographie. Eine Übersicht aktueller Erkenntnisse,https://link.springer.com/article/10.1007/s00347-018-0838-2?wt_mc=alerts.TOCjournals&utm_source=toc&utm_medium=email&utm_campaign=toc_347_116_7AuthorsAuthors and affiliationsN. Mihailovic1Email authorN. Eter1M. Alnawaiseh11.Klinik für AugenheilkundeUniversitätsklinikum MünsterMünsterDeutschlandÜbersichtenFirst Online: 19 December 2018237DownloadsZusammenfassungHintergrundDie foveale avaskuläre Zone (FAZ)...
Macular-Pucker-Chirurgie mit und ohne Delamination der Membrana limitans interna – eine prospektive randomisierte StudieZusammenfassungHintergrundEs gibt Hinweise darauf, dass die zusätzliche Entfernung der ILM (Membrana limitans interna) die Rezidivrate nach Pucker-Chirurgie bei ähnlichem funktionellem Ergebnis reduziert. Andererseits wurden morphologische Veränderungen der inneren Netzhautschichten nach ILM-Peeling beschrieben. Ziel dieser Studie war, die Langzeitdaten nach Vitrektomie mit und...
Critical Care Medicine,Driving Pressure Is Associated with Outcome during Assisted Ventilation in Acute Respiratory Distress SyndromeGiacomo Bellani, M.D., Ph.D.; Alice Grassi, M.D.; Simone Sosio, M.D.; Stefano Gatti, M.D.; Brian P. Kavanagh, M.B.; Antonio Pesenti, M.D.; Giuseppe Foti, M.DAnesthesiology Published online July 12, 2019. doi:10.1097/ALN.0000000000002846Mind to MindDown Under the DeepSonia AroraAnesthesiology Published online July 12, 2019. doi:10.1097/ALN.0000000000002869The Waiting...
Minireview Mini Review The outer membrane glycolipids of bacteria from cold environments: isolation, characterization, and biological activity Angela Casillo; Ermenegilda Parrilli ; Maria Luisa Tutino; Maria Michela Corsaro Review describing peculiar structural features of glycolipids from the outer membrane of Gram-negative psychrophiles and their contribution to cold adaptation. Research Articles Editor's Choice Viral degradation of marine bacterial exopolysaccharides F Lelchat; P Y Mocaer; T...
Editorial Editorial: Microbial food and feed ingredients – reconciling tradition and novelty Egon Bech Hansen; Dennis Sandris Nielsen; Gisèle LaPointe Biotechnology and Synthetic Biology Conserved motifs in the CRISPR leader sequence control spacer acquisition levels in Type I-D CRISPR-Cas systems Sebastian N Kieper ; Cristóbal Almendros; Stan J J Brouns Conserved nucleotide motifs in the CRISPR leader sequence control spacer acquisition levels of CRISPR-Cas systems Environmental Microbiology Brazilian-adapted...
Histogram Analysis Parameters Derived from Conventional T1- and T2-Weighted Images Can Predict Different Histopathological Features Including Expression of Ki67, EGFR, VEGF, HIF-1α, and p53 and Cell Count in Head and Neck Squamous Cell CarcinomaAbstractPurposeTo analyze associations between histogram analysis parameters derived from conventional magnetic resonance imaging (MRI) and different histopathological features in head and neck squamous cell carcinoma (HNSCC).ProceduresThirty-four patients...
Whole Body PET Imaging with a Norepinephrine Transporter Probe 4-[ 18 F]Fluorobenzylguanidine: Biodistribution and Radiation DosimetryAbstractPurpose4-[18F]Fluorobenzylguanidine ([18F]PFBG) is a positron emission tomography (PET) probe for non-invasive targeting of the norepinephrine transporter. The aim of this study was to assess uptake and distribution characteristics of this PET probe.ProceduresThree cynomolgus monkeys were injected with 269 ± 51 MBq (7.3 ± 1.4 mCi) of [18F]PFBG and 21 whole...
Screening of textile finishing agents available on the Chinese market: An important source of per- and polyfluoroalkyl substances to the environmentAbstractOrganofluorinated surfactants are widely employed in textile finishing agents (TFAs) to achieve oil, water, and stain repellency. This has been regarded as an important emission source of per-and polyfluoroalkyl substances (PFASs) to the environment. China is the biggest manufacturer of clothes, and thus TFA production is also a relevant industrial...
Synthesis of silver nanoparticles and its contribution to the capability of Bacillus subtilis to deal with polluted watersAbstractBacillus subtilis widely exists in environment and shows a capability to deal with heavy metals and dyes in polluted waters by adsorption or biological oxidation and reduction. Little is known about the roles of lipopeptides in this capability of B. subtilis. In this study, we found that the lipopeptides produced by B. subtilis could reduce silver ions to silver nanoparticles...
Correction to: Compare two surgical interventions for otitis media with effusion in young childrenIn the original publication, Table 5 and 6 were interchanged by mistake. The correct tables are given here."Barbed snore surgery" simulator: a low-cost surgical modelAbstractBackground"Barbed snore surgery" (BSS) represents one of the last innovation for obstructive sleep apnea syndrome (OSAS) surgical management. Although this technique represents an effective and minimally invasive surgery, it is not...
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