Genes, Genomes, Genetics

Presence of Newcastle disease viruses of sub-genotypes Vc and VIn in backyard chickens and in apparently healthy wild birds from Mexico in 2017

Abstract Virulent Newcastle disease viruses (NDV) have been present in Mexico since 1946, and recently, multiple outbreaks have been reported in the country. Here, we characterized eleven NDV isolated from apparently healthy wild birds and backyard chickens in three different locations of Jalisco, Mexico in 2017. Total RNA from NDV was reverse-transcribed, and 1285 nucleotides, which includes 3/4 of the fusion gene, was amplified and sequenced using a long-read MinION sequencing...

Latest Results for Virus Genes

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Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection

by Tiffany Hensley-McBain, Michael C. Wu, Jennifer A. Manuzak, Ryan K. Cheu, Andrew Gustin, Connor B. Driscoll, Alexander S. Zevin, Charlene J. Miller, Ernesto Coronado, Elise Smith, Jean Chang, Michael Gale Jr., Ma Somsouk, Adam D. Burgener, Peter W. Hunt, Thomas J. Hope, Ann C. Collier, Nichole R. Klatt Gastrointestinal (GI) mucosal dysfunction predicts and likely contributes to non-infectious comorbidities and mortality in HIV infection and persists despite antiretroviral therapy. However,...

PLOS Pathogens: New Articles

Thu Apr 11, 2019 22:00

T-cell derived acetylcholine aids host defenses during enteric bacterial infection with <i>Citrobacter rodentium</i>

by Valerie T. Ramirez, Dayn Romero Godinez, Ingrid Brust-Mascher, Eric B. Nonnecke, Patricia A. Castillo, Mariana Barboza Gardner, Diane Tu, Jessica A. Sladek, Elaine Nicole Miller, Carlito B. Lebrilla, Charles L. Bevins, Melanie G. Gareau, Colin Reardon The regulation of mucosal immune function is critical to host protection from enteric pathogens but is incompletely understood. The nervous system and the neurotransmitter acetylcholine play an integral part in host defense against enteric bacterial...

PLOS Pathogens: New Articles

Thu Apr 11, 2019 21:09

FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells

by Amanda J. Audesse, Shleshma Dhakal, Lexi-Amber Hassell, Zachary Gardell, Yuliya Nemtsova, Ashley E. Webb Maintenance of a healthy proteome is essential for cellular homeostasis and loss of proteostasis is associated with tissue dysfunction and neurodegenerative disease. The mechanisms that support proteostasis in healthy cells and how they become defective during aging or in disease states are not fully understood. Here, we investigate the transcriptional programs that are essential for neural...

PLoS Genetics: New Articles

Thu Apr 11, 2019 21:09

Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

by Boxun Zhao, Qixi Wu, Adam Yongxin Ye, Jing Guo, Xianing Zheng, Xiaoxu Yang, Linlin Yan, Qing-Rong Liu, Thomas M. Hyde, Liping Wei, August Yue Huang Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic mosaicism in the brain and other somatic tissues of an individual. However, the genomic distribution of somatic human-specific LINE-1 (L1Hs) insertions and their potential impact on carrier cells...

PLoS Genetics: New Articles

Thu Apr 11, 2019 21:09

Genes, Vol. 10, Pages 296: Brassica napus Infected with Leptosphaeria maculans

Genes, Vol. 10, Pages 296: Brassica napus Infected with Leptosphaeria maculans Genes doi: 10.3390/genes10040296 Authors: Ma Wei Lin Zhang Sun Yang Lu Li Alternative splicing (AS) is a post-transcriptional regulatory process that enhances transcriptome diversity, thereby affecting plant growth, development, and stress responses. To identify the new transcripts and changes in the isoform-level AS landscape of rapeseed (Brassica napus) infected with the fungal...

Genes

Thu Apr 11, 2019 03:00

Genes, Vol. 10, Pages 295: A Systematically Assembled Signature of Genes to be Deep-Sequenced for Their Associations with the Blood Pressure Response to Exercise

Genes, Vol. 10, Pages 295: A Systematically Assembled Signature of Genes to be Deep-Sequenced for Their Associations with the Blood Pressure Response to Exercise Genes doi: 10.3390/genes10040295 Authors: Pescatello Parducci Livingston Taylor : Background: Exercise is one of the best nonpharmacologic therapies to treat hypertension. The blood pressure (BP) response to exercise is heritable. Yet, the genetic basis for the antihypertensive effects of exercise remains elusive....

Genes

Thu Apr 11, 2019 03:00

Mutation spectrum and pivotal features for differential diagnosis of Mucopolysaccharidosis IVA patients with severe and attenuated phenotype

Publication date: Available online 11 April 2019Source: GeneAuthor(s): Beyhan Tüysüz, Dilek Uludağ Alkaya, Güven Toksoy, Nilay Güneş, Timur Yıldırım, İlhan Avni Bayhan, Zehra Oya UygunerAbstractMucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disease caused by biallelic mutations in GALNS gene and characterized by progressive skeletal deformities with short stature. The aim of this study was to evaluate the genotype, longitudinal height measurement and clinical features of MPS IVA patients....

Gene

Thu Apr 11, 2019 12:38

The Yin and Yang of cancer genes

Publication date: Available online 11 April 2019Source: GeneAuthor(s): Murali Dharan Bashyam, Srinivas Animireddy, Pratyusha Bala, Ashmala Naz, Sara Anisa GeorgeAbstractCancer is caused by malfunctioning of genes that normally regulate cardinal processes including various nuclear functions, cell division and survival, cell surface to nucleus signaling cascades, etc. Cancer associated genes are often classified as oncogenes (OCGs) or tumor suppressor genes (TSGs) depending on whether they promote...

Gene

Thu Apr 11, 2019 12:38

Towards Spider Glue: Long Read Scaffolding for Extreme Length and Repetitious Silk Family Genes AgSp1 and AgSp2 with Insights into Functional Adaptation

An individual orb weaving spider can spin up to seven different types of silk, each with unique functions and material properties. The capture spiral silk of classic two-dimensional aerial orb webs is coated with an amorphous glue that functions to retain prey that get caught in a web. This unique modified silk is partially comprised of spidroins (spider fibroins) encoded by two members of the silk gene family. The glue differs from solid silk fibers as it is a viscoelastic, amorphic, wet material...

G3: .Genes, Genomes, Genetics Mission - Online First Articles

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An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry

Septins regulate the organization of the actin cytoskeleton, vesicle transport and fusion, chromosome alignment- and segregation, and cytokinesis in mammalian cells. SEPT9 is part of the core septin hetero-octamer in human cells which is composed of SEPT2, SEPT6, SEPT7, and SEPT9. SEPT9 has been linked to a variety of intracellular functions as well as to diseases and diverse types of cancer. A targeted high-throughput approach that aims at systematically deciphering the interaction partners of SEPT9...

G3: .Genes, Genomes, Genetics Mission - Online First Articles

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Bmp signaling in molar cusp formation

Publication date: Available online 11 April 2019Source: Gene Expression PatternsAuthor(s): Fumiya Meguro, Thantrira Porntaveetus, Maiko Kawasaki, Katsushige Kawasaki, Akane Yamada, Yoshito Kakihara, Makio Saeki, Koichi Tabeta, John A. Kessler, Takeyasu Maeda, Atsushi OhazamaAbstractTooth cusp is a crucial structure, since the shape of the molar tooth is determined by number, shape, and size of the cusp. Bone morphogenetic protein (Bmp) signaling is known to play a critical role in tooth development,...

Gene Expression Patterns

Thu Apr 11, 2019 14:16