The immune functions of proprotein convertase subtilisin/kexin type 9 (PCSK9): Local and systemic perspectives. PCSK9 as a secreted protein has both local and systemic effects on cellular function.AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low‐density lipoprotein receptor (LDLR) to trigger endocytosis and lysosome degradation in hepatocytes, regulating intracellular and plasma cholesterol levels. The discovery of PCSK9 has provided a new target for the management...
Thu Apr 04, 2019 19:33
1.A long noncoding RNA–microRNA–messenger RNA network related to epithelial ovarian cancer (EOC) cisplatin‐resistant was established.2.Genes involved in EOC cisplatin‐resistant were identified.AbstractTo construct a long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger RNA (mRNA) regulatory network related to epithelial ovarian cancer (EOC) cisplatin‐resistant, differentially expressed genes (DEGs), differentially expressed lncRNAs (DELs), and differentially expressed miRNAs (DEMs) between...
Thu Apr 04, 2019 19:33
This study analyzed a strontium substituted ß‐tricalcium phosphate (Sr‐ßTCP) associated to syngeneic, unexpanded, and undifferentiated mesenchymal stem cells from bone marrow (BMSC) or adipose tissue (ADSC) as a new tissue engineering approach for spinal fusion procedures. Results suggest that addition of BMSCs to a Sr‐ßTCP improve bone formation and fusion, both in osteoporotic and nonosteoporotic animal, whereas spinal fusion is not enhanced in rats treated with Sr‐ßTCP + ADSCs. For conducting...
Thu Apr 04, 2019 19:33
Pretreatment prognostic nutritional index was associated with tumor stage and lymph nodes metastases and was an independent prognostic factor in esophageal cancer.AbstractClinicopathological characteristics and prognosis of esophageal cancer (EC) patients with decreased prognostic nutritional index (PNI) have not been well investigated. So, we conducted this meta‐analysis. We performed comprehensive research in PubMed, Embase, and Cochrane databases. The effect size was hazard ratio (HR)...
Thu Apr 04, 2019 19:33
We found that tumor necrosis factor α (TNF‐α) is produced and released in granulosa cells (GCs) before the ovulation. Given the TNF‐α levels in serum and follicular fluid (FF), it is obvious that follicles are one of the main sources of TNF‐α and one of the contributors to the level of TNF‐α in serum during follicular development. Besides, we showed that TNF‐α level in serum and FF could be a potential marker for ovarian response in assisted reproductive techniques treatment.AbstractTo...
Thu Apr 04, 2019 19:32
We found that inhibition of nuclear enriched abundant transcript 1 (NEAT1) repressed myocardial ischemia‐reperfusion injury via inactivating p38 mitogen‐activated protein kinase (MAPK) signaling. Our data revealed that NEAT1 Downregulation inhibited myocardial IR injury via inactivating MAPK pathway.AbstractMyocardial ischemia‐reperfusion (IR) injury is a common cardiovascular problem, which remains a major cause of death in the world. Emerging evidence has suggested that long noncoding RNAs...
Thu Apr 04, 2019 19:32
The stem cell transcription factor Sox2 is widely recognized for its many roles during normal development and cancer. The work described in this review indicates that the dosage of Sox2 influences cell fate decisions made during normal mammalian development, as well as cell fate decisions in cancer, including those that influence the tumor cell of origin and progression of the cancer. Equally important, Sox2 dosage is a key determinant in the proliferation of both normal cells and tumor cells,...
Thu Apr 04, 2019 19:32
On the basis of the analysis of 1,016 breast cancer (BRCA) transcriptome expression profiles, our study strongly suggest that protein‐coding gene (PCG)‐long noncoding RNA (lncRNA) signature may serve as a novel biomarker for predicting prognosis of patients with BRCA including triple negative type patients.AbstractIntegrating protein‐coding gene (PCG) with long noncoding RNA (lncRNA) expression profiles, our aim is to identify a multidimensional transcriptome model that can predict individual...
Thu Apr 04, 2019 19:31
This is the first report about the solute carrier family 38 member 1 (SLC38A1) expression with the outcome of acute myeloid leukemia (AML) patients. The results confirmed that the high expression of SLC38A1 was an adverse prognostic indicator for AML.AbstractThe glutamine amino acid transporter solute carrier family 38 member 1 (SLC38A1) is associated with the occurrence and progression of solid tumors. However, it has not yet been assessed in patients with hematologic malignancy. Herein,...
Thu Apr 04, 2019 19:31
In this study, we reveal that microtubule reorganization is critical for microtubule clearance and nuclear extrusion during erythropoiesis. Although disruption of microtubule dynamics does not affect the efficiency of erythroblast enucleation, microtubule stabilizers suppress microtubule clearance in mature erythrocytes, whereas microtubule destabilizers lead to atypical partitioning of microtubules, indicative of a defect in nuclear partitioning.AbstractMammalian erythrocytes are highly...
Thu Apr 04, 2019 19:31
Here, our aim was to review the biological and pharmacological activity of demethoxycurcumin relevant to the treatment of noncancerous diseases.AbstractTurmeric extracts contain three primary compounds, which are commonly referred to as curcuminoids. They are curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin. While curcumin has been the most extensively studied of the curcuminoids, it suffers from low overall oral bioavailability due to extremely low absorption as a result of low...
Thu Apr 04, 2019 19:30
Comprehensive bioinformatics methods were applied in our study to analyze the functional enrichment and pathways of the differentially expressed genes in benign prostatic hyperplasia (BPH). Focal adhesion pathway, FoxO signaling pathway, and autophagy pathway may be crucial for the progress of BPH. Ubiquitin‐conjugating enzyme E2 C (UBE2C), serine/threonine kinase (AKT1), mitogen‐activated protein kinase 1 (MAPK1), cyclin B1 (CCNB1), polo‐like kinase 1 (PLK1) may be the key genes that play...
Thu Apr 04, 2019 19:29
The potential roles of the miR‐29 family in the modulation of several human cancers development and progression. This miR family has been studied as the clinical marker for the diagnosis and prognosis of many cancers as well as the potential targets to prevent and treat cancers. Regulating the expression of the miR‐29 family in a variety of cancers can be a new strategy to obtain better results for cancer patients' treatment in the future.AbstractmiR‐29 family is one of the small noncoding...
Thu Apr 04, 2019 19:29
Brefeldin A (BFA) is a fungal metabolite that could block protein transport from the endoplasmic reticulum to Golgi complex. We find that exposure to BFA in porcine oocytes compromises the meiotic maturation via disrupting the organelle assembly and dynamics. Our findings not only discover the role of Golgi‐mediated protein transport during oocyte meiotic maturation but also extend our understanding of the molecular mechanisms underlying the oocyte meiotic failure that frequently occurs in...
Thu Apr 04, 2019 19:28
Combining computational approaches, we enriched miRNA binding motifs of the Wnt pathway associated with upregulated genes that miR‐381 targets main genes of the Wnt signaling pathway including CTNNB1, RhoA, ROCK1, and c‐MYC genes.In a mouse model of TNBC, miR‐381 re‐expression inhibited the invasion of cancer cells to lung and liver and prolonged the survival time of cancer cell‐bearing mice.AbstractTriple‐negative breast cancer, devoid of estrogen (ER), progesterone (PR), and human epidermal...
Wed Apr 03, 2019 20:07
The development of an efficient in vitro 3D brain cancer system by using Ca‐alginate scaffolds. This structure mimicked the brain tumor microenvironment with high cell viability and proliferation, as well as retained cancer stem cell property. This system could serve as a platform for anticancer agent screening.AbstractThe three‐dimensional (3D) cell culture model has been increasingly used to study cancer biology and screen for anticancer agents due to its close mimicry to in vivo tumor...
Wed Apr 03, 2019 20:07
Blockage of PI3K suppressed this signaling in Treg, rebalanced Th1/Treg, inhibited the production of inflammatory cytokines, and enhanced Treg's function in sarcoidosis. PI3K/Akt signaling plays an important role in regulating Th1/Th2 rebalances and it is critical for the optimal Treg responses in pulmonary sarcoidosis.AbstractSarcoidosis is a systemic granulomatous disease associated with Th1/ regulatory T cells (Treg) paradigm. PI3K/Akt signaling, critical for maintaining Treg's homeostasis,...
Wed Apr 03, 2019 20:06
Nod‐like receptor C5 (NLRC5) negatively regulates the level of Toll‐like receptor 2 (TLR2)‐dependent inflammatory responses and the activation of nuclear factor‐κB, whereas NLRC5 does not influence the expression of TLR2 protein.AbstractNLRC5, the largest member of the Nod‐like receptor (NLR) family, has been reported to play a pivotal role in regulating inflammatory responses. Recent evidence suggests that NLRC5 participates in Toll‐like receptor (TLR) signaling pathways and negatively...
Wed Apr 03, 2019 20:06
Our study first demonstrates that OGD‐induced HMEC‐1 cell injury was alleviated by CXCL16 targeted by miR‐424 which further targeted by PMS2L2. This process might also be regulated by activating PKA/CREB and PI3K–AKT–GSK3β pathways.AbstractAimTo explore the protective effect of chemokine ligand 16 (CXCL16) against cell damage induced by oxygen‐glucose deprivation (OGD) in human microvascular endothelial cells‐1 (HMEC‐1) and its possible mechanism.MethodsCell Counting Kit‐8 (CCK‐8) assay...
Wed Apr 03, 2019 20:06
AbstractClear cell renal cell carcinoma (ccRCC) is a common urinary neoplasm, looking for useful candidates to establish scientific foundation for the therapy of ccRCC is urgent. We downloaded genomic profiles of GSE781, GSE6244, GSE53757, and GSE66271 from the Gene Expression Omnibus (GEO) database. GEO2R was used to analyze the derivative genes, while hub genes were screened by protein‐protein interactions and cytoscape. Further, overall survival, gene methylation, gene mutation, and gene...
Wed Apr 03, 2019 20:06
Inflammation induces an increase in pro‐inflammatory cytokine levels, which represses miR‐194‐5p expression. The dramatic decrease in miR‐194‐5p levels prevents it from playing an inhibitory role in CUL4A and CUL4B expression, resulting in their overexpression. The overexpressed CUL4A and CUL4B function as scaffolds to form CRL4 E3 ligases, which recognize and ubiquitinate the unknown substrates, eventually leading to the development of intervertebral disc degeneration (IDD).AbstractInflammation...
Wed Apr 03, 2019 20:05
Glucose transporter type 4 gene expression was increased significantly in the PSO group. Within‐group changes in fasting blood sugar (FBS) and quantitative insulin sensitivity check index (QUICKI) index were significant in the pomegranate seed oil (PSO) group. After adjusting the age, gender, and baseline values, FBS was significantly decreased.AbstractAbnormality in glucose transporter type 4 (GLUT‐4) function and insulin secretion are the main causes of type 2 diabetes mellitus (T2DM)....
Wed Apr 03, 2019 20:05
MicroRNA (miRNA) microarray profiling of differentiating rat primary skeletal myoblasts revealed that interleukin (IL)‐8 increased expression of four miRNA species, which were not yet described in skeletal muscle. Predicted targets for these miRNAs, included genes associated with skeletal muscle hypertrophy. We found that IL‐8, similarly to IGF‐I, can be considered as an anticatabolic factor for skeletal muscle, and the proposed mechanisms of IL‐8 action include: (a) stimulation of myocilin...
Wed Apr 03, 2019 20:05
Melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression.AbstractChildhood cancer management has improved considerably, with the overall objective of preventing early‐life cancers completely. However, cancer remains a major cause of death in children, with the survivors developing anticancer treatment‐specific health problems. Therefore, the anticancer treatment needs further improvement. Melatonin...
Wed Apr 03, 2019 20:03
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