LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunityLKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity, Published online: 25 March 2019; doi:10.1038/s41422-019-0157-4LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity
Mon Mar 25, 2019 02:00
Cells, Vol. 8, Pages 283: Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy Cells doi: 10.3390/cells8030283 Authors: Nabil Eid Yuko Ito Akio Horibe Yoshinori Otsuki Yoichi Kondo This study was conducted to elucidate the involvement of the PINK1-Parkin pathway in ethanol-induced mitophagy among Sertoli cells (SCs). In the research, adult rats were given intraperitoneal injections of ethanol (5 gm/kg)...
Mon Mar 25, 2019 02:00
Cells, Vol. 8, Pages 282: Characteristics and Potentiality of Human Adipose-Derived Stem Cells (hASCs) Obtained from Enzymatic Digestion of Fat Graft Cells doi: 10.3390/cells8030282 Authors: Pietro Gentile Maria Serena Piccinno Claudio Calabrese Human adipose-derived stem cells localize in the stromal-vascular portion, and can be ex vivo isolated using a combination of washing steps and enzymatic digestion. For this study, we undertook a histological evaluation of traditional fat...
Mon Mar 25, 2019 02:00
Cells, Vol. 8, Pages 281: Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer Cells doi: 10.3390/cells8030281 Authors: Sundy N. Y. Yang Sarah C. Atkinson Johanna E. Fraser Chunxiao Wang Belinda Maher Noelia Roman Jade K. Forwood Kylie M. Wagstaff Natalie A. Borg David A. Jans Dengue virus (DENV) threatens almost 70% of the world’s population, with no effective vaccine or therapeutic currently available. A key...
Sun Mar 24, 2019 02:00
Cells, Vol. 8, Pages 280: 2,4 Dinitrophenol as Medicine Cells doi: 10.3390/cells8030280 Authors: John G. Geisler In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest that warfarin, a rat poison, could be repositioned into a breakthrough drug in humans to protect against strokes as a...
Sat Mar 23, 2019 02:00
Cells, Vol. 8, Pages 279: FM19G11-Loaded Gold Nanoparticles Enhance the Proliferation and Self-Renewal of Ependymal Stem Progenitor Cells Derived from ALS Mice Cells doi: 10.3390/cells8030279 Authors: Stefania Marcuzzo Davide Isaia Silvia Bonanno Claudia Malacarne Paola Cavalcante Antonella Zacheo Valentino Laquintana Nunzio Denora Barbara Sanavio Elisa Salvati Patrizia Andreozzi Francesco Stellacci Silke Krol Maravillas Mellado-López Renato Mantegazza...
Sat Mar 23, 2019 02:00
Abstract The crosstalk between prokaryotic bacteria and eukaryotic gut epithelial cells has opened a new field for research. Quorum sensing system (QS) molecules employed by gut microbiota may play an essential role in host–microbial symbioses of the gut. Recent studies on the gut microbiome will unveil evolved mechanisms of the host to affect bacterial QS and shape bacterial composition. Bacterial autoinducers (AIs) could talk to the host's gut by eliciting proinflammatory effects...
Mon Mar 25, 2019 02:00
Abstract The use of opioid analgesics is severely limited due to the development of intractable constipation, mediated through activation of mu opioid receptors (MOR) expressed by enteric neurons. The related delta opioid receptor (DOR) is an emerging therapeutic target for chronic pain, depression and anxiety. Whether DOR agonists also promote sustained inhibition of colonic transit is unknown. This study examined acute and chronic tolerance to SNC80 and ARM390, which were full...
Sat Mar 23, 2019 02:00
Abstract Sumoylation is a reversible post-translational modification essential to the modulation of neuronal function, including neurotransmitter release and synaptic plasticity. A tightly regulated equilibrium between the sumoylation and desumoylation processes is critical to the brain function and its disruption has been associated with several neurological disorders. This sumoylation/desumoylation balance is governed by the activity of the sole SUMO-conjugating enzyme Ubc9 and...
Sat Mar 23, 2019 02:00
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