Authors: Zhang J, Tao X, Sun M, Ying R, Su W, Wei W, Meng X Abstract Radiation vasculitis is one of the most common detrimental effects of radiotherapy for malignant tumors. This is developed at the vasculature of adjacent organs. Animal experiments have showed that transplantation of mesenchymal stem cells (MSCs) restores vascular function after irradiation. But the population of MSCs being engrafted into irradiated vessels is too low in the conventional models to make assessment of therapeutic...
05:34
CONCLUSION: miR-16-5p can protect LPS-induced A549 cell injury, and its mechanism may be related to the targeted regulation of CXCR3, which could provide a new target for targeted therapy of lung cancer. PMID: 30957556 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)
02:47
Authors: Aboudara M, Maldonado F Abstract Pleural effusions are a common clinical problem for the primary care physician. Over the past 10 years, there has been a paradigm shift in the field due to emergence of new evidence, which includes the ubiquitous use of thoracic ultrasound, the reemergence of pleuroscopy as a diagnostic and therapeutic modality, the widespread use of indwelling pleural catheters for malignant pleural effusions, and the evidence-based approach to management of complex...
02:41
CONCLUSIONS: Tau inhibited the proliferation and induced the apoptosis of cervical cancer SiHa cells. The MST1 protein plays an important role in the Tau-induced apoptosis of cervical cancer cells. PMID: 30958437 [PubMed - in process] (Source: Chinese Medical Journal)
02:38
Application of robot-assisted laparoscopic pelvic exenteration in treating gynecologic malignancies.
Authors: Yang QY, Tang JY PMID: 30958440 [PubMed - in process] (Source: Chinese Medical Journal)
02:38
CONCLUSIONS: Hyperthermia combined with chemotherapy might lead to the development of better therapeutic strategy for advanced NSCLC with malignant pleural effusion patients. Also, it could greatly reduce the chemotherapy toxic effects in the incidence of weakness and gastrointestinal adverse reactions in advanced NSCLC patients. PMID: 30958433 [PubMed - in process] (Source: Chinese Medical Journal)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
02:38
CONCLUSION: This study revealed high rate of hospitalization of SCD children because of acute painful crisis, ACS, infection, and anemia. These admissions causes could potentially be continuously assessed to minimize the rate of hospitalization. PMID: 30957136 [PubMed - in process] (Source: Saudi Medical Journal)
02:27
Authors: Alsagaby SA, Alhumaydhi FA Abstract Chronic lymphocytic leukemia (CLL) is an incurable malignant disease of B-lymphocytes characterized by drastically heterogeneous clinical courses. Proteomics is an advanced approach that allows a global profiling of protein expression, providing a valuable chance for the discovery of disease-related proteins. In the last 2 decades, several proteomics studies were conducted on CLL to identify aberrant protein expression underpinning the malignant...
02:27
Conclusion: The cognate transcripts of 14 of our CLL-related proteins significantly predicted CLL prognosis. PMID: 30957125 [PubMed - in process] (Source: Saudi Medical Journal)
02:27
CONCLUSIONS: Community-academic partnerships are promising approaches to help address cancer health disparities in African American communities. Factors that influence decision making and participation within partnerships require further research. PMID: 30956251 [PubMed - in process] (Source: Progress in Community Health Partnerships)
00:53
This study demonstrates the formation of a group of novel pH-sensitive and drug-loadable NPs, which provide a simple and efficient drug delivery system for the potential application for cancer treatment.Graphical abstractNovel pH-responsive nanoparticles as promising delivery system were designed and constructed using 2,3-dialdehyde cellulose derivatives. The resulting nanoparticles showed adjustable loading capacity that was tuned by changing the ratio of oleylamine and amino-containing compounds....
00:39
CONCLUSION: The SDGs are a target to call for comprehensive and it should have participatory approaches worldwide. Therefore, Ethiopian government and all policy-makers should be given great attention in order to improve the overall problems in the country. Especially, it requires the knowledge, commitment and responsibilities of politicians, researchers, health professionals and all stakeholders in the country. PMID: 30958340 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Tue Apr 09, 2019 23:16
Publication date: Available online 8 April 2019Source: Actas Urológicas Españolas (English Edition)Author(s): A. Juárez-Soto (Source: Actas Urologicas Espanolas)
Tue Apr 09, 2019 22:43
Publication date: Available online 8 April 2019Source: European UrologyAuthor(s): Ming-Jun Shi, Xiang-Yu Meng, Philippe Lamy, A. Rouf Banday, Jie Yang, Aura Moreno-Vega, Chun-Long Chen, Lars Dyrskjøt, Isabelle Bernard-Pierrot, Ludmila Prokunina-Olsson, François RadvanyiAbstractFGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC → TGC), represents an APOBEC-type motif...
Tue Apr 09, 2019 22:41
Publication date: Available online 8 April 2019Source: European UrologyAuthor(s): Gunnar Steineck, Olof Akre, Anna Bill-Axelson (Source: European Urology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Apr 09, 2019 22:41
ConclusionAKI commonly occurs beyond the perioperative period. Careful risk stratification and modification of risk factors may prevent delayed AKI in patients undergoing colorectal cancer surgery. (Source: The American Journal of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Apr 09, 2019 22:13
Authors: Boan P, Gardam D Abstract Candidemia is a common invasive fungal infection with a high mortality rate. We performed a retrospective audit of candidemia at a tertiary centre in Western Australia, 2005-2014. There were 167 episodes of candidemia due to 173 isolates of Candida. Candida albicans (40.5%), Candida glabrata complex (30.6%), Candida parapsilosis complex (14.4%) were the most common species causing candidemia across the study. Of the tested isolates, 17.7% (11/62) were...
Tue Apr 09, 2019 21:47
CONCLUSION: Proliferation remains one of the most important parameters for tumor characterization helpful in making clinical decisions, but it should be used with great caution. Standardization of the Ki-67 assessment is essential and proliferating index should be expressed as exact numeric value. For patients with proliferative index near the cut-off value, other factors must be considered in making clinical decisions. PMID: 30958325 [PubMed - as supplied by publisher] (Source: Breast Disease)
Tue Apr 09, 2019 21:44
CONCLUSION: Results provide the initial evidence of the expression of survivin mRNA in breast cancer patients in Vietnam, suggesting the role of survivin mRNA in breast cancer molecular pathology. PMID: 30958326 [PubMed - as supplied by publisher] (Source: Breast Disease)
Tue Apr 09, 2019 21:44
CONCLUSIONS: The results indicated that there is a need for a structured educational program to improve oncology nurses knowledge regarding BCRL. PMID: 30958327 [PubMed - as supplied by publisher] (Source: Breast Disease)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Apr 09, 2019 21:44
ConclusionsThe realized gains in patient flow rate were lower than expected based on scan times (65%) because of increased technologist activity time for the AB-MR protocol. (Source: Journal of the American College of Radiology)
Tue Apr 09, 2019 21:37
Objectives Multimodality reporter gene imaging provides valuable, noninvasive information on the fate of engineered cell populations. To complement magnetic resonance imaging (MRI) measures of tumor volume and 2-dimensional reporter-based optical measures of cell viability, reporter-based MRI may offer 3-dimensional information on the distribution of viable cancer cells in deep tissues. Materials and Methods Here, we engineered human and murine triple-negative breast cancer cells with lentivirus...
Tue Apr 09, 2019 21:35
Objectives The aim of this study was to evaluate breast multiparametric ultrasound (mpUS) and its potential to reduce unnecessary breast biopsies with 1, 2, or 3 additional quantitative parameters (Doppler, elastography, and contrast-enhanced ultrasound [CEUS]) to B-mode and investigate possible variations with different reader experience. Materials and Methods This prospective study included 124 women (age range, 18–82 years; mean, 52 years), each with 1 new breast lesion, scheduled for ultrasound-guided...
Tue Apr 09, 2019 21:35
Objectives The aim of this study was to investigate the feasibility of using low-dose perfusion computed tomography (CT) in breast cancers for quantification of tumor vascularity and to correlate perfusion indexes with prognostic biomarkers. Materials and Methods This preliminary study was approved by our institutional review board. Signed informed consent was obtained from all 70 enrolled patients with invasive breast cancers. Low-dose perfusion CT was performed with the patient in the prone...
Tue Apr 09, 2019 21:35
We report the case of a 54-year-old man with 6 months of progressive sacral pain. Computed tomography showed a large osteolytic mass in the sacrum with multiple osteolytic foci in the ilium and lumbar spine. Magnetic resonance imaging revealed multiple fluid-fluid levels in the sacral lesion as well as in the lumbar foci. The multiple bone les ions were initially diagnosed as a primary sacral malignancy with multiple bone metastases. A biopsy of the sacral lesion under the guidance of computed tomography...
Tue Apr 09, 2019 21:35
ConclusionWhole-body CT provides important information for disease monitoring and detection of incidental findings, thereby improving the management of patients with MM. (Source: Skeletal Radiology)
Tue Apr 09, 2019 21:35
In this study, we evaluated the effect of valspodar and cisplatin co-treatment on cell viability, cell death and oxidative status in ovarian cancer cells. The two cisplatin-resistant human ovarian cancer cell lines SK-OV-3 and MDAH-2774 were treated with cisplatin, valspodar, or cisplatin+valspodar for 24 and 48 hours. Untreated cells were used as control group. Cell viability was evaluated by MTT assay. Cell death was assessed by TUNEL and comet assay. Lipid peroxidation (malondialdehyde) and protein...
Tue Apr 09, 2019 21:19
In this study, we report a case of an 81-year-old male, presenting with gross hematuria and acute urinary retention, which was subsequently diagnosed with CCUC at our pathology department. Furthermore, we provide a short systematic review of the literature (PubMed, Scopus, Science Citation Index) for this rare histopathological entity and a brief discussion about its morphological and immunohistochemical (IHC) characteristics. PMID: 30957722 [PubMed - as supplied by publisher] (Source: Bosnian...
Tue Apr 09, 2019 21:19
Authors: Baroš IV, Tanasković N, Pellas U, Eri Ž, Tadić Latinović L, Tot T Abstract Determination of human epidermal growth factor receptor 2 (HER2) status is important for adequate treatment of breast cancer (BC) patients. The novel HER2 gene protein assay (GPA) is particularly convenient, as it allows the simultaneous assessment of HER2 protein expression and gene amplification at individual cell level. Here we investigated the frequency of internodal HER2 heterogeneity in axillary lymph...
Tue Apr 09, 2019 21:19
35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2019/04/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Tue Apr 09, 2019 20:41
This article reviews the broad range of types of occupational lung diseases, including airways disease, pneumoconioses, and cancer. Common causes of occupational lung disease are reviewed with specific examples and clinical features. Emphasis on the importance of a detailed history to make an accurate diagnosis of an occupational lung disease is discussed. PMID: 30955520 [PubMed - in process] (Source: Clinical Lung Cancer)
Tue Apr 09, 2019 19:13
This article provides a broad overview of the field to serve as a resource for primary care physicians. PMID: 30955509 [PubMed - in process] (Source: Clinical Lung Cancer)
Tue Apr 09, 2019 19:13
Authors: Nasim F, Sabath BF, Eapen GA Abstract Lung cancer is the world's leading cause of cancer death. Screening for lung cancer by low-dose computed tomography improves mortality. Various modalities exist for diagnosis and staging. Treatment is determined by subtype and stage of cancer; there are several personalized therapies that did not exist just a few years ago. Caring for the patient with lung cancer is a complex task. This review provides a broad outline of this disease, helping...
Tue Apr 09, 2019 19:13
This randomized clinical trial compares the effects of vitamin D supplementation vs placebo on 5-year relapse-free survival after surgical resection of stage I-III esophageal, gastric, small bowel, and colorectal cancers. (Source: JAMA)
Tue Apr 09, 2019 02:00
In this narrative medicine essay, a palliative care physician with breast cancer talks about the end-of-life conversations she and her husband have, recalling how her priorities have changed through life stages and how she uses her experiences to inform her interactions with her own cancer patients. (Source: JAMA)
Tue Apr 09, 2019 02:00
Over the past 30 years, extensive research has explored the use of nutritional supplements for prevention of cancer. Despite what appears to be strong observational evidence, randomized clinical trials of beta carotene, ascorbic acid, alpha tocopherol, selenium, and folic acid all failed to show evidence of efficacy for cancer chemoprevention. The colorectum has been particularly well studied: trials of these interventions examining adenoma recurrence have been uniformly negative as well. (Source:...
Tue Apr 09, 2019 02:00
This cancer epidemiology study links electronic health record (EHR) data with comprehensive genomic profiling to identify patient characteristics and gene alterations associated with overall survival, response to targeted and immune therapies, and other clinical outcomes in patients non –small cell lung cancer (NSCLC). (Source: JAMA)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Apr 09, 2019 02:00
This phase 2 randomized clinical trial compares the effects of high-dose vs standard-dose vitamin D3 added to standard chemotherapy on progression-free survival among patients with metastatic colorectal cancer. (Source: JAMA)
Tue Apr 09, 2019 02:00
In conclusion, MPT0G413 and BTZ synergistically inhibit MM viability, providing a framework for the clinical evaluation of combined therapies for MM. Introduction Multiple myeloma (MM) is a B cell malignancy characterized by the proliferation of bone marrow (BM) plasma cells and the production of large amounts of abnormal immunoglobulins (1) In the United States, it was estimated that 30,770 new MM cases would be diagnosed in 2018, accounting for 1.8% of newly diagnosed cancer cases (2)....
Tue Apr 09, 2019 00:00
AbstractDysgeusia and nausea are common side effects observed in head and neck cancer patients treated with either exclusive radiotherapy or combined modality treatment. The aim of the present study was to prospectively evaluate dysgeusia, during treatment and follow-up, using the chemotherapy-induced taste alteration scale (CiTAS), a metrics based on 18-items exploring three dimensions (quantitative and qualitative changes in taste perception, anddiet-related issues) identified through a four-factor...
Tue Apr 09, 2019 00:00
Publication date: Available online 8 April 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Khuzema Saifuddin Fatehi, Shivakumar Thiagarajan (Source: British Journal of Oral and Maxillofacial Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Apr 09, 2019 18:36
We report a 62-year-old woman who presented with pain caused by bony metastases as the first symptom eight years after being diagnosed with submandibular ACC. Although such cases are rare, they indicate that when patients who have had cancer visit the hospital with other symptoms, clinicians should make sure to rule out metastasis. (Source: British Journal of Oral and Maxillofacial Surgery)
Tue Apr 09, 2019 18:36
Publication date: Available online 8 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Benjamin J. Drapkin, Anna F. FaragoDNA damage repair (DDR) inhibition and immune checkpoint blockade (ICB) have each individually shown modest clinical activity in small cell lung cancer (SCLC). Recently, Sen and colleagues (Cancer Discov. 2019;https://doi.org/10.1158/2159-8290.CD-18-1020) demonstrated that DDR inhibition can activate the stimulator of interferon genes (STING) innate immune pathway,...
Tue Apr 09, 2019 18:07
Publication date: Available online 8 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Pawan Noel, Daniel D. Von Hoff, Ashok K. Saluja, Mohana Velagapudi, Erkut Borazanci, Haiyong HanTriptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor, immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor solubility, bioavailability, and toxicity. Recently, Minnelide, a water-soluble prodrug of triptolide, was shown to have...
Tue Apr 09, 2019 18:07
Publication date: Available online 8 April 2019Source: Pharmacology & TherapeuticsAuthor(s): Yi Zhu, Jiaqi Liu, Joun Park, Priyamvada Rai, R. Grace ZhaiAbstractNicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many critical processes. Its role as both a driver of energy production and a signaling molecule underscores its importance in health and disease. NAD+ signaling impacts multiple processes that are dysregulated in cancer, including DNA repair, cell proliferation,...
Tue Apr 09, 2019 18:07
Publication date: Available online 8 April 2019Source: Pharmacological ResearchAuthor(s): Chunli Wei, Xiaojun Yao, Zebo Jiang, Yuwei Wang, Dianzheng Zhang, Xi Chen, Xingxing Fan, Chun Xie, Jingliang Cheng, Junjiang Fu, Elaine Lai-Han LeungAbstractLung cancer is the most commonly diagnosed cancer worldwide and it is also the most leading cause of cancer-related deaths. Although multiple generations of targeted therapeutic drugs such as gefitinib and afatinib specifically targeting the epidermal growth...
Tue Apr 09, 2019 18:07
This study was geared towards assessing the possible antioxidant, enzyme inhibitory, and cytotoxic activities of ethyl acetate, methanol, and water extracts of Sideritis ozturkii Aytaç & Aksoy. The phytochemical profiles of the studied extracts were characterised by HPLC-MS/MS. The methanol extract, rich in phenolics (78.04 mg gallic acid equivalent/g), exhibited the strongest antioxidant activities. However, the ethyl acetate extract was the most active extract in the enzyme inhibitory assays....
Tue Apr 09, 2019 18:07
ConclusionFEJ has the hematopoietic effect in chemotherapy-induced myelosuppression mice. It might be achieved by improving the proliferative capacity of HSCs and the differentiation ability of HPCs. The molecular mode of action of FEJ might be the improvement of the bone marrow microenvironment via ECM-receptor interaction, the promoted proliferation of HSC through regulation of PI3K-AKT signaling pathway, and the involvement of osteoblasts and osteoclasts. MMP2 and COL1A1 appear to be the key relevant...
Tue Apr 09, 2019 18:07
ConclusionOur results strongly suggest that the components of the natural plant protoberberine fraction (BBR-F) extracted from C. majus may represent promising novel photosensitive agents and can be applied in cancer photodynamic therapy as natural photosensitizers.Graphical abstract (Source: Phytomedicine)
Tue Apr 09, 2019 18:06
NOD-like receptor signaling in inflammation-associated cancers: from functions to targeted therapies
ConclusionIn this review, we discuss how NLR signaling is involved in inflammation-associated cancers, and highlight the NLR-targeted botanicals and synthetic small molecules in cancer intervention.Graphical Abstract (Source: Phytomedicine)
Tue Apr 09, 2019 18:06
CONCLUSION: Women with a history of thyroid cancer have similar pregnancy outcomes and offspring growth to those with no such history. PMID: 30957663 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Apr 09, 2019 17:50
CONCLUSIONS: Our data identify rare germline variants that may play important roles in NMTC predisposition. We propose that in future research including functional characterization, these variants and genes be considered primary candidates for thyroid cancer predisposition. PMID: 30957677 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Tue Apr 09, 2019 17:50
Actinic cheilitis (AC) is a variant of actinic keratosis which is known to be a premalignant condition that could develop into squamous cell carcinoma (SCC). Epimyoepithelial carcinoma (EC) is a very rare sali... (Source: Maxillofacial Plastic and Reconstructive Surgery)
Tue Apr 09, 2019 02:00
MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages, Published online: 09 April 2019; doi:10.1038/s41388-019-0811-9MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages (Source: Oncogene)
Tue Apr 09, 2019 00:00
AbstractObesity is a risk factor for all major gastrointestinal cancers. With the rapid increase in the prevalence of obesity worldwide, this link could lead to an elevated burden of cancers of the digestive system. Currently, three main mechanisms explaining the link between excess adiposity and gastrointestinal cancer risk are being considered, including altered insulin signaling, obesity-associated chronic low-grade inflammation, and altered sex hormone metabolism, although new potential mechanisms...
Tue Apr 09, 2019 00:00
ConclusionAt the local tumor site, mature LAMP-3 DCs might be associated with increasing tumor infiltrating CD8 T cells. (Source: Esophagus)
Tue Apr 09, 2019 00:00
Thyroid, Ahead of Print. (Source: Thyroid)
Tue Apr 09, 2019 00:00
Corrigendum: Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status Yu-Tang Chin1,2†, Zong-Rong He3,4†, Chi-Long Chen5†, Hsiao-Ching Chu6, Yih Ho1,7, Po-Yu Su8, Yu-Chen S. H. Yang9, Kuan Wang1,8, Ya-Jung Shih1,8, Yi-Ru Chen1,8, Jens Z. Pedersen10, Sandra Incerpi11, André Wendindondé Nana12, Heng-Yuan Tang13, Hung-Yun Lin1,12,13,14,15*, Shaker A. Mousa13, Paul J. Davis13,16 and Jacqueline Whang-Peng1,2,12* 1Taipei Cancer Center, Taipei Medical...
Tue Apr 09, 2019 00:00
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of...
Tue Apr 09, 2019 00:00
In conclusion, both T3 and T2 are capable of inducing protective effects against mtDNA oxidative stress, but they affect different pathways. In the present study, we did not investigate the possible involvement of other homeostatic mechanisms possibly counteracting the oxidative stress, such as autophagy. However, this aspect has been recently investigated by Iannucci et al. (29), demonstrating that in the liver of HFD-treated rats, the administration of either T3 or T2 affected the autophagy mechanisms,...
Tue Apr 09, 2019 00:00
Discussion: Our results demonstrated that circSMARCA5 was decreased and exerted tumor-suppressive effects in GC. circSMARCA5 can function as a potential biomarker for GC prognosis and diagnosis. PMID: 30956729 [PubMed - in process] (Source: Disease Markers)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Apr 09, 2019 17:16
In this study, we aimed to analyze the mRNA and protein expression levels of LTBP2 in CRC tissues and then estimate their values as a potential prognostic biomarker. We detected the mRNA expression of LTBP2 in 28 cases of fresh CRC tissues and 4 CRC cell lines and the protein expression of LTBP2 in 483 samples of CRC tissues, matched tumor-adjacent tissues, and benign colorectal diseases. LTBP2 protein expression was then correlated to patients' clinical features and overall survival. Both LTBP2...
Tue Apr 09, 2019 17:16
Publication date: Available online 8 April 2019Source: Cancer CellAuthor(s): María Teresa Blasco, Carolina Navas, Guillermo Martín-Serrano, Osvaldo Graña-Castro, Carmen G. Lechuga, Laura Martín-Díaz, Magdolna Djurec, Jing Li, Lucia Morales-Cacho, Laura Esteban-Burgos, Javier Perales-Patón, Emilie Bousquet-Mur, Eva Castellano, Harrys K.C. Jacob, Lavinia Cabras, Monica Musteanu, Matthias Drosten, Sagrario Ortega, Francisca Mulero, Bruno SainzSummaryFive-year survival for pancreatic ductal adenocarcinoma...
Tue Apr 09, 2019 17:02
Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness, Published online: 09 April 2019; doi:10.1038/s41388-019-0809-3Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness (Source: Oncogene)
Tue Apr 09, 2019 00:00
Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation, Published online: 09 April 2019; doi:10.1038/s41388-019-0813-7Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation (Source: Oncogene)
Tue Apr 09, 2019 00:00
Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation, Published online: 09 April 2019; doi:10.1038/s41388-019-0798-2Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation (Source: Oncogene)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Apr 09, 2019 00:00
NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer, Published online: 09 April 2019; doi:10.1038/s41388-019-0806-6NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer (Source: Oncogene)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Apr 09, 2019 00:00
The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition, Published online: 09 April 2019; doi:10.1038/s41388-019-0802-xThe anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition (Source: Oncogene)
Tue Apr 09, 2019 00:00
In this study we revealed functional expression of Ca2+-permeable NMDARs in three glioblastoma cell lines. Therefore, we investigated the impact of this receptor on cell survival, migration and DNA double-strand break (DSB) repair in the presence of both, glutamate and NMDAR antagonists, and after clinically relevant doses of ionizing radiation. Our results indicate that treatment with NMDAR antagonists slowed the growth and migration of glutamate-releasing LN229 cells, suggesting that activation...
Tue Apr 09, 2019 00:00
ConclusionsC-ion RT for LN oligo-recurrence appeared to be effective and safe. C-ion RT may provide a survival benefit to patients with LN oligo-recurrence, particularly to those with few LN metastases, smaller LN diameters, and longer disease-free intervals. (Source: International Journal of Clinical Oncology)
Tue Apr 09, 2019 00:00
There was a typo in author Andrew Wahba 's name in the initial online publication. The original article has been corrected. (Source: Journal of Neuro-Oncology)
Tue Apr 09, 2019 00:00
Conclusion: Patients receiving FOLFOX have lower BM tolerance to CRT than those receiving 5FU. Low-dose radiation to the PBM is predictive for HT2+ in patients who received 5FU. NTCP modeling in FOLFOX group predicts much higher risk of HT3+ than 5FU group. Introduction Rectal cancer is a common malignancy in the world (1). Several randomized trials have demonstrated that preoperative radiotherapy (RT) combined fluorouracil (FU)-based chemotherapy improves locoregional control (LRC) in patients...
Tue Apr 09, 2019 00:00
In conclusion, the high structural diversity of these compounds pinpoints the significant range of inhibition strategies that can be conceived to target the class I methyltransferases. Although the structural details of the various members of this family are unique, the success stories of drug design for several enzymes belonging to this family portends the likely achievement of discovering potent and selective inhibitors of METTL3/METTL14. Author Contributions AF and AP wrote the manuscript. ZI...
Tue Apr 09, 2019 00:00
Conclusions: The performance of AS AC generally increased as the population of the atlas library increased. However, the performance does not drastically vary in the larger atlas libraries in contrast to the logic that bigger atlas library should lead to better results. In fact, the results do not vary significantly toward the larger atlas library. It is necessary for the institutions to independently research the optimal number of subjects. Introduction Manual contouring of target and critical...
Tue Apr 09, 2019 00:00
Conclusions: Radiomic signature and radiomic nomogram may be low-cost, non-invasive means for successfully predicting risk for postoperative advanced HGSOC recurrence before or during the perioperative period. Radiomic signature is a potential prognostic marker that may allow for individualized evaluation of patients with advanced HGSOC. Introduction Ovarian cancer is the leading cause of gynecological cancer-related deaths (1). Seventy percent of these deaths are due to high-grade serous ovarian...
Tue Apr 09, 2019 00:00
Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness, Published online: 09 April 2019; doi:10.1038/s41388-019-0804-8Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness (Source: Oncogene)
Tue Apr 09, 2019 00:00
Authors: Lucarelli G, Loizzo D, Ferro M, Rutigliano M, Vartolomei MD, Cantiello F, Buonerba C, Di Lorenzo G, Terracciano D, De Cobelli O, Bettocchi C, Ditonno P, Battaglia M Abstract INTRODUCTION: An altered metabolic regulation is involved in the development and progression of different cancer types. As well as this, many genes associated with tumors are shown to have an important role in control of the metabolism. The incidence of prostate cancer (PCa) is increased in men with metabolic...
Tue Apr 09, 2019 16:37
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